“…(Al-Nouri et al, 2015;Ali et al, 2013;Bren et al, 2005;Caires et al, 2012;Cortina et al, 2015;Furmanczyk et al, 2009;Gray and Ameduri, 2016;Lin et al, 2003;Parissis et al, 2010;Ponticelli, 2007;Said et al, 2010;Zarifian et al, 1999) The primary aim of this thesis is to examine whether cyclosporine exposure lead to complementmediated endothelial cell injury and to elucidate the mechanism by which complement dysregulation is induced. To achieve this, we used an in vitro model of disease that utilizes human blood outgrowth endothelial cells (BOEC), because they are an endothelial progenitor cell that can be isolated from patients.…”