Follistatin-like 1 as a Novel Adipomyokine Related to Insulin Resistance and Physical Activity

Xu, Xiangdong; Zhang, Tingran; Mokou, Mani; Li, Ling; Li, Peng; Song, Jinlin; Liu, Hua; Zhu, Zhiming; Liu, Dongfang; Yang, Mengliu

doi:10.1210/clinem/dgaa629

Cited by 30 publications

(40 citation statements)

References 41 publications

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“…This result corroborates data obtained by human analysis that have shown how circulating FSTL-1 levels in obese and diabetic subjects were higher than in lean subjects. Moreover, Xu X et al have demonstrated that FSTL-1 protein expression increased dramatically in response to physical activity in healthy subjects [194]. These results confirm study performed by Kon et al that have proved that acute endurance exercise may stimulate the secretion of FSTL1 and apelin [195].…”

Section: Follistatin-like 1: Biological Rolesupporting

confidence: 70%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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: It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs and secrete in normal and in pathological conditions several molecules, called, respectively, adipokines, myokines, and cardiokines. These secretory proteins constitute a closed network that plays a crucial role in obesity and above all in cardiac diseases associated with obesity. In particular, the interaction between adipokines, myokines, and cardiokines is mainly involved in inflammatory and oxidative damage characterized obesity condition. Identifying new therapeutic agents or treatment having a positive action on the expression of these molecules could have a key positive effect on the management of obesity and its cardiac complications. Results from recent studies indicate that several nutritional interventions, including nutraceutical supplements, could represent new therapeutic agents on the adipo-myo-cardiokines network. This review focuses the biological action on the main adipokines, myokines and cardiokines involved in obesity and cardiovascular diseases and describe the principal nutraceutical approaches able to regulate leptin, adiponectin, apelin, irisin, natriuretic peptides, and follistatin-like 1 expression.

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Section: Follistatin-like 1: Biological Rolesupporting

confidence: 70%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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“…The physical examination included body weight, blood pressure (BP), waist circumference (WC), and body fat content (Fat %). Biochemical parameters included total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), free fatty acid (FFA), HbA1c, FBG, 2-hour postprandial blood glucose (2h-BG), fasting insulin (FIns), and 2-hour postprandial insulin (2h- INS), as previously reported ( Xu et al, 2020 ).…”

Section: Research Population and Methodsmentioning

confidence: 99%

Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide

Xue

Yang

et al. 2021

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Background and Aims Fetuin-B has been reported to be involved in glucose and lipid metabolism and associated with the occurrence of diabetes. The main purpose of this study is to explore the changes of circulating fetuin-B in young women with pre-diabetes and to analyze the relationship between fetuin-B and the occurrence and development of IR. Methods A total of 304 women were enrolled in this study and subjected to both OGTT and EHC. A subgroup of 26 overweight/obese womenwas treated with Lira for 24 weeks. serum fetuin-B concentrations were measured by ELISA. Results In IGT and IR-NG groups, serum fetuin-B levels were higher than those in the NGT group. The serum fetuin-B levels in the IGT group were higher than those in the IR-NG group. serum fetuin-B was positively correlated with BMI, WHR, 2h-BG, FIns, HbA1c, and HOMA2-IR, but negatively correlated with the M-value in all study populations. Multiple stepwise regression analysis showed that the M-value was independently and inversely associated with serum fetuin-B. Logistic regression analysis showed that serum fetuin-B was independently associated with IGT and significantly increased the risk of IGT. During the OGTT, serum fetuin-B increased significantly in the NGT group, but there were no significant changes in other groups. During the EHC, serum fetuin-B increased in the IGT group, but there was no change in other groups. After Lira intervention, serum fetuin-B decreased significantly in IGT women. Conclusions serum fetuin-B levels are elevated in young women with IR or IGT and may be associated with IR.

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“…Physical activity was found to significantly increase the circulating FSTL-1 concentration in young, healthy subjects. Likewise, FSTL-1 protein expression in AT rose dramatically in response to physical activity [ 42 ].…”

Section: Metabotrophic Factors As Therapeutic Targets In Drug Discoverymentioning

confidence: 99%

Cardio- and Neurometabolic Adipobiology: Consequences and Implications for Therapy

Fröhlich

Chaldakov

Vinciguerra

2021

IJMS

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Studies over the past 30 years have revealed that adipose tissue is the major endocrine and paracrine organ of the human body. Arguably, adiopobiology has taken its reasonable place in studying obesity and related cardiometabolic diseases (CMDs), including Alzheimer’s disease (AD), which is viewed herein as a neurometabolic disorder. The pathogenesis and therapy of these diseases are multiplex at basic, clinical and translational levels. Our present goal is to describe new developments in cardiometabolic and neurometabolic adipobiology. Accordingly, we focus on adipose- and/or skeletal muscle-derived signaling proteins (adipsin, adiponectin, nerve growth factor, brain-derived neuroptrophic factor, neurotrophin-3, irisin, sirtuins, Klotho, neprilysin, follistatin-like protein-1, meteorin-like (metrnl), as well as growth differentiation factor 11) as examples of metabotrophic factors (MTFs) implicated in the pathogenesis and therapy of obesity and related CMDs. We argue that these pathologies are MTF-deficient diseases. In 1993 the “vascular hypothesis of AD” was published and in the present review we propose the “vasculometabolic hypothesis of AD.” We discuss how MTFs could bridge CMDs and neurodegenerative diseases, such as AD. Greater insights on how to manage the MTF network would provide benefits to the quality of human life.

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Follistatin-like 1 as a Novel Adipomyokine Related to Insulin Resistance and Physical Activity

Cited by 30 publications

References 41 publications

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Association of serum fetuin-B with insulin resistance and pre-diabetes in young Chinese women: evidence from a cross-sectional study and effect of liraglutide

Cardio- and Neurometabolic Adipobiology: Consequences and Implications for Therapy

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