Follow-up Studies of Patients Treated by X-Ray Epilation for Tinea Capitis

Albert, Roy E.; Shore, Roy E.; Harley, Naomi H.; Omran, A R

doi:10.1007/978-1-4684-5269-3_1

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…There was no significant dose-response for malignant brain tumours, and there were statistically significant differences between the risk coefficients for benign and malignant Japanese A-bomb Ն15 at exposure (Thompson et al, 1994) 3 15.0-Ͼ67.2 (32.9) 0.34 (Ͻ0, 1.52) 0.13 (Ͻ0, 0.52) Japanese A-bomb total (Thompson et al, 1994) Israeli tinea capitis children (Ron et al, 1988) 0-15 (7.3) 4.1 (2.9, 5.4) 4 -New York tinea capitis children (Albert et al, 1986) 1-19 (7.7) 3.4 (0.9, 7. brain tumours. There was no significant curvature in the radiation dose-response, whether linear or log-linear models were employed; nor were there significant modifications to the ionising radiation dose-response by number of dose fractions, sex, country of treatment, time since exposure, or age at exposure.…”

Section: Discussionmentioning

confidence: 99%

Risks of brain tumour following treatment for cancer in childhood: Modification by genetic factors, radiotherapy and chemotherapy

Little¹,

et al. 1998

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Section: Discussionmentioning

confidence: 99%

Risks of brain tumour following treatment for cancer in childhood: Modification by genetic factors, radiotherapy and chemotherapy

Little¹,

et al. 1998

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“…Exposure to high doses of ionizing radiation, either due to nuclear disasters [31] or in cancer therapies [32][33][34][35], is a rare and known environmental risk factor for acute myeloid leukemia in childhood [1] and second primary neoplasms (SPNs) [1,29,[36][37][38][39]41]. Indeed gene-radiation interactions are assumed to be involved in the etiology of childhood cancer [1,42] and SPNs [43][44][45][46] as well.…”

Section: Introductionmentioning

confidence: 99%

Identification of Genetic Predispositions Related to Ionizing Radiation in Primary Human Skin Fibroblasts From Survivors of Childhood and Second Primary Cancer as Well as Cancer-Free Controls: Protocol for the Nested Case-Control Study KiKme (Preprint)

Marron¹,

Brackmann²,

Schwarz³

et al. 2021

Preprint

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BACKGROUND Therapy of a first primary neoplasm (FPN) in childhood with high doses of ionizing radiation is an established risk factor for second primary neoplasms (SPN). An association between exposure to low doses and childhood cancer is also suggested, however, results are inconsistent. As only subgroups of children with FPNs develop SPNs, an interaction between radiation, genetic, and other risk factors is presumed to influence cancer development. OBJECTIVE Therefore, the population-based nested case-control study KiKme aims to identify differences in genetic predispositions and radiation-response between childhood cancer survivors with and without SPNs as well as cancer-free controls. METHODS We conducted a population-based nested case-control study KiKme. Besides questionnaire information, skin biopsies and saliva samples are available. By measuring individual reactions to different exposures of radiation (e.g., 0.05 and 2 Gray) in normal somatic cells of the same person, our design enables us to create several exposure scenarios for the same person simultaneously and measure several different molecular markers (e.g., deoxyribonucleic acid (DNA), messenger RNA, long non-coding RNA, copy number variation). RESULTS Since 2013, 101 out of 247 invited SPN patients, 340 out of 1,729 invited FPN patients, and 150 out of 246 invited cancer-free controls were recruited and matched by age and sex. Childhood cancer patients were additionally matched by tumor morphology, year of, and age at diagnosis. Participants reported on lifestyle, socio-economical and anthropometric factors, as well as on medical radiation history, health, and family history of diseases (N = 556). Primary human fibroblasts from skin biopsies of the participants were cultivated (N = 499) and cryopreserved (N = 3,886). DNA was extracted from fibroblasts (N = 488) and saliva (N = 510). CONCLUSIONS This molecular-epidemiological study is the first to combine observational epidemiological research with standardized experimental components in primary human skin fibroblasts to identify genetic predispositions related to ionizing radiation in childhood and SPNs. In the future, fibroblasts of the participants will be used for standardized irradiation experiments, which will inform analysis of the case-control study and vice versa. Differences between participants will be identified using several molecular markers. With its innovative combination of experimental and observational components, this new study will provide valuable data to forward research on radiation-related risk factors in childhood cancer and SPNs.

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“…The prognosis for children with this disease, unlike that for children with leukemia or lymphoma, has not improved substantially in recent decades [ 19]. Much of the information on this association comes from studies of cohorts of children who were exposed in utero when their mothers had X-ray pelvimetry late in pregnancy [26(16] and of cohorts of children who received X-ray treatment for ringworm of the scalp [2,21,25]. Although brain and nervous system tumors remain an important cause of death and disability in children aged 0-14, little is known about the causes of these tumors, which occur predominantly in the brain.…”

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confidence: 99%

The epidemiology of primary nervous system tumors in children

Preston‐Martin

1985

Ital J Neuro Sci

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A study of the descriptive epidemiology of primary tumors of the brain and nervous system in children aged 0-14 was undertaken using international incidence data. The median cumulative incidence rates for this age group were found to be 0.47 per thousand for boys and 0.39 per thousand for girls with a male: female sex ratio of 1.2. Variation in incidence rates by geographic area and race are discussed and are compared to descriptive findings for tumors of this site among adults. Data on suggested risk factors for childhood brain tumors are reviewed.

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Follow-up Studies of Patients Treated by X-Ray Epilation for Tinea Capitis

Cited by 6 publications

References 25 publications

Risks of brain tumour following treatment for cancer in childhood: Modification by genetic factors, radiotherapy and chemotherapy

Risks of brain tumour following treatment for cancer in childhood: Modification by genetic factors, radiotherapy and chemotherapy

Identification of Genetic Predispositions Related to Ionizing Radiation in Primary Human Skin Fibroblasts From Survivors of Childhood and Second Primary Cancer as Well as Cancer-Free Controls: Protocol for the Nested Case-Control Study KiKme (Preprint)

The epidemiology of primary nervous system tumors in children

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