Folliculogenesis Disturbances within the Polycystic Ovarian Syndrome and Possible Consequences on Oocyte Quality

Surcel, Mihai

doi:10.4183/aeb.2012.267

Cited by 2 publications

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“…PCOS patients entering IVF procedures showed worse results compared to patients without ovarian pathology: an increased rate of immature oocytes, a reduced number of superior quality embryos (33, 34) and a decreased implantation rate (35). Oocyte quality is obviously indissolubly linked to the quality of follicle genesis.…”

Section: Discussionmentioning

confidence: 99%

The Follicular IGFBP Changes after Metformine Administration in Polycystic Ovary Syndrome and its Impact on the Fertility Rate. A randomized Study

Surcel¹

2014

Acta Endo (Buc)

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Background. Polycystic ovarian syndrome (PCOS) involves various changes within folliculogenesis. Aside from its systemic action, metformin seems to exert a local direct effect independent of insulinemia. The IGF system appears to be an important local target for metformin although the evidence we possess is circumstantial.Objective. The aim of this study was to evaluate the impact of metformin on insulin growth factor (IGF) system proteins and steroids production in PCOS patients and to analyze potential involvement in oocyte quality.Material and methods. This prospective study was performed on 86 in vitro fertilization (IVF) patients who were categorized into three groups as follows: Group 1 formed of PCOS patients who received metformin (n=27); Group 2 with PCOS patients who did not receive metformin (n=29) and Group 3 with controls (n=30).Interventions. Interventions included controlled ovarian stimulation for IVF and metformin (at least 16 weeks prior to the time of ovarian puncture).Main Outcome Measures.Follicular fluid analysis was performed using radioimmunoassay with specific kits (estradiol, testosterone, progesterone, IGF I, IGF II, IGF binding protein 1 -IGFBP1, IG-FBP2, IGFBP3, IGFBP4).Results. Important differences were measured for the three types of steroids among the three studied groups (PCOS treated, PCOS not treated, controls) estradiol (538 vs. 466 vs. 688 ng/mL p < 0.0001), testosterone (6.7 vs. 7.6 vs. 5.1 ng/mL p<0.01), progesterone (8899 vs. 7878 vs. 9755 pg/mL p<0.0001) while for IGF system proteins important differences were noted only regarding IGFBP1 (114 vs. 107 vs. 121 p<0.002) IGFBP2 (263 vs. 268 vs. 252 ng/mL p<0.04), and IGFBP4 (128 vs. 138 vs. 118 p<0001). Correlations were also established between fertilization rate and estradiol (R: 0.53 p<0.5), testosterone (R: -0.39 p<0.05), IGFBP1 (R: 0.48 p< 0.05), IGFBP4 (R: 0.39, p<0.05).Conclusions. Patients with PCOS and hyperinsulinemia have the greatest benefit from metformin treatment. However, metformin action surpasses correction of systemic differences having a direct action at the level of follicular structures. Alteration of IGF system proteins does not concern only hyperinsulinic patients and can be partially amended by metformin administration.

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Section: Discussionmentioning

confidence: 99%

The Follicular IGFBP Changes after Metformine Administration in Polycystic Ovary Syndrome and its Impact on the Fertility Rate. A randomized Study

Surcel¹

2014

Acta Endo (Buc)

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“…The persistence of acne in adulthood or its late onset (in women >25 years) suggests an endocrine cause due to hyperandrogenism ( 5 ). Although the most common cause of hyperandrogenism is represented by PCOS, the differential diagnoses with Cushing's syndrome, ovarian or adrenal androgen-secreting tumors, acromegaly or with non-endocrine disorders, Apert syndrome, Behçet's syndrome and SAHA syndrome (seborrhoea, acne, hirsutism and alopecia) are of importance ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Age-dependent endocrine disorders involved in the pathogenesis of refractory acne in women

Ianoși¹,

Ianoşi²,

Neagoe³

et al. 2016

Molecular Medicine Reports

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Acne is a disorder of the pilosebaceous unit, common among adolescents, which may be extended to adulthood. The aim of this study was to assess the prevalence of hormonal disorders in women with acne resistance to conventional therapy. We included 72 women aged between 15 and 36 years (divided in two age groups) who presented to our clinic between May and October 2014, suffering from moderate and severe forms of papulopustular and nodulocystic acne. The subjects were non-responsive to classic dermatological treatment or had clinical manifestation of hyperandrogenism. Based on age, we divided the women into two groups, group I with 40 patients aged 15–22years and group II with 32 patients aged 23–36 years. Using ELISA, a hormonal profile was performed for each patient in days 1–3 of the menstrual cycle including, total testosterone, dehydroepiandrosterone sulfate (DHEA-S), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, prolactin, and plasma cortisol. For statistical analysis we used Stata 13 software. We compared the hormonal profile of the two groups and identified significant differences for: testosterone levels (mean value, 0.64±0.35 vs. 0.97±0.50 ng/ml; p<0.0001), DHEA-S levels (mean value, 0.85±0.27 vs. 1.05±0.33 mg/24 h; p=0.001), prolactin levels (mean value, 281.85±91.113 vs. 353.969±102.841 mIU/ml; p=0.002) and LH levels (14.8±6.7 vs. 20.1±8.2 mIU/ml; p=0.002) were higher in group II. No statistically significant differences were found for estradiol (p=0.588) and cortisol (p=0.182) levels. In conclusion, refractory acne can be the first sign of systemic illness including polycystic ovary syndrome. Thus, for a correct therapeutic approach it is necessary to interpret the clinical and biochemical elements in correlation with the medical history.

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Folliculogenesis Disturbances within the Polycystic Ovarian Syndrome and Possible Consequences on Oocyte Quality

Cited by 2 publications

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The Follicular IGFBP Changes after Metformine Administration in Polycystic Ovary Syndrome and its Impact on the Fertility Rate. A randomized Study

The Follicular IGFBP Changes after Metformine Administration in Polycystic Ovary Syndrome and its Impact on the Fertility Rate. A randomized Study

Age-dependent endocrine disorders involved in the pathogenesis of refractory acne in women

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