Follow-up Study on Pulmonary Function and Lung Radiographic Changes in Rehabilitating Severe Acute Respiratory Syndrome Patients After Discharge

Xie, Lixin; Liu, You-ning; Xiao, Yueyong; Tian, Qing; Fan, Bin; Zhao, Hong; Chen, Weijun

doi:10.1378/chest.127.6.2119

Cited by 123 publications

(134 citation statements)

References 7 publications

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“…This suggests that the mechanism of lung injury and lung fibrotic changes caused by H1N1 might have a different pathophysiological process compared with other diseases of the lung. H1N1 patients with lung fibrotic changes seem to have the ability for self-rehabilitation, which is similar to SARS cases [33].…”

Section: Discussionmentioning

confidence: 63%

Serial evaluation of high-resolution CT findings in patients with pneumonia in novel swine-origin influenza A (H1N1) virus infection

Zhang²,

X³

et al. 2012

BJR

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Objectives: The purpose of our study was to review the changes in the serial highresolution CT (HRCT) findings from patients with novel swine-origin influenza A (H1N1) virus (S-OIV) infection. Methods: HRCT findings of 70 patients with presumed or laboratory-confirmed novel S-OIV infection were reviewed. The pattern (consolidation, ground glass, fibrosis and air trapping), distribution and extent of abnormality of the lesions on the HRCT were evaluated at different time points. To assess changes that occurred over time, the CT scans in 56 patients were examined in sequence. Results: The most common CT findings in patients with S-OIV infection are groundglass opacities with or without consolidation at the first week. The abnormalities peaked at the second week and resolved after that time, which resulted in substantial reduced residual disease at 4 weeks or later. The development of fibrosis was noted in the first week and peaked at the third week of illness (34.7%), then decreased slowly after that time. The mean time of air trapping being noted after the onset of symptoms was 55.5¡20.6 days. Comparing the findings of initial CT, most results (96.4%) of follow-up chest CT findings showed improvement (p,0.01). Conclusion:The abnormalities of ground-glass opacities and/or consolidation on initial CT scans tended to resolve to fibrosis, which then resolved completely or displayed substantially reduced residual disease. HRCT may show more changes in disease progression and play an important role in the evaluation of severe S-OIV.

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Section: Discussionmentioning

confidence: 63%

Serial evaluation of high-resolution CT findings in patients with pneumonia in novel swine-origin influenza A (H1N1) virus infection

Zhang²,

X³

et al. 2012

BJR

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“…Sheng et al 22 have shown that viral infection could increase the risk of pulmonary fibrosis. Xie et al 23 found that 45% of patients showed signs of pulmonary fibrosis within 1 month after being infected with SARS‐CoV. Hui 24 revealed that 36% and 30% of patients infected with SARS‐CoV developed pulmonary fibrosis 3 and 6 months after infection.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of hospitalized patients with SARS‐CoV‐2 infection: A single arm meta‐analysis

Sun

Qie

Liu

et al. 2020

Journal of Medical Virology

436

404

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We aim to summarize reliable evidence of evidence-based medicine for the treatment and prevention of the 2019 novel coronavirus (2019-nCoV) by analyzing all the published studies on the clinical characteristics of patients with 2019-nCoV. PubMed, Cochrane Library, Embase, and other databases were searched. Several studies on the clinical characteristics of 2019-nCoV infection were collected for meta-analysis. Ten studies were included in the meta-analysis, including a total number of 50 466 patients with 2019-nCoV infection. Meta-analysis shows that among these patients, the incidence of fever was 89.1%, the incidence of cough was 72.2%, and the incidence of muscle soreness or fatigue was 42.5%. The incidence of acute respiratory distress syndrome (ARDS) was 14.8%, the incidence of abnormal chest computer tomography (CT) was 96.6%, the percentage of severe cases in all infected cases was 18.1%, and the case fatality rate of patients with 2019-nCoV infection was 4.3%. Fever and cough are the most common symptoms in patients with 2019-nCoV infection, and most of these patients have abnormal chest CT examination. Several people have muscle soreness or fatigue as well as ARDS. Diarrhea, hemoptysis, headache, sore throat, shock, and other symptoms only occur in a small number of patients. The case fatality rate of patients with 2019-nCoV infection is lower than that of the severe acute respiratory syndrome and Middle East respiratory syndrome. K E Y W O R D S 2019-nCoV, clinical symptoms, coronavirus, meta-analysis

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“…[4][5][6][7][8] As SARS is a disease that has recently emerged, the long-term sequelae are largely unclear. Studies on the lung function outcome of SARS survivors have been reported; [9][10][11][12][13][14][15][16][17][18][19] however, the longest duration of follow up was around 3 years and small numbers of subjects were studied. 18,19 We have previously reported the 6 month 12 and 1 year outcomes 13 from the Prince of Wales Hospital SARS patient cohort, based on the available normative lung function data collected in the 1960s.…”

Section: Introductionmentioning

confidence: 99%

The long‐term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status

et al. 2010

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Follow-up Study on Pulmonary Function and Lung Radiographic Changes in Rehabilitating Severe Acute Respiratory Syndrome Patients After Discharge

Abstract: These findings suggest that lung fibrotic changes caused by SARS disease occurred mostly in severely sick patients and may be self-rehabilitated. D(LCO) scores might be more sensitive than HRCT when evaluating lung fibrotic changes.

Cited by 123 publications

References 7 publications

Serial evaluation of high-resolution CT findings in patients with pneumonia in novel swine-origin influenza A (H1N1) virus infection

Serial evaluation of high-resolution CT findings in patients with pneumonia in novel swine-origin influenza A (H1N1) virus infection

Clinical characteristics of hospitalized patients with SARS‐CoV‐2 infection: A single arm meta‐analysis

The long‐term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status

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