Food and water intake, body temperature and metabolic consequences of interleukin-1β microinjection into the cingulate cortex of the rat

Csetényi, Bettina; Hormay, Edina; Szabó, István; Takács, Gábor; Nagy, Bernadett; László, Kristóf; Karádi, Zoltán

doi:10.1016/j.bbr.2017.05.041

Cited by 4 publications

(2 citation statements)

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“…Paracetamol partially prevents the febrile response of the body induced by endogenous pyrogens, such as IL1β, including the administration of these pyrogens in brain tissues. Csetényi B. et al, 2017, proposed that prostaglandin-mediated mechanisms have an important role in the mechanism of action of IL1β in the cingulate cortex since paracetamol pre-treatment partially prevented an increase in the body temperature of Wistar rats [59].…”

Section: Anti-hyperthermic or Antipyretic Effects Of Paracetamolmentioning

confidence: 99%

Paracetamol-Induced Hypothermia in Rodents: A Review on Pharmacodynamics

et al. 2022

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Paracetamol can induce hypothermia in humans and rodents. The study’s aim is to review the mechanisms of paracetamol-induced hypothermia in rodents or the results issued from in vitro studies on the same species’ tissues (in doses that do not produce hepatic impairment) using the latest developments published in scientific journals over the last 15 years. Available human studies are also analysed. An extensive search in PubMed databases exploring the hypothermic response to paracetamol was conducted. 4669 articles about paracetamol’s effects on body temperature in mice or rats were found. After applying additional filters, 20 articles were selected for review, with 9 of them presented in tabular forms. The analysis of these articles found that the hypothermic effect of paracetamol is due to the inhibition of a cyclooxygenase-1 variant, is potentiated by endothelin receptor antagonists, and can be mediated through GABAA receptors and possibly through transient receptor potential cation channel subfamily A member 1 via N-acetyl-p-benzoquinone imine in the central nervous system. Human studies confirm the in vivo and in vitro experiments in rodents regarding the presence of a hypothermic effect after high, non-toxic doses of paracetamol. Further research is required to understand the mechanisms behind paracetamol’s hypothermic effect in humans.

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Section: Anti-hyperthermic or Antipyretic Effects Of Paracetamolmentioning

confidence: 99%

Paracetamol-Induced Hypothermia in Rodents: A Review on Pharmacodynamics

et al. 2022

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“…In microelectrophysiological experiments of our laboratory, the functional presence of IL-1b responsive neural cells has been elucidated in this cortical area. Based on all the above, the goal of the highlighted study [2] was to reveal whether cytokine mechanisms of the cingulate cortex are important in the central regulation of homeostasis. To do so, changes in food and water intake, body temperature, and other metabolic functions, i.e.…”

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confidence: 99%