Follow‐up of the monitored levels of preservative sensitivity in Europe. Overview of the years 2001–2008

Svedman, Cecilia; Andersen, Klaus Ejner; Brandão, Francisco Menezes; Bruynzeel, Derk P.; Diepgen, Thomas L.; Frosch, Peter J.; Rustemeyer, Thomas; Giménez‐Arnau, Ana; Gonçalo, Margarida; Goossens, An; Johansen, Jeanne Duus; Lahti, Arto; Menné, Torkil; Seidenari, Stefania; Tosti, Antonella; Wahlberg, Jan E.; White, Ian R.; Wilkinson, J. D.; Mowitz, Martin; Bruze, M.

doi:10.1111/j.1600-0536.2012.02140.x

Cited by 52 publications

(61 citation statements)

References 19 publications

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“…15,16 In our study, we found the rate among NHCWs to be 4.3% and a statistically increased incidence of 8.5% among HCWs. Formaldehyde, which is present in many medical laboratories and in biocides that may be present in hospitals, likely resulted in this finding.…”

Section: Discussionmentioning

confidence: 83%

Occupational Dermatitis in Health Care Workers Evaluated for Suspected Allergic Contact Dermatitis

Kadivar

Belsito

2015

Dermatitis

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Section: Discussionmentioning

confidence: 83%

Occupational Dermatitis in Health Care Workers Evaluated for Suspected Allergic Contact Dermatitis

Kadivar

Belsito

2015

Dermatitis

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“…There are thus different types of MPTS in which at least two patch test clinics participate. One type involves collecting retrospective data , another type is represented by networks producing patch test data constantly , and a third type is the prospective MPTS on, for example, the concentration (dose/cm 2 ) of a certain sensitizer to be used .…”

Section: Factors Of Significance For the Patch Test Results And Their mentioning

confidence: 99%

Thoughts on how to improve the quality of multicentre patch test studies

Bruze

2016

Contact Dermatitis

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SummaryMulticentre patch test studies (MPTSs) can contribute useful information for diagnostic and preventive measures. The aim of the present paper is to propose how to perform high-quality MPTSs. To this end, factors of significance for the patch test result are discussed with regard to the standardization and calibration of high-quality MPTSs. The 16 factors discussed are scored 0, 1, 2, or 3, depending on the relative importance of a particular factor for the patch test result. The total score of an MPTS allows it to be ranked as having doubtful, acceptable, high or excellent quality. A total score of 30 is possible. Depending on the total score the MPTSs are grouped into those with a doubtful, acceptable, high, and excellent quality. In conclusion, high-quality MPTSs can be performed and are facilitated if a guideline and check list are followed when the study is being planned. The scoring enables the calculation of a total score, which can be used for quality ranking.

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“…In that article we concluded that the most likely explanation was a cross-reaction between MCI and MI (9). The banning of methyldibromo glutaronitrile in cosmetics by the EU has resulted in a come back of the strong allergenic mixture of MCI/MI (5,10,11). MI alone has recently been introduced in cosmetics to replace the mixture MCI/MI, since it is less allergenic.…”

Section: Discussionmentioning

confidence: 93%

“…In a recent publication on MI (18) it was discussed why the increase in incidence of contact allergy to MI (5,10,11,(15)(16)(17) has happened, and it was concluded that it probably could be explained by the fact that the use of cosmetics preserved with MI has increased (19,20) and that a substantial proportion contains more than 10-20 ppm (19).…”

Section: Discussionmentioning

confidence: 96%

Methylisothiazolinone Contact Allergy is Rising to Alarming Heights Also in Southern Sweden

Isaksson¹,

Hauksson²,

Hindsén³

et al. 2015

Acta Derm Venerol

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The preservative methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is a well-known sensitiser and present in most baseline series since at least 20 years. The proportions of MCI/MI are 3:1. MI alone has been used as a preservative in occupational and household products, and cosmetics since less than 10 years. MCI/MI tested at 100 ppm fails to detect a significant percentage of contact-allergic reactions to MI. Our aim was to investigate whether a separate test preparation with MI picks up additional cases of contact allergy to MI not detected with MCI/MI 200 ppm. MI was inserted into the baseline series of the Malmö clinic in 2003 starting at 475 ppm, then 900 ppm, then 1,000 ppm, 1,500 ppm and finally 2,000 ppm. In 5,881 consecutively tested dermatitis patients the contact allergy rate for MI varied between 0.5 and 6.5%, with a marked increase in recent years. The contact allergy rate to MI 2,000 ppm alone, not traced by MCI/MI 200 ppm, varied between 0 and 1.9 %. In conclusion, due to the increase of contact allergy to MI not traced by MCI/MI 200 ppm, MI in water at 2,000 ppm should be tested in a baseline series. Independent of patch test technique a dose of 60 µg/cm should not be exceeded to avoid adverse reactions and particularly patch test sensitisation.

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Follow‐up of the monitored levels of preservative sensitivity in Europe. Overview of the years 2001–2008

Cited by 52 publications

References 19 publications

Occupational Dermatitis in Health Care Workers Evaluated for Suspected Allergic Contact Dermatitis

Occupational Dermatitis in Health Care Workers Evaluated for Suspected Allergic Contact Dermatitis

Thoughts on how to improve the quality of multicentre patch test studies

Methylisothiazolinone Contact Allergy is Rising to Alarming Heights Also in Southern Sweden

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