Food and Age: It Takes Two to Degenerate

Nicola, Raneen; Okun, Eitan

doi:10.3389/fnagi.2020.00182

Cited by 1 publication

(1 citation statement)

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“…Over the past few decades, human life expectancy has increased largely due to developments in pharmaceutical and healthcare technologies (Nicola & Okun, 2020). However, the increasing elderly population need for more effective prevention and management of infections and chronic diseases (Campisi et al., 2019; Olshansky, 2018).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of orally administered shark compound peptides from Chiloscyllium plagiosum against acute inflammation

et al. 2021

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The anti-inflammatory effects of shark compound peptides (SCP) from Chiloscyllium plagiosum were investigated. Results showed that SCP enhanced the viability of RAW 264.7 macrophages in vitro in a dose-dependent manner. Orally administered SCP exhibited potent anti-inflammatory activity in lipopolysaccharide (LPS)-challenged mice by suppressing serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), as well as nitric oxide (NO). Moreover, SCP significantly inhibited the inflammatory rise of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and creatinine (CRE), while blocking the decline of cholinesterase (CHE), with an efficacy close to aspirin. This research showed that orally administered SCP from C. plagiosum notably downregulated uncontrolled inflammatory responses, and conferred substantial protection from endotoxin-induced acute hepatic damage and renal functional impairment. Therefore, oral supplementation of SCP can be used as a preventive approach to reduce the risk of inflammatory-related diseases.

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Section: Introductionmentioning

confidence: 99%