Follow‐up of solar lentigo depigmentation with a retinaldehyde‐based cream by clinical evaluation and calibrated colour imaging

Questel, Emmanuel; Durbise, E.; Bardy, A.; Schmitt, Anne-Marie; Josse, Gwendal

doi:10.1111/srt.12182

Cited by 5 publications

(4 citation statements)

References 21 publications

(27 reference statements)

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“…It has been shown to be a precise and robust technique for skin lightening efficacy evaluation [8,22,27,39]. Pierre Fabre imaging team previously showed that precise skin color measurements can be performed using a high-magnification color-calibrated camera, also used to follow up lentigines [20]. The present study includes this new technology.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of D-pigment dermocosmetic lightening product for solar lentigo lesions of the hand: A randomized controlled trial

et al. 2019

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Solar lentigo, benign lesions which mostly appear on chronically, sun-exposed surfaces, are associated with ageing. Patients are increasingly requesting a more uniform skin texture, especially for hands. Treatment options include dermoabrasion, intense pulsed light, cryotherapy, peelings, and laser therapy. Topical compounds can be employed, in alternative or associated with dermatologic procedures. The current study was designed to evaluate solar lentigo hyperpigmentation, skin architecture and clinician and patient assessments comparing a dermocosmetic lightening product (active) with a moisturizing product (control) according to clinical, digital and subjective analyses in 72 lesions over 12-month follow up period. Statistically significant differences were observed between the lesions treated with the active compared to the control in terms of papillary brightness (p = 0.03) and contrast (p = 0.03), and in the limitation of dermal-epidermal junction destructuring (p = 0.03) according to dermal-epidermal junction destructuring score at Reflectance Confocal Microscopy. Luminance (p = 0.04) and redness (p = 0.03) were improved at color analysis, and physician and patient evaluations favored the active in efficacy and patient satisfaction investigations. The dermocosmetic lightening product utilized in the current study proved to be more effective, according to clinical, digital and subjective analyses in reducing lesion hyperpigmentation, stabilizing the lesion skin architecture and increasing patient satisfaction compared to the control in a cohort of 36 subjects, over a 12-month period. Beside demonstrating the efficacy of this topical lightening product, we propose a “destructuring score”, which improves the robustness of solar lentigo’s evaluation, and can be used in future studies to standardize the quantitative comparisons of different treatment options.

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Section: Discussionmentioning

confidence: 99%

Efficacy of D-pigment dermocosmetic lightening product for solar lentigo lesions of the hand: A randomized controlled trial

et al. 2019

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“…whereas it tended to decrease on lentigines treated by the day cream (∆C = −3.8 ± 3.1, P = .075). The difference in contrast over time between the two hands was not statistically significant, possibly due to the relatively small number of volunteers that could be analyzed (6). On the non-treated hand, the increase in contrast reflected the increase in melanin synthesis around the papillae.…”

Section: Reflectance Confocal Microscopymentioning

confidence: 86%

“…We recently showed that the color-calibrated camera is an efficient imaging system for following lentigines' pigmentation over time because the lesion can be precisely segmented. 6 It has to be remembered that even if the chromameter gives a robust color measurement, it is only performed on a small fixed spot of few millimeters, but it does not take into account the entire lentigo with its detailed shape. High magnification color-calibrated camera, however, does take this shape into account quite clearly.…”

Section: Discussionmentioning

confidence: 99%

“…Non‐invasive imaging techniques have been shown to be very useful in analyzing the structures of pigmented lesions and in assessing the treatments' efficacy. Color measurements are usually performed with chromameters or with color calibrated camera . In vivo reflectance confocal microscopy (RCM) enables non‐invasive imaging of in‐depth skin structure.…”

Section: Introductionmentioning

confidence: 99%

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Protection against summer solar lentigo over‐pigmentation with a SPF30 daily cream

Josse

Digabel

Questel

2018

Skin Research and Technology

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Topical Cosmeceutical Retinoids

Sorg¹,

Kaya²,

Saurat³

2022

Cosmetic Dermatology

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Follow‐up of solar lentigo depigmentation with a retinaldehyde‐based cream by clinical evaluation and calibrated colour imaging

Abstract: High-magnification colour-calibrated camera imaging combined with probability map analysis is a fast and precise method to follow lentigo depigmentation.

Cited by 5 publications

References 21 publications

Efficacy of D-pigment dermocosmetic lightening product for solar lentigo lesions of the hand: A randomized controlled trial

Efficacy of D-pigment dermocosmetic lightening product for solar lentigo lesions of the hand: A randomized controlled trial

Protection against summer solar lentigo over‐pigmentation with a SPF30 daily cream

Topical Cosmeceutical Retinoids

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