2022
DOI: 10.1101/2022.02.25.481941
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Follow-up investigation and detailed mutational characterization of the SARS-CoV-2 Omicron variant lineages (BA.1, BA.2, BA.3 and BA.1.1)

Abstract: Aided by extensive protein mutations, the SARS-CoV-2 Omicron (B.1.1.529) variant overtook the previously dominant Delta variant and rapidly spread around the world. It was shown to exhibit significant resistance to current vaccines and evasion from neutralizing antibodies. It is therefore critical to investigate the Omicron mutations trajectories. In this study, a literature search of published articles and SARS-CoV-2 databases was conducted, We explored the full list of mutations in Omicron BA.1, BA.1.1, BA.2… Show more

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Cited by 16 publications
(26 citation statements)
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References 152 publications
(199 reference statements)
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“…Genomic monitoring of SARS-CoV-2 variants in different regions of the world allows understanding of the dynamics and genetic mechanisms of each variant [1], especially in Omicron, that has several mechanisms to promote increased transmission and immune escape [7,11]. Furthermore, this variant has an estimated transmission rate between 5 and 8 [12], which means that Omicron is transmitted rapidly, leading to an increase in the number of associated cases.…”
Section: Discussionmentioning
confidence: 99%
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“…Genomic monitoring of SARS-CoV-2 variants in different regions of the world allows understanding of the dynamics and genetic mechanisms of each variant [1], especially in Omicron, that has several mechanisms to promote increased transmission and immune escape [7,11]. Furthermore, this variant has an estimated transmission rate between 5 and 8 [12], which means that Omicron is transmitted rapidly, leading to an increase in the number of associated cases.…”
Section: Discussionmentioning
confidence: 99%
“…As for BA.2, it is interesting to note the low number of genomes reported so far and the circulation in only a few countries on the continent (Table S1 and Figure 1b) and the minor divergent cluster (Figure 3). Unlike BA.1 and BA.1.1, this lineage has a greater number of unique mutations, mainly in the Spike gene, promoting more effective immune evasion and transmissibility [7][8][9][10][11][12][13]. Moreover, this number of unique mutations might be contributing to the associated divergent clustering for this lineage, which differs from the other clusters that contain the BA.1 and BA.1.1 genomes.…”
Section: Discussionmentioning
confidence: 99%
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