Follow-Up of High-Intensity Focused Ultrasound Treatment for Patients with Hepatocellular Carcinoma

Xu, Guoliang; Luo, Guangyu; He, Longjun; Li, Jianjun; Shan, Hong; Zhang, Rong; Li, Yin; Gao, Xiaoyan; Lin, Sensen; Wang, Guobao

doi:10.1016/j.ultrasmedbio.2011.08.011

Cited by 45 publications

(35 citation statements)

References 20 publications

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“…HIFU demonstrates advantages in tumor treatment (24)(25)(26). However, HIFU has significant side-effects such as long treatment times that result in dermal burns and lack of absorption by necrotic tumor tissue (27,28). During the clinical application of HIFU, it was discovered that the fringe area of tumor tissue treated by LIPUS was more sensitive to anticancer drugs.…”

Section: Discussionmentioning

confidence: 99%

Study of the mechanisms underlying the reversal of multidrug resistance of human neuroblastoma multidrug-resistant cell line SK-N-SH/MDR1 by low-intensity pulsed ultrasound

et al. 2013

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Abstract. The aim of the present study was to investigate the underlying mechanism(s) involved in reversing multidrug resistance (MDR) of SK-N-SH/MDR1 by low-intensity pulsed ultrasound (LIPUS). Membrane alteration of SK-N-SH/ MDR1 cells exposed to LIPUS was analyzed by scanning electron microscopy (SEM). Immunofluorescence and western blotting were used\ to detect changes in the expression of the MDR-related proteins P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1) and glutathione-S-transferase-π (GST-π) after the optimum ultrasonic. The optimum ultrasonic conditions were 0.3 MHz, 1.0 W/cm 2 , 40 sec and the chemosensitivity of SK-N-SH/MDR1 cells was significantly increased (P<0.05). The optimum ultrasonic-induced perforation of the irradiated cell membranes was observed by SEM. The expression of P-gp was significantly decreased in the group treated by optimum ultrasonic (P<0.05), but not the expressions of MRP1 or GST-π (P>0.05). We demonstrated that LIPUS effectively reverses the MDR of SK-N-SH/MDR1, presumably via augmenting membrane permeability and decreasing the P-gp expression of SK-N-SH/MDR1.

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Section: Discussionmentioning

confidence: 99%

Study of the mechanisms underlying the reversal of multidrug resistance of human neuroblastoma multidrug-resistant cell line SK-N-SH/MDR1 by low-intensity pulsed ultrasound

et al. 2013

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“…Planned iatrogenic right hydrothorax with intra-pleural infusion of warm saline solution was reported in 272 cases, to enhance HIFU coupling in cases of liver dome tumor (26,35,36,38,41,45,52,55,75). Other studies reported on the use of artificial pleural infusion or artificial ascites in selected cases, without detailing the number of patients (42)(43)(44)49,51).…”

Section: Records Included For Qualitative Synthesis N=67mentioning

confidence: 99%

High intensity focused ultrasound (HIFU) applied to hepato-bilio-pancreatic and the digestive system—current state of the art and future perspectives

Diana¹,

Schiraldi²,

Liu³

et al. 2016

Hepatobiliary Surg. Nutr.

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Background: High intensity focused ultrasound (HIFU) is emerging as a valid minimally-invasive imageguided treatment of malignancies. We aimed to review to current state of the art of HIFU therapy applied to the digestive system and discuss some promising avenues of the technology.Methods: Pertinent studies were identified through PubMed and Embase search engines using the following keywords, combined in different ways: HIFU, esophagus, stomach, liver, pancreas, gallbladder, colon, rectum, and cancer. Experimental proof of the concept of endoluminal HIFU mucosa/submucosa ablation using a custom-made transducer has been obtained in vivo in the porcine model. Results:Forty-four studies reported on the clinical use of HIFU to treat liver lesions, while 19 series were found on HIFU treatment of pancreatic cancers and four studies included patients suffering from both liver and pancreatic cancers, reporting on a total of 1,682 and 823 cases for liver and pancreas, respectively. Only very limited comparative prospective studies have been reported. Conclusions:Digestive system clinical applications of HIFU are limited to pancreatic and liver cancer. It is safe and well tolerated. The exact place in the hepatocellular carcinoma (HCC) management algorithm remains to be defined. HIFU seems to add clear survival advantages over trans arterial chemo embolization (TACE) alone and similar results when compared to radio frequency (RF). For pancreatic cancer, HIFU achieves consistent cancer-related pain relief. Further research is warranted to improve targeting accuracy and efficacy monitoring. Furthermore, additional work is required to transfer this technology on appealing treatments such as endoscopic HIFU-based therapies.Keywords: High intensity focused ultrasound (HIFU); liver cancer; pancreatic cancer; miniature HIFU delivery system; endoluminal applications of HIFU; mucosa and submucosal ablations using HIFU

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“…ChildPugh class A patients with tumor size ≤ 3 cm and a well-differentiated histologic pattern who achieved an initially complete ablation had median survival of 65 mo. Median time to recurrence was 24 mo, and median disease-free survival was 26 mo [55] . However, this form of treatment is not preferred, largely due to the availability of better alternative ablative therapies.…”

Section: Figure 2 Axial Computed Tomography Images Before and After Rmentioning

confidence: 99%

Locoregional treatment for hepatocellular carcinoma: The best is yet to come

Kalra

Gupta

Chawla

et al. 2015

WJR

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Follow-Up of High-Intensity Focused Ultrasound Treatment for Patients with Hepatocellular Carcinoma

Cited by 45 publications

References 20 publications

Study of the mechanisms underlying the reversal of multidrug resistance of human neuroblastoma multidrug-resistant cell line SK-N-SH/MDR1 by low-intensity pulsed ultrasound

Study of the mechanisms underlying the reversal of multidrug resistance of human neuroblastoma multidrug-resistant cell line SK-N-SH/MDR1 by low-intensity pulsed ultrasound

High intensity focused ultrasound (HIFU) applied to hepato-bilio-pancreatic and the digestive system—current state of the art and future perspectives

Locoregional treatment for hepatocellular carcinoma: The best is yet to come

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