Food Allergies

Bowman, Christal C.

doi:10.1007/978-1-61779-812-2_5

Cited by 1 publication

(2 citation statements)

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“…As such, food allergy is considered a failure to generate oral tolerance, or a failure of oral tolerance mechanisms. In overall terms, tolerance can occur in any tissue, but antigens in the gut are under specialized pathways that lead to oral tolerance, which includes suppression of both cellular and humoral immune responses [18]. Tolerance to food antigens can be induced through the presence of various immune cells and tissues in the intestinal mucosal system.…”

Section: Antigen Tolerance and Antioxidant Response In The Intestinesmentioning

confidence: 99%

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Participation of reactive oxygen species in the pathogenesis of food allergies

Skalska,

Kleniewska,

Pawliczak

2023

pja

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There has been a significant increase in the incidence of allergic diseases for several decades. There is even a talk of "an epidemic of the 21 st century" in relation to, for example, food allergies (FAs). Modern lifestyle and environmental factors contribute to a further increase in disease incidence. The authors proved that the first three years of life are a very important period for the proper development of microflora and taking actions in the context of prevention/therapy; and antibiotic therapy and diet play a significant role in shaping a stable microbiota. An adverse immune reaction to food is referred to as a FA. Immune reactions to food allergens can generally be divided into: IgE-mediated, non-IgE-mediated and mixed. Reactive oxygen species (ROS) are involved in the pathogenesis of FAs. Oxidative stress induces inflammation in tissues; excessive amounts of ROS damage intestinal tissue, disrupt normal cell function, and in eosinophilic esophagitis (EoE) impair the Keap1/Nrf2 pathway.

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Section: Antigen Tolerance and Antioxidant Response In The Intestinesmentioning

confidence: 99%

“…Small amounts of antigen cross the intestinal barrier intact, and tolerance mechanisms allow it to do so harmlessly. However, excessive permeability can increase the antigen load and be harmful [18]. The human body is equipped with a number of antioxidant mechanisms to balance ROS.…”

Section: Antigen Tolerance and Antioxidant Response In The Intestinesmentioning

confidence: 99%