Plan: Ayurveda makes use of many Kvatha or hot infusions. In olden days the physician provided a handwritten recipe of the Kvatha in question and patients prepared these medicines at home. However, this tradition ended with the advent of commercial manufacture of Ayurvedic medicines in Kerala since 1902. Considering the growing popularity of Ayurveda, an attempt was made to compare the quality of seven brands of Maharasnadi Kvatha, a formulation that is widely recommended by physicians.Methodology: Seven brands of Maharasnadi Kvatha available in the local market were procured. Their pH, total dissolved solids, sodium benzoate content, HPTLC profiles and microbial load were measured. Additionally, the presence of alkaloids, tannins, phenols, and sterols was detected qualitatively. Total tannins, alkaloids, phenols and sterols were estimated.Outcome: The colour of the seven brands, their pH, total dissolved solids, sodium benzoate content, HPTLC profiles, microbial load and content of compound classes showed wide variation. HPTLC fingerprinting can serve as a useful technique to assess the quality of Ayurvedic medicines. The number of bands and their area percentages can serve as quality indices. Such methods can be used for improving the quality of Ayurvedic medicines.