Follow-up of negative MRI-targeted prostate biopsies: when are we missing cancer?

Gold, Samuel; Hale, Graham; Bloom, Jonathan; Smith, Clayton; Rayn, Kareem; Valera, Vladimir; Wood, Bradford J.; Choyke, Peter L.; Türkbey, Barış; Pinto, Peter A.

doi:10.1007/s00345-018-2337-0

Cited by 32 publications

(14 citation statements)

References 32 publications

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“…Recent studies have evaluated that the failure rate of the imaging-guided pathway for detecting index lesions can be estimated at 20% [12]. Indeed, potential sources of error can arise from each step of the imaging-based strategy and may explain the remaining inaccuracy of TB for both detection and accurate prognostic evaluation [11]. Several studies have suggested that TB and SB techniques are complementary and should be offered together, given their variable performances depending the tumor location and other factors [16,18].…”

Section: Discussionmentioning

confidence: 99%

“…Finally, the realization of concomitant systematic biopsy (SB) could also influence this ideal TB core number and improve grading prediction. Indeed, SBs are still recommended in addition to TB, aimed at correction of targeting errors and/or false negative areas on imaging, and could limit the interest of a "saturation" TB scheme of the visible lesion [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction

Ploussard

Beauval

Renard-Penna

et al. 2020

JCM

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Background: To study the impact of MRI characteristics and of targeted biopsy (TB) core number on the final grade group (GG) prediction. Materials and Methods: The cohort was 478 consecutive patients who underwent radical prostatectomy (RP) after positive mpMRI (multiparametric magnetic resonance imaging) followed by fusion TB. Endpoints were the upgrading and concordance rates between TB and RP specimens. Results: Upgrading rate after TB was 40.6%. Patients with upgrading had lower PIRADS (Prostate Imaging-Reporting and Data System) scores (p < 0.001), smaller lesion size (p = 0.017), fewer TB cores (p < 0.001), and lower TB density (p = 0.015) compared with cases with grade concordance. There was a significant continuous improvement in upgrading rate when TB core number per lesion increased from 56.3% to 25.6% when <2 or ≥5 TB cores were taken, respectively (p = 0.002). The minimal TB number per lesion to reduce upgrading risk to approximately 30%was 4 in PIRADS 3, and 3 in PIRADS 4–5 cases. Conclusions: Grade group prediction by TB is significantly improved by higher PIRADS score, larger lesion size, and increased TB per lesion. At least four TB cores should be taken in PIRADS 3 score lesions, whereas three cores seem enough in PIRADS 4–5 cases to improve GG prediction and limit upgrading risk.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction

Ploussard

Beauval

Renard-Penna

et al. 2020

JCM

View full text Add to dashboard Cite

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“…Imaging, and in particular multiparametric 1 H MRI, plays a prominent role in active surveillance because of its ability to localize aggressive focal lesions within the prostate for focal therapy [4]. Nevertheless, prostate MRI still suffers from a high incidence of both false positive [5] and false negative [6] events, requiring other biomarkers and associated imaging techniques for delineation of focal lesions.…”

Section: Introductionmentioning

confidence: 99%

Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer

et al. 2019

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There is an unmet clinical need for new and robust imaging biomarkers to distinguish indolent from aggressive prostate cancer. Hallmarks of aggressive tumors such as a decrease in extracellular pH (pHe) can potentially be used to identify aggressive phenotypes. In this study, we employ an optimized, high signal-to-noise ratio hyperpolarized (HP) 13C pHe imaging method to discriminate between indolent and aggressive disease in a murine model of prostate cancer. Transgenic adenocarcinoma of the mouse prostate (TRAMP) mice underwent a multiparametric MR imaging exam, including HP [13C] bicarbonate MRI for pHe, with 1H apparent diffusion coefficient (ADC) mapping and HP [1-13C] pyruvate MRI to study lactate metabolism. Tumor tissue was excised for histological staining and qRT-PCR to quantify mRNA expression for relevant glycolytic enzymes and transporters. We observed good separation in pHe between low- and high-grade tumor regions, with high-grade tumors demonstrating a lower pHe. The pHe also correlated strongly with monocarboxylate transporter Mct4 gene expression across all tumors, suggesting that lactate export via MCT4 is associated with acidification in this model. Our results implicate extracellular acidification as an indicator of indolent-to-aggressive transition in prostate cancer and suggest feasibility of HP pHe imaging to detect high-grade, clinically significant disease in men as part of a multiparametric MRI examination.

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“…[23][24][25][26][27] The incorporation of Au into cancer cells is considered as a promising treatment method as Au is one of the essential elements for cell cycle progression in the human body. [28][29][30][31][32] On the other hand, among a wide range of nanocomposites, graphene derivatives have received signicant attention and research focus in diverse application areas, including nanomedicine, due to their extraordinary physical and optical characteristics. [33][34][35] Intensive research has been applied to investigate the biomedical application of graphene-based nanomaterials as drug-delivery vehicles for cancer treatment, which is considered as a novel therapeutic aspect for performing nanoscale-based chemotherapy coupled with photothermal therapy.…”

Section: Introductionmentioning

confidence: 99%

A graphene gold nanocomposite-based 5-FU drug and the enhancement of the MCF-7 cell line treatment

et al. 2019

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Follow-up of negative MRI-targeted prostate biopsies: when are we missing cancer?

Abstract: A better understanding of these potential pitfalls in the mpMRI-guided Tbx procedure will aid interpretation of a negative Tbx, identify areas for improving technical proficiency, and improve both physician understanding of negative Tbx and patient-management options.

Cited by 32 publications

References 32 publications

Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction

Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction

Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer

A graphene gold nanocomposite-based 5-FU drug and the enhancement of the MCF-7 cell line treatment

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