Background: Urinary diversion (UD) is the curative treatment for muscle-invasive bladder cancer. It is associated with significant functional and metabolic changes that may affect patients' perceived of quality of life. Aim: To Evaluate the effect of educational intervention and telephone follow-up program on knowledge, self-care performance and quality of life among patients undergoing urinary diversionDesign: A quasi-experimental research design was used. Setting: The study was conducted at the urological surgical departments and outpatient clinic at National Cancer Institute (NCI) between August, 2016 and September, 2017. Subjects: A purposive sample of 40 patients with UD, which divided randomly into two groups. Tools: Data were collected as following; socio-demographic and health history questionnaires, patients' urostomy knowledge questionnaire, patient's urostomy self-care performance checklist, and quality of life questionnaire to assess the QOL for UD.Results:most of the sample (85%) was male while (15%) was female in both groups undergo UD and Mean age was 55.6 years. There are highly statistically significant improved of knowledge and self-care performance in study group at the immediately and follow-up tests (p < 0.0001) after implementation of program compared by control group with routine care. Regarding to quality of life there was a significant differences between intervension group and controlled group at posttest and follow up (p<.0001). Conclusion:The study results emphasize the importance of the educational intervention for patients. UD patients showed significant improved in their knowledge, self-care practice and quality of life after participation of program at post and follow up test.Recommendations:Promoting educational, training and post discharge support in this population. Further studies and nurse training post discharge was considered as evidence to promote support and positive quality of life.