Fonsecaea associated cerebral phaeohyphomycosis in a post-COVID-19 patient: A first case report

Laiq, Simin; Yaqoobi, Mubarak Al; Saadi, Maimuna Al; Rizvi, S.M.H.; Hajri, Zahra Al; Azri, Saleh Al; Ramadhani, Khalsa Al; Hinai, Qasim Al

doi:10.1016/j.clinpr.2021.100126

Cited by 6 publications

(7 citation statements)

References 13 publications

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“…Fungal brain abcesses may appear like a tumor mass [ 4 , 15 ]. The imaging studies are usually non-specific and cannot distinguish between fungal and bacterial brain abscesses.…”

Section: Discussionmentioning

confidence: 99%

“…Beside this, the pathophysiology of primary disease acquisition is not clear, possibilities includes seeding from fungal otitis media/sinusitis. Subclinical pulmonary infections leading to hematogenous spread is considered the main culprit by most physician [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…The most accurate and probably frequently used approach of diagnosis involves identifying pigmented fungi from brain tissue histopathology or culture. The most effective course of treatment involves surgical resection and prompt administration of a combination of antifungal medications [ [4] , [5] , [6] ]. Many dematiaceous fungal species have been linked to CP, with Cladophialophora bantiana and Rhinocladiella mackenziei accounting for roughly 50 % and 15 % of CP cases, respectively [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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A rare case of cerebral phaeohyphomycosis caused by Fonsecaea species in a renal transplant patient

Qureshi,

Absar,

Nasser

et al. 2024

Medical Mycology Case Reports

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“…Fungal brain abcesses may appear like a tumor mass [ 4 , 15 ]. The imaging studies are usually non-specific and cannot distinguish between fungal and bacterial brain abscesses.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A rare case of cerebral phaeohyphomycosis caused by Fonsecaea species in a renal transplant patient

Qureshi,

Absar,

Nasser

et al. 2024

Medical Mycology Case Reports

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“…The other major factors that reduced immune functions include malnutrition, tumors, and kidney transplantations. Under the background of the global COVID-19 pandemic, Simin Laiq was the first to report a case of Fonsecaea -associated cerebral PHM in a 73 years old Omani diabetic lady who presented headache and visual disturbance 6 weeks after recovery from COVID-19 pneumonia ( Laiq et al., 2022 ). Actually, treatment with steroids and exacerbation of diabetes during COVID-19 infection may lead patients to be immunocompromised and more susceptible to fungal infections.…”

Section: Discussionmentioning

confidence: 99%

Phaeohyphomycosis in China

Zheng

Mei

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundDue to more attentions paid to melanized fungi over the past few decades and under the background of the global coronavirus disease 2019 pandemic (COVID-19) the fact that the virus itself and the immunosuppressive agents such as glucocorticoids can further increase the risk of infections of deep mycoses, the number of patients with phaeohyphomycosis (PHM) has a substantial increase. Their spectrum is broad and the early diagnosis and treatments are extremely sticky. This study aims to more comprehensively understand the clinical features of phaeohyphomycosis in China over 35 years and to establish a more applicable systematical classification and severity grades of lesions to guide treatments and prognosis.MethodsWe reviewed 174 cases of proven phaeohyphomycosis reported in Chinese and English language literature from 1987 to 2021 and we also made the accurate classification definitions and detailed information about the epidemiology, species of clinical dematiaceous fungi, minimum inhibitory concentration values, clinical features, treatments, and prognosis.ResultsThe mortality of cerebral, disseminated and pulmonary phaeohyphomycosis are 55%, 36%, and 25%. Nearly 19% of patients had poor quality of life caused by the complications such as disability, disfigurements, and blindness. The overall misdiagnosis rate of phaeohyphomycosis was 74%. Moderate to severe rashes are accounting for 82% of subcutaneous phaeohyphomycosis. The areas of the head and face are mostly affected accounting for 16% of severe rashes. Nearly 30% of invasive infections of phaeohyphomycosis are triggered by recurrent lesions. Voriconazole, itraconazole, amphotericin B deoxycholate (AmB-DOC), and terbinafine were most commonly used but diagnosis and treatments of phaeohyphomycosis remain challenging in reality.ConclusionsOur classifications are likely to be more practical and easier to popularize, and there are still also plenty of characteristics in these non-specific lesions. There’re no significant variations in cure rates, or death rates between three grades of lesions. But patients with severe rashes have longer courses and lower effective rates.

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“…from Oman also reported a case of post-COVID-19 CH. [ 5 ] Such a case raises the question of whether post-COVID-19 CH is a Middle Eastern replica of post-COVID-19 mucormycosis, which has comparable agent, host, and environmental factors. Therefore, we emphasize more observation, reporting, and study of such cases.…”

mentioning

confidence: 99%