Folliculogenesis in the ovary of the mature mouse: A radioautographic study

Hoage, Terrell R.; Cameron, Ivan L.

doi:10.1002/ar.1091840409

Cited by 33 publications

(15 citation statements)

References 15 publications

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“…Atretic follicles were identified on the basis of the layer of pyknotic nuclei bordering the antrum, degenerative oocytes, and apoptosis detected by TUNEL (Hoage and Cameron 1976;Hakuno et al 1996). The types of follicles which appear in ovaries change with age (Peters 1969).…”

Section: Stagingmentioning

confidence: 99%

Syndecan-4 expression is associated with follicular atresia in mouse ovary

Ishiguro

Kojima

Taguchi

et al. 1999

Histochemistry and Cell Biology

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Ovarian granulosa cells synthesize heparan sulfate proteoglycans (HSPGs), that have anticoagulant properties. Moreover, HSPGs greatly increase in the granulosa cells during follicular atresia. However, the species of ovarian HSPGs have not yet been identified. Syndecan-4 (ryudocan, amphiglycan) is a membrane-spanning HSPG and a member of the syndecan family. Herein, we demonstrate that syndecan-4 is expressed in the granulosa cells of type 4-5b follicles and, most intensely, in those of the atretic follicles in the mouse ovary, as revealed by in situ hybridization. There is no relationship between syndecan-4 expression and age or sexual cycle stage. Compared with syndecan-4 expression, syndecan-1 and -3 are expressed more abundantly in postovulatory follicles and the corpora lutea, but less in the type 4-5b follicles and much less in the atretic follicles. Immunohistochemistry also demonstrates syndecan-4 expression in atretic follicles with apoptosis. The present study has revealed the distinct modes of expression of the syndecan family members, and the association of syndecan-4 expression and apoptosis in ovarian atretic follicles.

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Section: Stagingmentioning

confidence: 99%

Syndecan-4 expression is associated with follicular atresia in mouse ovary

Ishiguro

Kojima

Taguchi

et al. 1999

Histochemistry and Cell Biology

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“…Folliculogenesis requires oocyte-granulosa cell interaction, which is stabilised by extracellular matrix (ECM) components and, in its last two stages, depends also on hormones. Following activation, the primordial follicles undergo four successive stages of development, defined by oocyte growth and by the number and type of cells surrounding the oocyte ( Hoage and Cameron, 1976 ; reviewed by Pepling, 2006 ): accompanied by massive expansion of the granulosa cell layer, the primordial follicles give rise to (i) primary follicles which in turn progress to (ii) secondary follicles. Stimulated by gonadotropins (FSH and LH), further proliferation of the granulosa cells gives rise to the (iii) multi-layered antral follicle containing antral cavities ( Messinis et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility

Moll

Winkler

et al. 2015

Biology Open

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The postnatal mammalian ovary contains the primary follicles, each comprising an immature oocyte surrounded by a layer of somatic granulosa cells. Oocytes reach meiotic and developmental competence via folliculogenesis. During this process, the granulosa cells proliferate massively around the oocyte, form an extensive extracellular matrix (ECM) and differentiate into cumulus cells. As the ECM component hyaluronic acid (HA) is thought to form the backbone of the oocyte-granulosa cell complex, we deleted the relevant domain of the Receptor for HA Mediated Motility (RHAMM) gene in the mouse. This resulted in folliculogenesis defects and female hypofertility, although HA-induced signalling was not affected. We report that wild-type RHAMM localises at the mitotic spindle of granulosa cells, surrounding the oocyte. Deletion of the RHAMM C-terminus in vivo abolishes its spindle association, resulting in impaired spindle orientation in the dividing granulosa cells, folliculogenesis defects and subsequent female hypofertility. These data reveal the first identified physiological function for RHAMM, during oogenesis, and the importance of this spindle-associated function for female fertility.

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“…Unlike somatic cell and spermatocyte, mammalian growing stage oocyte has relatively larger nucleus, which is termed as germinal vesicle [18] and convenient for observing the dynamics of nucleoplasmic signals. The growth of mammalian oocytes would generally take several days or several months in a wave by wave manner depending on different species [19][20][21], so it is possible for us to collect different stage oocytes from adult ovaries. For female mouse, when their oocytes are fully grown, the oocyte transcription activities will be silenced and a Hoechst positive ring-like structure will be formed Surrounding the Nucleolus [22].…”

Section: Introductionmentioning

confidence: 99%

Cruciform DNA in mouse growing oocytes: Its dynamics and its relationship with DNA transcription

Xie¹,

F²,

Ou³

et al. 2020

PLoS ONE

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Cruciform DNA is a causing factor of genome instability and chromosomal translocation, however, most studies about cruciform DNA in mammalian cells were based on palindromic sequences containing plasmids and reports about endogenous cruciform DNA are rare. In this study we observed the dynamics of endogenous cruciform DNA in mouse growing oocytes using immunofluorescence labeling method. We found cruciform DNA foci exist in transcription active growing oocytes but not in transcription inactive fully grown oocytes and colocalized with Parp1 but not with DNA damage marker γH2A.X. By analyzing the Genotype-Tissue Expression data, we found cruciform DNA-mediated chromosomal translocation in human spermatocytes is associated with the specific DNA transcription in testis. When inhibiting the transcription with α-amanitin in mouse oocytes, we found oocyte cruciform DNA foci decreased significantly. In summary, we observed the endogenous cruciform DNA in growing oocytes and our results showed that the cruciform DNA formation is transcription-dependent.

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Folliculogenesis in the ovary of the mature mouse: A radioautographic study

Cited by 33 publications

References 15 publications

Syndecan-4 expression is associated with follicular atresia in mouse ovary

Syndecan-4 expression is associated with follicular atresia in mouse ovary

RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility

Cruciform DNA in mouse growing oocytes: Its dynamics and its relationship with DNA transcription

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