Food Allergy Is Associated With Potentially Fatal Childhood Asthma

Vogel, N.M.; Katz, Hary T.; López, Rocío; Lang, David M.

doi:10.1080/02770900802444195

Cited by 51 publications

(36 citation statements)

References 15 publications

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“…La gravedad de la reacción alérgica a alimentos es multifactorial y variable, pero la presencia de DA puede condicionar una absorción de alergenos más rápida y ser otro factor que favorece una mayor severidad 34,35 . Si la DA persiste a pesar de manejo ópti-mo y tratamientos tópicos, o si existe historia evidente de reacción inmediata tras la ingesta de un alimento específico, los expertos sugieren realizar pruebas de AA para leche, huevo, maní, trigo y soya en niños menores de 5 años con DA moderada a severa.…”

Section: Estudios De Laboratoriounclassified

Relación entre dermatitis atópica y alergia alimentaria

2013

Rev. chil. pediatr.

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Section: Estudios De Laboratoriounclassified

Relación entre dermatitis atópica y alergia alimentaria

2013

Rev. chil. pediatr.

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“…Many studies have confirmed that asthma at risk of severe exacerbations or difficult to control asthma is mainly associated with allergic asthma in children [17,18]. Severe acute asthma requiring intensive care was more frequently found in cases of food allergy [19,20]. ROBERTS et al [19] compared 19 asthmatic children ventilated for severe exacerbation with 38 mild asthmatic children and showed that the two independent risk factors were the severity of asthma (OR 5.89, 95% CI 1.06-32.61) and food allergy (OR 9.85, 95% CI 1.04-93.27).…”

Section: Asthma With Severe Exacerbations and Multiple Allergiesmentioning

confidence: 99%

Two novel, severe asthma phenotypes identified during childhood using a clustering approach

Just

Gouvis-Echraghi²,

Rouve³

et al. 2012

Eur Respir J

152

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Unsupervised cluster analysis has already been used to identify severe phenotypes of childhood asthma, but without taking into account inflammatory markers. The aim of this study was to define independent homogeneous phenotypic clusters of severe asthma in a cohort of asthmatic children.Cluster analysis was applied to 19 variables from 315 children enrolled in the Trousseau Asthma Program in Paris, France.Three independent clusters of asthma were identified. Cluster 1, asthma with severe exacerbations and multiple allergies: 103 children had more sensitisations to inhaled allergens and food allergens, more blood eosinophils and basophils, more uncontrolled asthma despite high doses of inhaled corticosteroid and more hospitalisations for exacerbation. Cluster 2, severe asthma with bronchial obstruction: 72 children were significantly older, had the highest body mass index, a lower forced expiratory volume in 1 s, more pronounced blood neutrophils and significantly higher levels of all classes of immunoglobulin (Ig), except IgE. Cluster 3, mild asthma: 140 children did not show statistically significant features.These results could lead to improved management of severe asthma in children by optimising treatment strategies, i.e. anti-allergic drugs, such as anti-IgE for children with the allergic phenotype, and anti-neutrophil drugs, such as macrolides for those with the obstructive phenotype.

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“…Так, группа финских исследователей установила, что у детей с IgE-опосредованной аллергией к БКМ значительно увеличе-на концентрация NO в выдыхаемом воздухе и повышена реактивность бронхов в школьном возрасте, что является факторами, предрасполагающими к развитию астмы [6]. Более того, пищевая аллергия утяжеляет течение астмы [8], а также служит фактором риска развития потенциаль-но угрожающих ее форм [9].…”

Section: Discussionunclassified