Follow-up at age 10years in ELBW children — Functional outcome, brain morphology and results from motor assessments in infancy

Grunewaldt, Kristine Hermansen; Fjørtoft, Toril; Bjuland, Knut Jørgen; Brubakk, Ann‐Mari; Eikenes, Live; Håberg, Asta; Løhaugen, Gro; Skranes, Jon

doi:10.1016/j.earlhumdev.2014.07.005

Cited by 73 publications

(91 citation statements)

References 26 publications

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“…16 Prematurity is known to affect CC development, by the early transition from intrauterine to extrauterine life and by postnatal stress and injury, 17 leading to both structural and functional impairment. 18,19 Associations have been found between the length and thickness of the CC and brain volumes and neurodevelopmental outcome. 11,20,21 Further studies should elucidate whether CC length can be considered a proxy of telencephalon development, creating an impression of white matter development and brain maturation.…”

Section: Discussionmentioning

confidence: 99%

A New Ultrasound Marker for Bedside Monitoring of Preterm Brain Growth

Roelants

Koning²,

Raets

et al. 2016

American Journal of Neuroradiology

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Section: Discussionmentioning

confidence: 99%

A New Ultrasound Marker for Bedside Monitoring of Preterm Brain Growth

Roelants

Koning²,

Raets

et al. 2016

American Journal of Neuroradiology

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“…Meta-analyses reveal reductions of total brain volume, white and gray matter, cerebellum, hippocampus, caudate and corpus callosum, 2,3 and these changes seem to persist into adolescence. [4][5][6][7][8][9][10] Alterations in brain structures correlate with intellectual and motor abilities in preterm infants. [11][12][13][14] The neuropathology of brain development in premature infants reflects multiple factors.…”

Section: What This Study Addsmentioning

confidence: 99%

Long-Chain Polyunsaturated Fatty Acids and Cognition in VLBW Infants at 8 years: an RCT

et al. 2015

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OBJECTIVE: To test the hypothesis that supplementation with the long chain polyunsaturated fatty acids docosahexaenoic acid (DHA) and arachidonic acid (AA) to very low birth weight (VLBW) infants would improve long-term cognitive functions and influence neuroanatomical volumes and cerebral cortex measured by MRI. METHODS:The current study is a follow-up of a randomized, double-blinded, placebo-controlled study of supplementation with high-dose DHA (0.86%) and AA (0.91%) to 129 VLBW infants fed human milk. Ninety-eight children participated at 8 years follow-up and completed a broad battery of cognitive tests. Eighty-one children had cerebral MRI scans of acceptable quality.RESULTS: There were no significant differences between the intervention group and the control group on any of the cognitive measures. Equally, MRI data on segmental brain volumes and cerebral cortex volume, area, and thickness suggested no overall group effect.CONCLUSIONS: This study is the first long-term follow-up of a randomized controlled trial with supplementation of DHA and AA to human milk fed VLBW infants investigating both cognitive functions and brain macrostructure measured by MRI. No cognitive or neuroanatomical effects of the supplementation were detected at 8 years of age.

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“…Reduced volumes of posterior corpus callosum, as well as reductions in size of globus pallidus and cerebellar white matter have been discovered on cerebral magnetic resonance imaging (MRI) of non cerebral palsy ELBW children at 10 years of age (Grunewaldt et al, 2014). In terms of how these differences translate to a functional context, a significant correlation between verbal IQ and verbal fluency scores and the size of the posterior half of the corpus callosum has been demonstrated (Nosarti et al, 2004).…”

Section: Biological Factorsmentioning

confidence: 99%

“…However, although it appears that major disabilities amongst this population have stayed fairly constant over the past decade, the incidence of milder problems appears to be rising (Saigal & Doyle, 2008). It has been reported that up to 50% of very low birth weight (VLBW) children can present with problems of motor co-ordination, postural stability, attention and fitness from the age of three and four years, through school age and adolescence, and even into adulthood (Bos & Roze, 2011;Bracewell & Marlow, 2002;Burns et al, 2004;Burns et al, 2009;Danks, 2010;Goyen & Lui, 2009;Grunewaldt et al, 2014;Hack et al, 2002;Keller et al, 1998;Powls et al, 1995;Shumway-Cook et al, 2003;Spittle et al, 2009). For the purpose of this thesis, the emphasis will be on the following neurodevelopmental domains: motor, postural stability, and behaviour, cognitive function and attention.…”

Section: What This Paper Addsmentioning

confidence: 99%

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Physiotherapy intervention for 4-5 year old children born extremely preterm and/or extremely low birth weight

Brown¹

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Neurodevelopmental impairments amongst the extremely low birth weight (ELBW) or extremely preterm population are well recognised. However, support services for these children who have mild impairments are lacking. This research aimed to explore the performance of a group of non-disabled ELBW or extremely preterm children with minimal/mild impairments over a 12 month period at a critical time-point, coinciding with the commencement of formal education. Performance of these children was established, as well as whether impairments persist. Persistence of impairments may suggest a widening gap between performance of these children and expected performance of term born peers. Additionally, this research aimed to investigate the short term and longer term impact of group-based physiotherapy intervention compared to standard care. SubjectsFifty children born ELBW and/or extremely preterm (26 males; mean birth weight: 838.8g, SD 174.8g; mean gestational age: 27.0 weeks, SD 2.0 weeks) with minimal/mild motor impairments and a mean age (corrected for prematurity) of 50 months (SD 2.6 months) at baseline. Twenty-four children were randomised to intervention and 26 children to standard care. MethodsChildren were assessed by paediatric physiotherapists blinded to group allocation. A set testing protocol was used. Baseline assessment included: Movement Assessment Battery for Children second-edition (MABC-2), tests of postural stability and limb strength, Child Behavior Checklist (CBCL) and Beery Visual-Motor Integration Test 5 th Edition (Beery VMI). Following baseline assessment, children were randomly allocated to intervention or standard care. All children were assessed on motor and postural tests at the conclusion of the intervention. Goal Attainment Scaling (GAS) was utilised within the intervention group. At one year post baseline assessment, all children were assessed on baseline tests, as well as Peabody Picture Vocabulary Test 4 th Edition (PPVT-4). The group had low average motor co-ordination, lower than expected postural stability and strength, and acceptable behaviour. Mean percentile rank on MABC-2 was 31%.However, 30% of children had a score less than or equal to the 15 th percentile, indicating at risk of or having a definite motor problem and these children had poorer postural outcomes compared to children with normal motor performance. Behaviour was within normal range according to performance on CBCL, although between 11-15% of children had a score within the clinical range. Behaviour of males was poorer than that of females. Study IV: GAS to explore effect of group-based physiotherapy intervention on personal growth of non-disabled ELBW children Intervention was effective with GAS mean T score of the group exceeding the expected level (mean=58.17, SD=0.82). Goal attainment was associated with motor co-ordination 4 and children with better motor skills post intervention, were more successful in reaching goals. Females improved more than males on GAS. Study V: Behaviour of 4-5 year old non-disabled E...

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Follow-up at age 10years in ELBW children — Functional outcome, brain morphology and results from motor assessments in infancy

Cited by 73 publications

References 26 publications

A New Ultrasound Marker for Bedside Monitoring of Preterm Brain Growth

A New Ultrasound Marker for Bedside Monitoring of Preterm Brain Growth

Long-Chain Polyunsaturated Fatty Acids and Cognition in VLBW Infants at 8 years: an RCT

Physiotherapy intervention for 4-5 year old children born extremely preterm and/or extremely low birth weight

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