Food and probiotic strains from the Saccharomyces cerevisiae species as a possible origin of human systemic infections

Llanos, Rosa de; Querol, Amparo; Pemán, Javier; Gobernado, M; Fernández-Espinar, M. Teresa

doi:10.1016/j.ijfoodmicro.2006.04.023

Cited by 65 publications

(56 citation statements)

References 19 publications

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“…A growing number of S. cerevisiae infections in humans have recently been reported (14). As a result, S. cerevisiae is also regarded as an emerging opportunistic pathogen that can cause clinically relevant infections in different patient types and body sites (15)(16)(17). One clinical strain (YJM145), derived from a yeast isolated from an AIDS patient with S. cerevisiae pneumonia (18), has been studied extensively as a model for fungal infections (19)(20)(21)(22)(23)(24).…”

mentioning

confidence: 99%

Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789

McCusker

Hyman

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

241

290

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We sequenced the genome of Saccharomyces cerevisiae strain YJM789, which was derived from a yeast isolated from the lung of an AIDS patient with pneumonia. The strain is used for studies of fungal infections and quantitative genetics because of its extensive phenotypic differences to the laboratory reference strain, including growth at high temperature and deadly virulence in mouse models. Here we show that the Ϸ12-Mb genome of YJM789 contains Ϸ60,000 SNPs and Ϸ6,000 indels with respect to the reference S288c genome, leading to protein polymorphisms with a few known cases of phenotypic changes. Several ORFs are found to be unique to YJM789, some of which might have been acquired through horizontal transfer. Localized regions of high polymorphism density are scattered over the genome, in some cases spanning multiple ORFs and in others concentrated within single genes. The sequence of YJM789 contains clues to pathogenicity and spurs the development of more powerful approaches to dissecting the genetic basis of complex hereditary traits.comparative genomics ͉ genome architecture ͉ introgression ͉ lateral gene transfer T here is extensive genetic and phenotypic diversity within species. Determining which of the vast amounts of sequence differences that are found among individuals of a species contribute to heritable traits will allow diseases to be tackled at the molecular level and aid in the development of novel therapies. Saccharomyces cerevisiae, commonly known as baker's or brewer's yeast, plays a central role in food production and is one of the most studied genetic model species. It is not only widely used in biotechnology but also is a powerful model system that has been applied to identify multigenetic factors of hereditary traits (1-7). The genome sequence of one laboratory strain, a derivative of S288c, was the first genome of a free-living eukaryotic organism to be sequenced (8). Over the last 10 years, this genome has served as the reference for the S. cerevisiae species and has catalyzed the development of whole-genome approaches to biology (9, 10). Despite frequent laboratory use of alternative strains, sequence information for S. cerevisiae beyond the domesticated strain S288c has been fragmentary. S288c, which originated from a strain isolated from a rotten fig, was chosen for sequencing because it possesses properties that make it easy to work with, such as minimal colony morphology switching, consistent growth rates in glucose media, and no flocculence (11). At several loci, S288c contains polymorphisms not found in natural isolates, which could be hallmarks of domestication (12,13). A growing number of S. cerevisiae infections in humans have recently been reported (14). As a result, S. cerevisiae is also regarded as an emerging opportunistic pathogen that can cause clinically relevant infections in different patient types and body sites (15)(16)(17). One clinical strain (YJM145), derived from a yeast isolated from an AIDS patient with S. cerevisiae pneumonia (18), has been studied extensively as ...

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mentioning

confidence: 99%

Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789

McCusker

Hyman

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

241

290

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“…Saccharomyces cerevisiae can cause invasive disease, particularly in transplant and cancer patients (Clemons et al, 2010). It is ingested frequently in foods and beverages (de Llanos et al, 2006), and it is not clear whether it is a persistent commensal in the digestive tract or is only present transiently after ingestion of food (Enache-Angoulvant and Hennequin, 2005). There are reports of serious infection of immunocompromised patients with S. boulardii, a subtype of S. cerevisiae used as a probiotic (Venugopalan et al, 2010).…”

Section: People With Pathological or Iatrogenic Immunosuppressionmentioning

confidence: 99%

The Occurrence and Prevention of Foodborne Disease in Vulnerable People

Lund

O’Brien

2011

Foodborne Pathogens and Disease

169

101

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In developed countries, such as the United Kingdom and the United States, between 15% and 20% of the population show greater susceptibility than the general population to foodborne disease. This proportion includes people with primary immunodeficiency, patients treated with radiation or with immunosuppressive drugs for cancer and diseases of the immune system, those with acquired immune-deficiency syndrome and diabetics, people suffering from liver or kidney disease or with excessive iron in the blood, pregnant women, infants, and the elderly. Malnutrition and use of antacids, particularly proton-pump inhibitors, also increase susceptibility. We review the occurrence of infection by foodborne pathogens in these groups of people and measures to prevent infection. The nature and use of low microbial diets to reduce the risk of foodborne disease in immunocompromised patients are very variable. Diets for vulnerable people in care should exclude higherrisk foods, and vulnerable people in the community should receive clear advice about food safety, in particular avoidance of higher-risk foods and substitution of safer, nutritious foods.

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“…boulardii is administrated to patients in a lyophilized form and the treatment is well tolerated. However, some rare cases of S. boulardii fungemias have been reported in patients with an indwelling central venous catheter (de Llanos et al, 2006;Hennequin et al, 2000;Lherm et al, 2002). The origin of the fungemia is thought to be either a digestive tract translocation or a contamination of the central venous line by the colonized hands of health workers (Hennequin et al, 2000).…”

Section: Safety Of Administrationmentioning

confidence: 99%

Saccharomyces boulardiieffects on gastrointestinal diseases

Zanello

Meurens²,

Berri³

et al. 2009

Current Issues in Molecular Biology

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Health benefits attributed to probiotics have been described for decades. They include the treatment and the prevention of gastrointestinal diseases, vaginal and urinary infections and allergies. Saccharomyces boulardii, a species of yeast widely distributed, has been described as a biotherapeutic agent since several clinical trials displayed its beneficial effects in the prevention and the treatment of intestinal infections and in the maintenance of inflammatory bowel disease. All these diseases are characterized by acute diarrhoea. Administration of the yeast in combination or not with an antibiotherapy has shown to decrease significantly the duration and the frequency of diarrhoea. Experimental studies elucidated partially the molecular mechanisms triggered to improve the host health. The discovery of its anti-inflammatory and immuno-modulatory activities in correlation with the advances in the understanding of mucosal immunology opens a new field of perspectives in S. boulardii therapeutic applications.

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Food and probiotic strains from the Saccharomyces cerevisiae species as a possible origin of human systemic infections

Cited by 65 publications

References 19 publications

Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789

Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789

The Occurrence and Prevention of Foodborne Disease in Vulnerable People

Saccharomyces boulardiieffects on gastrointestinal diseases

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