Food Additives as Novel Influenza Vaccine Adjuvants

Feng, Huapeng; Yamashita, Makoto; Wu, Li; Lopes, Tiago José da Silva; Watanabe, Tokiko; Kawaoka, Yoshihiro

doi:10.3390/vaccines7040127

Cited by 2 publications

(3 citation statements)

References 46 publications

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“…IgG1 and IgG2a are stimulated during Th2-type and Th1-type immune responses, respectively [ 40 , 41 , 42 ]. Previous studies have shown that immunization of mice with Ebola VLPs strongly induces IgG2a antibodies but low levels of IgG1 antibodies [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…Virus-specific antibody titers in the mouse sera were determined by using a modified ELISA as previously described [ 31 , 40 , 41 , 42 ]. Briefly, 96-well ELISA plates (IWAKI) were coated with 5 µg/mL of purified GP mutant protein solution, which was produced as described in the Supplementary Information , overnight at 4 °C (50 µL/well).…”

Section: Methodsmentioning

confidence: 99%

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Identification of Novel Adjuvants for Ebola Virus-Like Particle Vaccine

et al. 2020

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Ebola virus disease is a severe disease, often fatal, with a mortality rate of up to 90%. Presently, effective treatment and safe prevention options for Ebola virus disease are not available. Therefore, there is an urgent need to develop control measures to prevent or limit future Ebola virus outbreaks. Ebola virus protein-based virus-like particle (VLP) and inactivated whole virion vaccines have demonstrated efficacy in animal models, and the addition of appropriate adjuvants may provide additional benefits to these vaccines, including enhanced immune responses. In this study, we screened 24 compounds from injectable excipients approved for human use in Japan and identified six compounds that significantly enhanced the humoral response to Ebola VLP vaccine in a murine model. Our novel adjuvant candidates for Ebola VLP vaccine have already been demonstrated to be safe when administered intramuscularly or subcutaneously, and therefore, they are closer to clinical trials than adjuvants whose safety profiles are unknown.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Identification of Novel Adjuvants for Ebola Virus-Like Particle Vaccine

et al. 2020

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“…Although Quil A and its derivative QS-21 have been assessed as influenza vaccine adjuvants in humans, there are no clear advantages in terms of immunity induced by vaccines with or without these adjuvants [ 74 , 75 ]. A recent screen of compounds from food additives identified saponin as a good adjuvant candidate since it enhanced the immune response elicited by the split influenza vaccine in mice [ 76 ].…”

Section: Progress In the Development Of Adjuvants For Influenza Vaccinesmentioning

confidence: 99%

Advances in Adjuvanted Influenza Vaccines

Shichinohe,

Watanabe

2023

Vaccines

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The numerous influenza infections that occur every year present a major public health problem. Influenza vaccines are important for the prevention of the disease; however, their effectiveness against infection can be suboptimal. Particularly in the elderly, immune induction can be insufficient, and the vaccine efficacy against infection is usually lower than that in young adults. Vaccine efficacy can be improved by the addition of adjuvants, and an influenza vaccine with an oil-in-water adjuvant MF59, FLUAD, has been recently licensed in the United States and other countries for persons aged 65 years and older. Although the adverse effects of adjuvanted vaccines have been a concern, many adverse effects of currently approved adjuvanted influenza vaccines are mild and acceptable, given the overriding benefits of the vaccine. Since sufficient immunity can be induced with a small amount of vaccine antigen in the presence of an adjuvant, adjuvanted vaccines promote dose sparing and the prompt preparation of vaccines for pandemic influenza. Adjuvants not only enhance the immune response to antigens but can also be effective against antigenically different viruses. In this narrative review, we provide an overview of influenza vaccines, both past and present, before presenting a discussion of adjuvanted influenza vaccines and their future.

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Food Additives as Novel Influenza Vaccine Adjuvants

Cited by 2 publications

References 46 publications

Identification of Novel Adjuvants for Ebola Virus-Like Particle Vaccine

Identification of Novel Adjuvants for Ebola Virus-Like Particle Vaccine

Advances in Adjuvanted Influenza Vaccines

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