Follow up study of chromosome aberrations in lymphocytes in hospital workers occupationally exposed to low levels of ionizing radiation

Paz‐y‐Miño, César; Leone, Paola; Chávez, M.; Bustamante, Gabriela; Córdova, Augusta; Gutiérrez, Sara; Peñaherrera, Ma.Serena; Sánchez, María Eugenia

doi:10.1016/0165-1161(95)00027-5

Cited by 26 publications

(13 citation statements)

References 17 publications

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“…This may be because DNA repair mechanisms act better at low radiation doses and over a long period of time (1). Everyone bears their own radiation burden, consisting mainly of external exposure in the general and occupational environment and diagnostic x-ray doses.…”

Section: Discussionmentioning

confidence: 99%

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Chromosome Aberrations in Peripheral Blood Lymphocytes of Croatian Hospital Staff Occupationally Exposed to Low Levels of Ionising Radiation

Kašuba

Rozgaj

Jazbec

2008

Archives of Industrial Hygiene and Toxicology

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Medical staff is an occupational group exposed to different agents suspected to induce genetic damage. Among them ionising radiation is the most studied. Cytogenetic analysis of human chromosomes in peripheral lymphocytes allows direct detection of mutation in somatic cells. This study investigated the cytogenetic effects of low-level ionising x-radiation in 48-hour peripheral blood lymphocyte cultures sampled from 765 hospital staff occupationally exposed to several agents known or suspected to induce chromosome damage and compared them with 200 control subjects. The exposed subjects were divided in eight (8) groups according to their specialities and job titles. The exposed groups manifested an increase in all types of chromosome aberrations. Acentric fragments were the most frequent chromosome-type aberration. Dicentric chromosomes were statistically significant only in urologists/gynaecologists. Age and smoking significantly influenced the incidence of dicentrics in the exposed groups. The frequency of ring chromosomes was low in all exposed groups (range: 0-2), and none were found in the control group. These findings indicate the importance of periodic medical checkups of hospital staff occupationally exposed to low doses of ionising radiation. The purpose is to create an individual cytogenetic register, where changes could evidence individual risks.

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Section: Discussionmentioning

confidence: 99%

“…Ionising radiation has been the most studied among them. The late effect of low doses can aid in the formation of very active free radicals that can produce chromosomal aberrations related to complex chromosomal rearrangements (1). Although the doses are reduced nowadays, exposure to ionising radiation still is a potential hazard for hospital workers.…”

mentioning

confidence: 99%

Chromosome Aberrations in Peripheral Blood Lymphocytes of Croatian Hospital Staff Occupationally Exposed to Low Levels of Ionising Radiation

Kašuba

Rozgaj

Jazbec

2008

Archives of Industrial Hygiene and Toxicology

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“…The cultures were maintained for 48 hr at 37°C. Harvesting and staining were performed according to standard techniques implemented in our laboratory (Paz-y-Miño et al 1995. One hundred metaphases per individual were scored.…”

Section: Methodsmentioning

confidence: 99%

Cytogenetic Monitoring in a Population Occupationally Exposed to Pesticides in Ecuador

Paz‐y‐Miño¹,

Bustamante²,

Sánchez³

et al. 2002

Environ Health Perspect

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“…Radiation-induced chromosomal aberrations have been reported in several studies like in our study. [16][17][18][19] The results of this study led us to believe that doses of occupationally exposed ionizing radiation in invasive cardiology laboratory workers are ineffective at inducing SCE frequencies, but can produce chromosomal aberrations. This idea is supported by the study of Perry, et al in which higher doses of ionizing radiation were able to affect SCE frequencies and chromosomal aberrations.…”

Section: Discussionmentioning

confidence: 99%

“…[11][12][13][14][15][16][17][18][19] Ionizing radiation can cause chromosome breaks at any stage of the mitotic cycle or during meiosis. It is believed a chromosome is broken when it is hit directly by an ion or an ion cluster.…”

mentioning

confidence: 99%

Sister Chromatid Exchange Analysis and Chromosoma Aberration Studies in Interventional Cardiology Laboratory Workers. One Year Follow up Study.

et al. 2002

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SUMMARYInvasive cardiology laboratory workers are occupationally exposed to chronic ionizing radiation. It is known that ionizing radiation has a damaging effect on chromosomes. In present study, we investigated the frequency of sister chromatid exchange (SCE) and chromosomal aberrations in 11 invasive cardiology laboratory workers and 11 healthy controls. After a vacation period, we took blood samples for chromosome analysis in months 0, 4, 8 and 12 (last two month period was the nonradiation time).The SCE frequencies did not change significantly after exposure to ionizing radiation in any worker. Our study has revealed that non-specific structural chromosome aberrations such as gaps, isogaps, acentric chromosomes, chromatids and chromosome breakage could be in the 4 th and 8 th months after ionizing radiation exposure in the metaphase plaques. All abnormal chromosomal effects had disappeared by the end of the two month non-exposure period in each worker.In conclusion, the results suggest that SCE frequencies are not significantly affected in invasive cardiology laboratory workers who are exposed occupationally to ionizing radiation, although some degree of reversible chromosomal aberrations did appear. (Jpn Heart J 2002; 43: 159-166)

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Follow up study of chromosome aberrations in lymphocytes in hospital workers occupationally exposed to low levels of ionizing radiation

Cited by 26 publications

References 17 publications

Chromosome Aberrations in Peripheral Blood Lymphocytes of Croatian Hospital Staff Occupationally Exposed to Low Levels of Ionising Radiation

Chromosome Aberrations in Peripheral Blood Lymphocytes of Croatian Hospital Staff Occupationally Exposed to Low Levels of Ionising Radiation

Cytogenetic Monitoring in a Population Occupationally Exposed to Pesticides in Ecuador

Sister Chromatid Exchange Analysis and Chromosoma Aberration Studies in Interventional Cardiology Laboratory Workers. One Year Follow up Study.

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