Follow-up after curative treatment for oral squamous cell carcinoma. A critical appraisal of the guidelines and a review of the literature

Brands, Marieke T.; Brennan, Peter A.; Verbeek, A.L.M.; Merkx, M.A.W.; Geurts, S.M.E.

doi:10.1016/j.ejso.2018.01.004

Cited by 64 publications

(72 citation statements)

References 69 publications

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“…Oral squamous cell carcinoma (OSCC), a common subset of head and neck squamous cell carcinoma (HNSCC), is well‐known for resistance to apoptosis, high rate of lymph node metastasis, and local invasiveness . Its 5‐year survival rate is merely 50%, although clinical diagnosis and therapy strategies have been improved . Therefore, it is urgent to probe practical prognostic indicator and therapeutic targets of OSCC.…”

Section: Introductionmentioning

confidence: 99%

LncRNA MEG3 suppresses migration and promotes apoptosis by sponging miR‐548d‐3p to modulate JAK–STAT pathway in oral squamous cell carcinoma

Tan

Xiang

2019

IUBMB Life

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Oral squamous cell carcinoma (OSCC) is a lethal malignancy and its prognosis remains dismal. Thus, a deeper understanding of the mechanisms is needed to provide a new insight for new therapies. It has been reported that long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) was downregulated in OSCC tissues, however, its functional mechanism remains uncertain. Here, we found that the overexpression of MEG3 suppressed migration and promoted apoptosis in OSCC cell lines, while inhibition of MEG3 exhibited opposite effect. We also found that MEG3 could effectively sponge miR‐548d‐3p and decrease its expression level. Moreover, miR‐548d‐3p repressed the expression of SOCS5 and SOCS6 through binding their 3’UTR, thereby modulating the JAK–STAT signaling pathway and functioning as an oncogene in OSCC cells. Importantly, overexpression of MEG3 enhanced the expression of SOCS5 and SOCS6 to regulate JAK–STAT pathway, whereas miR‐548d‐3p overexpression decreased the effects of MEG3 on levels of SOCS5/SOCS6. Furthermore, upregulated expression of miR‐548d‐3p could abrogate the effect of MEG3 overexpression on migration and apoptosis in OSCC cell lines. In addition, the overexpression of MEG3 inhibited tumor migration and facilitated apoptosis in vivo. Together, our results revealed that MEG3 could modulate JAK–STAT pathway via miR‐548d‐3p/SOCS5/SOCS6 to suppresses migration and promote apoptosis in OSCC. Our research indexed a new functional mechanism of MEG3 in OSCC, and this mechanism may be a potential prognostic factor and therapeutic target. © 2019 IUBMB Life, 2019

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Section: Introductionmentioning

confidence: 99%

LncRNA MEG3 suppresses migration and promotes apoptosis by sponging miR‐548d‐3p to modulate JAK–STAT pathway in oral squamous cell carcinoma

Tan

Xiang

2019

IUBMB Life

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“…‐45% of OSCC patients will develop local‐ or regional recurrence (LRR), a second primary tumor (SPT) or distant metastasis (DM) (further called second events) after primary curative‐intent treatment . Current guideline‐recommendations advocate follow‐up after curative treatment for all patients of at least 5 years . The main reason for follow‐up is the early detection of second events; other goals are functional rehabilitation and psychosocial support.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Current guideline-recommendations advocate follow-up after curative treatment for all patients of at least 5 years. 6 The main reason for follow-up is the early detection of second events; other goals are functional rehabilitation and psychosocial support.…”

Section: Introductionmentioning

confidence: 99%

Time patterns of recurrence and second primary tumors in a large cohort of patients treated for oral cavity cancer

et al. 2019

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Introduction Routine follow‐up after curative treatment of patients with oral squamous cell carcinoma (OSCC) is common practice considering the high risk of second primaries and recurrences (ie second events). Current guidelines advocate a follow‐up period of at least 5 years. The recommendations are not evidence‐based and benefits are unclear. This is even more so for follow‐up after a second event. To facilitate the development of an evidence‐ and personalized follow‐up program for OSCC, we investigated the course of time until the second and subsequent events and studied the risk factors related to these events. Materials and methods We retrospectively studied 594 OSCC patients treated with curative intent at the Head and Neck Cancer Unit of the Radboud University Medical Centre from 2000 to 2012. Risk of recurrence was calculated addressing death from intercurrent diseases as competing event. Results The 1‐, 5‐ and 10‐year cumulative risks of a second event were 17% (95% CI:14%;20%), 30% (95% CI:26%;33%), and 37% (95% CI:32%;41%). Almost all locoregional recurrences occurred in the first 2 years after treatment. The incidence of second primary tumors was relatively stable over the years. The time pattern of presentation of third events was similar. Discussion Our findings support a follow‐up time of 2 years after curative treatment for OSCC. Based on the risk of recurrence there is no indication for a different follow‐up protocol after first and second events. After 2 years, follow‐up should be tailored to the individual needs of patients for supportive care, and monitoring of late side‐effects of treatment.

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“…The usual follow-up strategy consists of periodic visual examination and palpation of the oral cavity during the 5-year aftercare period, including examination and palpation of other anatomical subsites of the head and neck region (nasopharynx, oropharynx, hypopharynx, and larynx) [4]. The main goal of a routine follow-up after OSCC is the early detection of recurrence or second primary tumors, together with monitoring functional rehabilitation, psychological support, and quality control [5]. In the case of recurrence, salvage surgery remains the only curative option [6].…”

Section: Introductionmentioning

confidence: 99%

13-gene DNA Methylation Analysis from Oral Brushing: A Promising Non Invasive Tool in the Follow-up of Oral Cancer Patients

Gissi

Tarsitano

Gabusi

et al. 2019

JCM

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Background: This study aimed to evaluate the prognostic value of a non-invasive sampling procedure based on 13-gene DNA methylation analysis in the follow-up of patients previously treated for oral squamous cell carcinoma (OSCC). Methods: The study population included 49 consecutive patients treated for OSCC. Oral brushing sample collection was performed at two different times: before any cancer treatment in the tumor mass and during patient follow-up almost 6 months after OSCC treatment, within the regenerative area after OSCC resection. Each sample was considered positive or negative in relation to a predefined cut-off value. Results: Before any cancer treatment, 47/49 specimens exceeded the score and were considered as positive. Six months after OSCC resection, 16/49 specimens also had positive scores in the samples collected from the regenerative area. During the follow-up period, 7/49 patients developed locoregional relapse: 6/7 patients had a positive score in the regenerative area after OSCC resection. The presence of a positive score after oral cancer treatment was the most powerful variable related to the appearance of locoregional relapse. Conclusion: 13-gene DNA methylation analysis by oral brushing may have a clinical application as a prognostic non-invasive tool in the follow-up of patients surgically treated for OSCC.

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Follow-up after curative treatment for oral squamous cell carcinoma. A critical appraisal of the guidelines and a review of the literature

Cited by 64 publications

References 69 publications

LncRNA MEG3 suppresses migration and promotes apoptosis by sponging miR‐548d‐3p to modulate JAK–STAT pathway in oral squamous cell carcinoma

LncRNA MEG3 suppresses migration and promotes apoptosis by sponging miR‐548d‐3p to modulate JAK–STAT pathway in oral squamous cell carcinoma

Time patterns of recurrence and second primary tumors in a large cohort of patients treated for oral cavity cancer

13-gene DNA Methylation Analysis from Oral Brushing: A Promising Non Invasive Tool in the Follow-up of Oral Cancer Patients

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