Food allergy in Sri Lanka – A comparative study

Silva, Rajiva de; Karunatilake, Chandima; Iddagoda, Janitha; Dasanayake, Dhanushka

doi:10.1016/j.waojou.2022.100723

Cited by 5 publications

(3 citation statements)

References 49 publications

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“…AGS is reported in many areas around the globe (Figure 2), 4,13,25,53–81 but firm estimates of prevalence and incidence are difficult. Challenges in describing the epidemiology stem from the fact that AGS (i) is not a reportable disease, (ii) does not have a dedicated diagnostic medical billing code (at least in the USA), (iii) has marked regional variability and (iv) the alpha‐gal sIgE test may also be costly for some patients, leading to underdiagnosis.…”

Section: Epidemiology Relationship To Ticks and Other Risk Factorsmentioning

confidence: 99%

Tick bites, IgE to galactose‐alpha‐1,3‐galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha‐gal syndrome

Wilson,

Erickson,

Levin

et al. 2024

Allergy

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The recent recognition of a syndrome of tick‐acquired mammalian meat allergy has transformed the previously held view that mammalian meat is an uncommon allergen. The syndrome, mediated by IgE antibodies against the oligosaccharide galactose‐alpha‐1,3‐galactose (alpha‐gal), can also involve reactions to visceral organs, dairy, gelatin and other products, including medications sourced from non‐primate mammals. Thus, fittingly, this allergic disorder is now called the alpha‐gal syndrome (AGS). The syndrome is strikingly regional, reflecting the important role of tick bites in sensitization, and is more common in demographic groups at risk of tick exposure. Reactions in AGS are delayed, often by 2–6 h after ingestion of mammalian meat. In addition to classic allergic symptomatology such as urticaria and anaphylaxis, AGS is increasingly recognized as a cause of isolated gastrointestinal morbidity and alpha‐gal sensitization has also been linked with cardiovascular disease. The unusual link with tick bites may be explained by the fact that allergic cells and mediators are mobilized to the site of tick bites and play a role in resistance against ticks and tick‐borne infections. IgE directed to alpha‐gal is likely an incidental consequence of what is otherwise an adaptive immune strategy for host defense against endo‐ and ectoparasites, including ticks.

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Section: Epidemiology Relationship To Ticks and Other Risk Factorsmentioning

confidence: 99%

Tick bites, IgE to galactose‐alpha‐1,3‐galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha‐gal syndrome

Wilson,

Erickson,

Levin

et al. 2024

Allergy

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“…Common manifestations of OAS occur within minutes of consuming the fruit and include itching or a burning sensation in the mouth, including the lips, tongue, and throat, which may be accompanied by swelling. In some cases, individuals may also experience vomiting, diarrhea, and, rarely, anaphylaxis (Boyce et al, 2010;de Silva et al, 2022;Soares et al, 2014;Wang et al, 2019). Mango-related immediate hypersensitivity reactions might take the form of either a local or systemic allergic reaction.…”

Section: Clinical Symptomsmentioning

confidence: 99%

A comprehensive review on mango allergy: Clinical relevance, causative allergens, cross‐reactivity, influence of processing techniques, and management strategies

Zhao,

Camus‐Ela,

Zhang

et al. 2024

Comp Rev Food Sci Food Safe

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Mangoes (Mangifera indica) are widely prized for their abundant nutritional content and variety of beneficial bioactive compounds and are popularly utilized in various foods, pharmaceuticals, and cosmetics industries. However, it is important to note that certain proteins present in mango can trigger various allergic reactions, ranging from mild oral allergy syndrome to severe life‐threatening anaphylaxis. The immunoglobulin E‐mediated hypersensitivity of mango is mainly associated with three major allergenic proteins: Man i 1 (class IV chitinase), Man i 2 (pathogenesis‐related‐10 protein; Bet v 1‐related protein), and Man i 4 (profilin). Food processing techniques can significantly affect the structure of mango allergens, reducing their potential to cause allergies. However, it is worth mentioning that complete elimination of mango allergen immunoreactivity has not been achieved. The protection of individuals sensitized to mango should be carefully managed through an avoidance diet, immediate medical care, and long‐term oral immunotherapy. This review covers various aspects related to mango allergy, including prevalence, pathogenesis, symptoms, and diagnosis. Furthermore, the characterization of mango allergens and their potential cross‐reactivity with other fruits, vegetables, plant pollen, and seeds were discussed. The review also highlights the effects of food processing on mango and emphasizes the available strategies for managing mango allergy.

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“…It can cause serious health problems even leading to fatal events. The incidence and severity of food allergies are increasing worldwide, particularly in children [2][3][4]. Food allergy has a significant negative impact on the quality of life of those affected and their families, causing emotional, social, and financial stress [5,6].…”

Section: Understanding Food Allergies: the Definition Of Food Allergy...mentioning

confidence: 99%

Food-labeling issues for severe food-allergic consumers

Dinardo

Fierro

Giudice

et al. 2023

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewFood label represent the primary and only source of information before consuming a food product. Deputy government agencies on five continents require allergenic ingredients to be declared when used in prepackaged foods to assist patients in identifying allergenic foods and to help them to choose wisely. Unfortunately, the mandatory allergen list and legislation regarding food labels and reference doses is not uniform and varies by country. This may add difficulties to food-allergic patients, especially those with severe food allergy. Recent findingsA new definition of food allergy severity (the DEFASE grid, developed by the World Allergy Organization), aims to assist clinicians in the identification of the at-risk patients. The FASTER ACT and Natasha's Laws has made important improvements such as the entry of sesame as a major allergen in the United States, and increased evidence of allergens on the food label within prepackaged for direct sale (PPDS) in the UK. The recent introduction of Vital 3.0 brought important new features such as an updated reference doses for many foods. SummaryCurrently, there are still considerable differences regarding food labels in different countries. Growing public and scientific attention to the problem promises to increase the food safety for allergens. Among the next improvements, we expect a reconsideration of the food reference doses, a harmonization of the food oral challenge process, and the promulgation of regulatory rules for the precautionary labeling.

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Food allergy in Sri Lanka – A comparative study

Cited by 5 publications

References 49 publications

Tick bites, IgE to galactose‐alpha‐1,3‐galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha‐gal syndrome

Tick bites, IgE to galactose‐alpha‐1,3‐galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha‐gal syndrome

A comprehensive review on mango allergy: Clinical relevance, causative allergens, cross‐reactivity, influence of processing techniques, and management strategies

Food-labeling issues for severe food-allergic consumers

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