Abstract:Insufficient maternal folate concentrations appear to be a fetal risk factor for neural tube defects (NTD). Erythrocyte folate concentrations are widely accepted as an indicator of tissue folate storage. We retrospectively evaluated erythrocyte folate concentrations to examine if a recommended daily dosage of 5 mg folic acid is sufficient to balance the impact of antiepileptic drugs (AED) on folate metabolism in women with epilepsy. Data of 48 women (mean age 30.3 years) with idiopathic epilepsy with generaliz… Show more
“…The measurement that determines intra-erythrocythal level of folic acid may help with definition of optimal dose. Results suggest, that 5 mg/day folic acid as preconception supplementation in women with epilepsy is effective to balance the impact of AEDs on folate metabolism (Bauer et al, 2010). Folate profylaxis is recommended to all women taking antiepileptic drugs.…”
Section: Folic Acid Supplementation and Its Profitmentioning
“…The measurement that determines intra-erythrocythal level of folic acid may help with definition of optimal dose. Results suggest, that 5 mg/day folic acid as preconception supplementation in women with epilepsy is effective to balance the impact of AEDs on folate metabolism (Bauer et al, 2010). Folate profylaxis is recommended to all women taking antiepileptic drugs.…”
Section: Folic Acid Supplementation and Its Profitmentioning
Epilepsy is a common neurological condition with gender-related management implications. Epilepsy and antiepileptic drug treatment affect aspects of contraception, fertility and pregnancy which are discussed in the article.
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