Food and nutritional insecurity is associated with depressive symptoms mediated by <i>NR3C1</i> gene promoter 1F methylation

Borçoi, Aline Ribeiro; Mendes, Suzanny Oliveira; Moreno, Ivana Alece Arantes; Santos, Joaquim Gasparini dos; Freitas, Flávia Vitorino; Pinheiro, Júlia Assis; Oliveira, Mayara Mota de; Barbosa, Wagner Miranda; Arpini, Juliana Krüger; Archanjo, Anderson Barros; Hollais, A.W.; Couto, Cinthia Vidal Monteiro da Silva; David, Camila Vieira Chagas; Quaioto, Bárbara Risse; Sorroche, Bruna Pereira; Louro, Iúri Drumond; Arantes, Lídia Maria Rebolho Batista; Silva, Adriana Madeira Álvares-da

doi:10.1080/10253890.2021.1923692

Cited by 11 publications

(9 citation statements)

References 45 publications

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“…A prevalence of individuals with symptoms of depression assessed in the population studied by the BDI-II inventory, considering a score ≥ 18, was 19.9%. Detailed analysis of obtained scores was 48.8% of individuals with these symptoms, with a cutoff of >10, considered above the population average normally found and frequently used in general population studies of non-psychiatric population 57 .…”

Section: Discussionmentioning

confidence: 99%

Psychotropic drug use and suggestive depression symptoms associated with NR3C1 DNA methylation

Pinheiro

Borçoi

Freitas

et al. 2023

jhgd

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Introduction: Psychiatric disorders have become a global problem that leads millions of people to use psychotropic medications, especially benzodiazepines. The effects of these substances are widely known regarding tolerance and chemical dependence, however, from epigenetics perspective, there are still little known. Objective: To evaluate the association between psychotropic drug use, NR3C1 gene methylation and its relation with symptoms suggestive of depression in adult individuals assisted in the public health system. Methods: 385 adult volunteers (20-59 years) users of the Brazilian Unified Health System were recruited to evaluate socioeconomic, health, lifestyle conditions in a cross sectional study. BDI-II evaluated symptoms suggestive of depression and pyrosequencing evaluated NR3C1 DNA methylation. Bivariate and multivariate Poisson regression model with robust variance (p < 0.05) evaluated the association between psychotropic drug use and NR3C1 gene methylation. Results: Specific depressive symptoms such as irritability, insomnia and fatigability were associated with psychotropic drug use. Symptoms of past failure, indecision and loss of appetite were associated with hypermethylation patterns in CpGs 40 to 47 of NR3C1 gene. Moreover, psychotropic drug use is associated with 50% reduction in NR3C1 gene methylation, through model adjusted with socioeconomic, health and lifestyle confounding variables. Conclusions: Psychotropic drug use and depressive symptoms was associated with changes in NR3C1 DNA methylation. In this context, epigenetic modification resulting from psychotropic drug use and depressive symptoms could be considered, mainly in population studies with epigenetic evaluation, where these factors may be influencing the findings of future studies.

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Section: Discussionmentioning

confidence: 99%

Psychotropic drug use and suggestive depression symptoms associated with NR3C1 DNA methylation

Pinheiro

Borçoi

Freitas

et al. 2023

jhgd

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“…Symptoms include anxiety, sadness, hopelessness, and emptiness, feelings of guilt or loss and worthlessness, irritability or frustration, loss of interest or pleasure in most routine activities, sleep disturbances, reduced or increased appetite, low energy, difficulty thinking and concentrating, impaired cognition, physical pity, and physical pity. Genetic and environmental risk factors influence depression ( Li et al, 2021 , Sales et al, 2021 , Borçoi et al, 2021 ). Epidemiologic studies show that genetic factors increase the risk of depression.…”

Section: Epigenetics and Dna Methylationmentioning

confidence: 99%

“…This could explain the heritability of depression ( Juruena et al, 2021 ). Exposure to stress results in the modification of DNA methylation in several genes associated with depression, including the glucocorticoid receptor (NR3C1 or GR), mineralocorticoid receptor (NR3C2 or MR), corticotrophin-releasing hormone receptor 1 (CRHR1), serotonin transporter (SLC6A4 or 5-HTT), brain-derived neurotrophic factor (BDNF), and FK506-binding protein 5 (FKBP5) ( Borçoi et al, 2021 , Drzymalla et al, 2021 , Ding and Dai, 2019 ). Different studies have reported the significant relationship between alteration in DNA methylation of FKBP5 with depressive symptoms ( Guo et al, 2021 , Han et al, 2017 , Höhne et al, 2015 ).…”

Section: Epigenetics and Dna Methylationmentioning

confidence: 99%

“…A review study showed a significant association between DNA methylation and depression risk. Hypermethylation of BDNF, CRMP2, NR3C1, and SLC6A4 is associated with Depression and MDD ( Xiang et al, 2021 , Li et al, 2021 , Borçoi et al, 2021 , Li et al, 2019 , Schiele et al, 2021 , Sanwald et al, 2021 , de Assis Pinheiro et al, 2021 ). Several studies have investigated DNA methylation of some critical genes modulating depressive symptoms, including PTPRN2 (correlated with mood state disturbances), HES5 (associated with MDD and suicide), GATA2 (related to depressive behavior in rats), DGKA (differed significantly between MDDs and controls), NIPA2 (increased risk of MDD), PRDM7 (important in aging and Alzheimer), KCNIP1 (regulate neuronal membrane excitability), GRIK2 (related to mood disorders and depressive symptoms) ( Wang et al, 2021 ).…”

Section: Epigenetics and Dna Methylationmentioning

confidence: 99%

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The role of DNA methylation in progression of neurological disorders and neurodegenerative diseases as well as the prospect of using DNA methylation inhibitors as therapeutic agents for such disorders

Rasmi

Shokati

Hassan

et al. 2023

IBRO Neuroscience Reports

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“… 6 The nutritional insecurity and lifestyle risk factors related to NR3C1 DNA methylation can act as a mediator of depressive symptoms, especially in cancer patients. 7 , 8 Epigenetic changes in glucocorticoid signaling, associated with genetic predisposition or environmental stressors, may also contribute to the pathophysiology of depression in cancer patients. 9 , 10 …”

Section: Introductionmentioning

confidence: 99%

Glucocorticoid Receptor Gene (NR3C1) Expression in the Pathogenesis of Depression in Cancer

Shim¹,

Yi²,

Ha³

et al. 2022

ALPHA PSYCHIATRY

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Background: This study aimed to compare the NR3C1 expression among cancer patients with major depressive disorder (cancer depression), cancer patients without major depressive disorder (cancer non-depression), and major depressive disorder patients without cancer (general depression), as a preliminary investigation of epigenetic changes in the glucocorticoid receptor gene. Methods: From May 2019 to November 2019, patients were recruited from the Department of Psychiatry, Cancer Center in Busan, Korea. For gene expression studies, primers were designed using the Primer3 web tool ( http://frodo.wi.mit.edu/primer3 ), and amplification reactions were performed. Results: Expression levels of NR3C1 were lower in cancer depression and general depression than in cancer non-depression group. Given that we observed downregulation of the NR3C1 gene expression in depressive patients regardless of cancer status, it appears that methylation changes in NR3C1 may contribute to the pathophysiology of depression. Conclusion: The results of this study imply that the expression of NR3C1 may be decreased in major depressive disorder.

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Food and nutritional insecurity is associated with depressive symptoms mediated by NR3C1 gene promoter 1F methylation

Cited by 11 publications

References 45 publications

Psychotropic drug use and suggestive depression symptoms associated with NR3C1 DNA methylation

Psychotropic drug use and suggestive depression symptoms associated with NR3C1 DNA methylation

The role of DNA methylation in progression of neurological disorders and neurodegenerative diseases as well as the prospect of using DNA methylation inhibitors as therapeutic agents for such disorders

Glucocorticoid Receptor Gene (NR3C1) Expression in the Pathogenesis of Depression in Cancer

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