Food and Nutrition in the Pathogenesis of Liver Damage

Mega, Andrea; Marzi, Luca; Kob, Michael; Piccin, Andrea; Floreani, Annarosa

doi:10.3390/nu13041326

Cited by 25 publications

(11 citation statements)

References 85 publications

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“…Food and lifestyle play an important role in keeping liver function from age-related deterioration. The hepatoprotective action of fruits, plants and other types of food have been reported previously (Mega et al, 2021).…”

Section: Introductionmentioning

confidence: 85%

Consumption of fish balls “tsumire” may help prevent liver function deterioration in aged rats

2022

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Background: Possible health benefits of fish balls tsumire consumption on human health have been deduced based on the results of our earlier study investigating tsumire consumption by young (6-weeks-old) Sprague-Dawley rats. Aim: The objectives of this study were to evaluate the effect of tsumire intake on aged rats by feeding them a diet containing 5% dried tsumire. Methods: Biomarker levels and organ weight of 80-weeks-old Sprague-Dawley rats that were fed with tsumire were examined for potential health benefits. Results: Following 84 days of administering tsumire-containing diet, we found a decrease in some liver function parameters, such as the levels of AST, ALT, ALP and LAP, in the tsumire-fed rats compared to control rats provided with normal diet. In particular, significantly reduced LDH levels were observed in the experimental group. Conclusions: The results can be extrapolated to possible beneficial effects of consumption of tsumire on human health.

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Section: Introductionmentioning

confidence: 85%

Consumption of fish balls “tsumire” may help prevent liver function deterioration in aged rats

2022

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“…The human body is exposed to a lifetime variety of xenobiotics that need to be properly recognized, metabolized, and excreted to preserve and maintain health. Ubiquitous sources of xenobiotics include natural foods and drink products that are routinely digested and detoxified, as well as byproducts of their cellular metabolism that can build up over time and become harmful [31]. The development of synthetic chemistry, agrochemical, and pharmaceutical industries exponentially increased the amount of foreign chemical substances that must be recognized and neutralized [1].…”

Section: Discussionmentioning

confidence: 99%

Guided Metabolic Detoxification Program Supports Phase II Detoxification Enzymes and Antioxidant Balance in Healthy Participants

Panda,

Komarnytsky,

Fleming

et al. 2023

Nutrients

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Adequate antioxidant supply is essential for maintaining metabolic homeostasis and reducing oxidative stress during detoxification. The emerging evidence suggests that certain classes of phytonutrients can help support the detoxification process by stimulating the liver to produce detoxification enzymes or acting as antioxidants that neutralize the harmful effects of free radicals. This study was designed to examine the effects of a guided 28-day metabolic detoxification program in healthy adults. The participants were randomly assigned to consume a whole food, multi-ingredient supplement (n = 14, education and intervention) or control (n = 18, education and healthy meal) daily for the duration of the trial. The whole food supplement contained 37 g/serving of a proprietary, multicomponent nutritional blend in the form of a rehydratable shake. Program readiness was ensured at baseline using a validated self-perceived wellness score and a blood metabolic panel, indicating stable emotional and physical well-being in both groups. No significant changes or adverse effects were found on physical or emotional health, cellular glutathione (GSH) and the GSH:GSSG ratio, porphyrin, and hepatic detoxification biomarkers in urine. The intervention was positively associated with a 23% increase in superoxide dismutase (p = 0.06) and a 13% increase in glutathione S-transferase (p = 0.003) activities in the blood. This resulted in a 40% increase in the total cellular antioxidant capacity (p = 0.001) and a 13% decrease in reactive oxygen species (p = 0.002) in isolated PBMCs from participants in the detoxification group. Our findings indicate that consuming a whole food nutritional intervention as a part of the guided detoxification program supported phase II detoxification, in part, by promoting enhanced free radical scavenging and maintaining redox homeostasis under the body’s natural glutathione recycling capacity.

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“…In the absence of dietary fibers, the gut microbiota cannot produce sufficient SCFAs, which may lead to a dysregulated inflammatory response and liver disease[ 99 , 100 ]. Most liver metabolism occurs through the catalysis of cytochrome P-450 (CYP-450), and it is known that many dietary biproducts can influence the activity of CYP-450[ 101 ]. Dietary retinoids, for example, are metabolized by hepatic cells, including hepatic stellate cells.…”

Section: Diet and Xenobiotics In Liver Diseasementioning

confidence: 99%

Microbiome-liver crosstalk: A multihit therapeutic target for liver disease

Kirundi¹,

Moghadamrad²,

Urbaniak³

2023

World J Gastroenterol

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Liver disease has become a leading cause of death, particularly in the West, where it is attributed to more than two million deaths annually. The correlation between gut microbiota and liver disease is still not fully understood. However, it is well known that gut dysbiosis accompanied by a leaky gut causes an increase in lipopolysaccharides in circulation, which in turn evoke massive hepatic inflammation promoting liver cirrhosis. Microbial dysbiosis also leads to poor bile acid metabolism and low short-chain fatty acids, all of which exacerbate the inflammatory response of liver cells. Gut microbial homeostasis is maintained through intricate processes that ensure that commensal microbes adapt to the low oxygen potential of the gut and that they rapidly occupy all the intestinal niches, thus outcompeting any potential pathogens for available nutrients. The crosstalk between the gut microbiota and its metabolites also guarantee an intact gut barrier. These processes that protect against destabilization of gut microbes by potential entry of pathogenic bacteria are collectively called colonization resistance and are equally essential for liver health. In this review, we shall investigate how the mechanisms of colonization resistance influence the liver in health and disease and the microbial-liver crosstalk potential as therapeutic target areas.

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Food and Nutrition in the Pathogenesis of Liver Damage

Cited by 25 publications

References 85 publications

Consumption of fish balls “tsumire” may help prevent liver function deterioration in aged rats

Consumption of fish balls “tsumire” may help prevent liver function deterioration in aged rats

Guided Metabolic Detoxification Program Supports Phase II Detoxification Enzymes and Antioxidant Balance in Healthy Participants

Microbiome-liver crosstalk: A multihit therapeutic target for liver disease

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