Follow-Up Factors Contribute to Immunosuppressant Adherence in Kidney Transplant Recipients

Chen, Tingting; Wang, Yuzhu; Tian, Dan; Zhang, Jieqing; Xu, Qing; Lv, Qianzhou; Li, Xiaoyü; Wang, Jina

doi:10.2147/ppa.s383243

Cited by 2 publications

(2 citation statements)

References 22 publications

(37 reference statements)

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“…An indispensable component of kidney graft survival is adherence to the therapeutic regimen, which, although it extends beyond medication adherence to include dietary compliance and lifestyle changes, has mainly been studied on the pharmacological side [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Regimen Adherence and Risk of Renal Graft Loss: Nurse Interventions

Costa¹,

Silva²

2023

Current Challenges and Advances in Organ Donation and Transplantation

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Kidney transplantation is considered the best therapeutic option and survival is dependent on adherence to the drug regimen. Adherence to the therapeutic regime thus becomes the key to success. However, the literature shows that not all patients are adherent, and readmission due to graft dysfunction is a reality. Although a direct relationship between adherence to the therapeutic regimen and graft dysfunction cannot be attributed, the issue of adherence is far from not deserving the attention of health professionals. This text aims to identify the importance of nursing interventions in promoting adherence to the therapeutic regimen. In an exploratory approach to the process of adherence, and reflecting on concordance and its relevance to adherence, given the heterogeneity of both definitions, we aimed to study the nurses’ role and the type of interventions to promote adherence to the therapeutic regimen in transplanted renal patients. We conclude that education and counselling are the predominant interventions and that concordance is part of this practice, where the expected outcome is kidney graft survival as a consequence of adherence to the therapeutic regimen.

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Section: Introductionmentioning

confidence: 99%

Therapeutic Regimen Adherence and Risk of Renal Graft Loss: Nurse Interventions

Costa¹,

Silva²

2023

Current Challenges and Advances in Organ Donation and Transplantation

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“…Few reported studies exist on adherence in Chinese renal transplant recipients, and information on the correlation of IPV with nonadherence is limited [23][24][25][26] . Therefore, the main objectives of this study were to assess the prevalence of nonadherence to immunosuppressives therapy (implementation phase) in Chinese renal transplant recipients, explore the multilevel correlates associated with nonadherence, and investigate the relationship between tacrolimus (Tac) IPV and nonadherence.…”

Section: Introductionmentioning

confidence: 99%

Profiles of Immunosuppressive Nonadherence and Association between Medication Adherence and Tacrolimus Intra-patient Variability Among Stable Kidney Transplant Recipients

Zou,

Dai,

Hou

et al. 2023

Preprint

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Background Understanding the modifiable correlates and risk factors for medication non-adherence is essential to develop interventions to improve adherence and thus long-term transplantation outcomes. Methods This single-center cross-sectional study collected 409 validated questionnaires of renal transplant recipients followed in outpatient clinics. The incidence of nonadherence to immunosuppressive therapy (implementation phase) was calculated. Multilevel correlates associated with nonadherence were collected to analyze multilevel correlates of nonadherence in kidney transplant recipients. The relationship between nonadherence and recipient outcomes was also explore. Results The incidence of nonadherence to immunosuppressive drugs in renal transplant recipients was 41.6%. Multiple logistic regression analysis showed that 4 variables were positively associated with immunosuppressive nonadherence, namely without steady partner (OR: 1.722; 95%CI: 1.034–2.866), post-transplant years (OR: 1.240; 95%CI: 1.134–1.356), twice-daily immunosuppressive regimen (OR: 5.522 95%CI: 2.857–10.671), Tac IPV (OR: 1.029 95%CI: 1.007–1.052). There was a significant difference in Tac IPV between the adherent and nonadherent groups. The incidence of rejection was 4.2% (10/239) in the adherent group and 12.4% (21/170) in the nonadherent group(p = 0.002). In addition, nonadherence (OR: 2.967, 95%CI: 1.248–7.058) and Tac IPV (OR: 1.030, 95%CI: 1.001–1.060) were positively correlated with episodes of rejection. Conclusion The higher incidence of immunosuppression nonadherence in renal transplant recipients correlates with lacking a steady domestic partner, longer time since the transplantation, higher frequency of immunosuppressive dosing, and higher Tac IPV. In addition, nonadherence and higher tacrolimus IPV were correlated with episodes of rejection. Tacrolimus IPV can be an additional instrument for identifying recipients at risk of nonadherence.

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Follow-Up Factors Contribute to Immunosuppressant Adherence in Kidney Transplant Recipients

Cited by 2 publications

References 22 publications

Therapeutic Regimen Adherence and Risk of Renal Graft Loss: Nurse Interventions

Therapeutic Regimen Adherence and Risk of Renal Graft Loss: Nurse Interventions

Profiles of Immunosuppressive Nonadherence and Association between Medication Adherence and Tacrolimus Intra-patient Variability Among Stable Kidney Transplant Recipients

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