Food Allergy in Children with Asthma: Prevalence and Correlation with Clinical Severity of Respiratory Disease

Calamelli, Elisabetta; Ricci, Giampaolo; Dell'Omo, Valeria; Bendandi, Barbara; Masi, Massimo

doi:10.2174/1874838400801010005

Cited by 7 publications

(18 citation statements)

References 37 publications

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“…Previous studies have shown that the incidences of FA in asthmatic children range from 4% to 44%. 4 34 36 37 38 39 A high incidence of FA in certain studies may result from methodological differences in diagnosis: FA was diagnosed only on the basis of results of the history or sIgE levels above a 95% positive predictive value, while in our study FA was diagnosed on the basis of DBPCFC results.…”

Section: Discussionmentioning

confidence: 60%

“…Previous studies have indicated that the incidence of sensitization to food allergens in asthmatic children varies between 29.3% and 77%. 37 38 39 The lower sensitization rate noted in this study may be due to older age, less frequent occurrence, or the presence of another phenotype of FA in Poland.…”

Section: Discussionmentioning

confidence: 68%

“…Children were most frequently sensitized to vegetables, wheat, hen's egg, and fruit, but rarely to cow's milk, hazelnuts, and peanuts. In contrast, Calamelli et al 38 reported that the most frequent food allergens were wheat and peanuts, while Patelis et al reported that they were fruit and hazelnuts. 20 …”

Section: Discussionmentioning

confidence: 92%

“…The food types which most frequently provided positive results in the DBPCFC were hen's egg and cow's milk, followed by peanuts, celery, and fish. According to Rance and Dutau 34 or Calamelli et al, 38 the most common food allergen was peanut, followed by hen's egg and cow's milk. 34 38 Thus, our findings do not significantly differ from those obtained by other European authors.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Clinical Impact of IgE-Mediated Food Allergy in School Children With Asthma: A Double-Blind Placebo-Controlled Food Challenge Study

Krogulska

Dynowski

Funkowicz

et al. 2015

Allergy Asthma Immunol Res

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PurposeRecent studies indirectly suggest a possible link between food allergy (FA) and asthma. Most of them have evaluated the occurrence of FA in asthmatic children, especially in the first year of life, using questionnaire-based studies or specific IgE (sIgE) assay. The aim of this study was to evaluate the prevalence and clinical impact of IgE-mediated FA in school children with asthma using a double-blind placebo-controlled food challenge (DBPCFC).MethodsThe study group consisted of school children with atopic asthma who were admitted to the Department of Pediatric Allergology, Gastroenterology and Nutrition, Medical University of Lodz, for the evaluation of food hypersensitivity. The diagnosis of FA was established using questionnaires, sIgE analysis, and the DBPCFC. Asthma severity and asthma control state were also assessed.ResultsA relationship between consumed food and complaints was reported in 180 children (49.7%). Seventy children (19.3%) were sensitized to food allergens. IgE-mediated FA was confirmed in 24 children (6.6%), while 11 children (3%) demonstrated respiratory symptoms. Food-induced asthma exacerbations were observed in 9 patients (2.5%). Statistically significant differences in the prevalence of atopic dermatitis (P<0.002), urticaria (P<0.03), digestive symptoms (P<0.03), rhinitis (P<0.02), sIgE level (P<0.001), positive family history of atopy (P<0.001) and FA in history (P<0.001) were found between asthmatic children with FA and those without. Children with food-induced asthma exacerbations demonstrated significantly greater severity, poorer controls, and worse morbidity compared to those without.ConclusionsAlthough food-induced respiratory reactions in children with asthma were rare, they were classified as severe and associated with worse morbidity, greater severity, and poorer control. As the most commonly observed symptoms were coughing and rhinitis, which can be easily misdiagnosed, a proper diagnosis is essential for improving the management of both clinical conditions.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Prevalence and Clinical Impact of IgE-Mediated Food Allergy in School Children With Asthma: A Double-Blind Placebo-Controlled Food Challenge Study

Krogulska

Dynowski

Funkowicz

et al. 2015

Allergy Asthma Immunol Res

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“…The secondary form occurs more frequently [1, 6–9, 11, 18, 40, 41]. Although the provocation tests with foods are not always performed routinely, they may be considered to be the definite confirmation of involvement of particular foods in the patient's complaints [1–13, 18, 20, 22, 25, 27, 28, 40, 42–51].…”

Section: Introductionmentioning

confidence: 99%

Late Type of Bronchial Response to Milk Ingestion Challenge: A Comparison of Open and Double-Blind Challenge

Pelikán¹

2012

Journal of Allergy

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Background. In some asthmatics the food allergy, for example, to milk, can participate in their bronchial complaints. The role of food allergy should be confirmed definitively by food ingestion challenge performed by an open challenge with natural foods (OFICH) or by a double-blind placebo-controlled food challenge (DBPCFC). Objectives. To investigate the diagnostic value of these techniques for confirmation of a suspected milk allergy in bronchial asthma patients. Methods. In 54 asthmatics with a positive history and/or positive skin tests for milk the 54 OFICH, and DBPCFC, were performed in combination with spirometry. Results. The 54 patients developed 39 positive late asthmatic responses (LAR) and 15 negative asthmatic responses to OFICH and 40 positive LARs and 14 negative responses to DBPCFC. The overall correlation between the OFICH and DBPCFC was statistically significant (P < 0.01). Conclusions. This study has confirmed the existence of LAR to milk ingestion performed by OFICH and DBPCFC in combination with spirometry. The results obtained by both the techniques did not differ significantly. The OFICH with natural food combined with monitoring of objective parameter(s), such as spirometry, seems to be a suitable method for detection of the food allergy in asthmatics. The DBPCFC can be performed as an additional check, if necessary.

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Food allergy in children with asthma and its correlation with level of asthma control

Cherian

Lakshminarasappa

Chandrasekaran

et al. 2022

Health Science Reports

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Background There is paucity of regional data regarding food allergy among children with asthma. Objectives To estimate the proportion of children with asthma who have food‐related respiratory symptoms and to correlate it with (a) skin prick test (SPT) results and (b) level of asthma control. Methodology This cross‐sectional study involved children with asthma, aged ≥6 years attending the childhood asthma clinic in a tertiary care hospital, in the southern part of India from July 2017 to July 2019. Basic demography and clinical details were recorded. In subjects with a history of food allergy, skin prick test (SPT) was done using AllergoSPT according to guidelines recommended by British Society of Allergy and Clinical Immunology (BSACI). Asthma control was assessed using asthma control test (ACT) and childhood ACT questionnaires. Results Of the total 305 children included, the most commonly reported allergen was banana (45%, n = 137). The predominant symptom reported was wheezing (54%). SPT was positive in 76 children (24.9%). Level of asthma control ( P value < .01), family history of atopy ( P value < .01), and age at introduction of complementary foods ( P value < .01) were significantly associated with food allergy. Conclusion Presumed food allergy is seen in one‐fourth of children with asthma and significantly affects symptom control in them.

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Food Allergy in Children with Asthma: Prevalence and Correlation with Clinical Severity of Respiratory Disease

Cited by 7 publications

References 37 publications

Prevalence and Clinical Impact of IgE-Mediated Food Allergy in School Children With Asthma: A Double-Blind Placebo-Controlled Food Challenge Study

Prevalence and Clinical Impact of IgE-Mediated Food Allergy in School Children With Asthma: A Double-Blind Placebo-Controlled Food Challenge Study

Late Type of Bronchial Response to Milk Ingestion Challenge: A Comparison of Open and Double-Blind Challenge

Food allergy in children with asthma and its correlation with level of asthma control

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