Follicular thyroid carcinoma within a thyroglossal duct cyst in adult

Bifari, Ibtihaj Nasseraldeen; Alherabi, Ameen Z.; Alkaff, Haddad; Al-Arqen, Hamzeh; Jastania, Raid A

doi:10.5144/0256-4947.2018.305

Cited by 4 publications

(13 citation statements)

References 11 publications

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“…The origins of TDCC have not been established so far [3,4]. There are two theories regarding the start of thyroglossal duct cyst carcinoma [5,14]. One includes the presence of primary lesion in the thyroid gland and the development of metastases within the thyroglossal duct cyst wall [5,6].…”

Section: The Theories Of Tdcc Originmentioning

confidence: 99%

“…This theory has been supported by the fact that some TDCCs have been presented with a concurrent thyroid cancer. In addition, the fibrous tract that connects the TDCC and the thyroid gland is thought to be a possible path for the thyroid carcinoma to spread into the cyst [14].…”

Section: The Theories Of Tdcc Originmentioning

confidence: 99%

“…Based on the other theory, cancer arises de novo within the remnant of thyroglossal duct due to the thyroid ectopic tissue residue or from the epithelium of the cyst wall [5,6]. The lack of medullary carcinoma cases within the TDCs may support the thesis of de novo origin of TDCC rather than a metastatic theory [10,14].…”

Section: The Theories Of Tdcc Originmentioning

confidence: 99%

“…Unfortunately, only 53-66% of all FNAB results can detect carcinoma before surgery [3,7,16]. The false-negative diagnosis by FNAB is mostly because of small neoplasm size, marginal location of the tumor in the cyst or the hypocellularity that results from dilution due to the cystic content [14]. Therefore, it has been found to reserve FNAB only for investigation of suspicious findings favoring a diagnosis of malignancy, such as the presence of calcifications or solid components on ultrasound [3,7,16].…”

Section: The Diagnosis Of Tdccmentioning

confidence: 99%

“…Certain characteristics may suggest the presence of a cancer. On clinical examination, a rapid increase in size of the cyst, as well as firm fixture to the hyoid bone or surrounding structures and palpable mass may be indicative of carcinoma [2,5,14]. Malignancy should be also suspected if the regional lymph nodes are palpable [10,13,14].…”

Section: The Diagnosis Of Tdccmentioning

confidence: 99%

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Thyroglossal duct cyst papillary thyroid cancer – the state of the art

Dabrowska

Dudka

2021

Current Issues in Pharmacy and Medical Sciences

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Thyroglossal duct cyst is one of the most common congenital malformations in the neck area. The majority of cysts turn out to be benign tumors, however, 0.7-1.5 % of the remnants develop into carcinoma, with papillary thyroid cancer being the most frequent malignant neoplasm. The origin of the cancer has not been clearly established so far. Typically, thyroglossal duct cyst cancer is an enlarging flexible midline or slightly lateral neck mass, most often without other worrisome symptoms. The proper diagnosis can be difficult due to the rare prevalence of thyroglossal duct cyst papillary thyroid carcinoma, as well as a lack of strongly typical features distinguishing benign and malignant lesions before surgery. Thus, diagnosis is usually made postoperatively just after histopathological examination of a resected cyst. However, there are diagnostic procedures that should be considered before the surgery that may be helpful in making a proper diagnosis. These include fine-needle aspiration biopsy, computed tomography or magnetic resonance imaging. Moreover, there are some characteristics revealed through clinical and ultrasound examination that may suggest the presence of such cancer. While the Sistrunk procedure is often considered adequate, currently, there is no clear consensus about concurrent thyroidectomy or radioiodine therapy. In the article, we sum up the preoperative suggestive factors of cancer, as well as the proposed indications that can be helpful in deciding on the extent of surgery and further management.

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Section: The Theories Of Tdcc Originmentioning

confidence: 99%

Section: The Theories Of Tdcc Originmentioning

confidence: 99%

Section: The Theories Of Tdcc Originmentioning

confidence: 99%

Section: The Diagnosis Of Tdccmentioning

confidence: 99%

Section: The Diagnosis Of Tdccmentioning

confidence: 99%

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Thyroglossal duct cyst papillary thyroid cancer – the state of the art

Dabrowska

Dudka

2021

Current Issues in Pharmacy and Medical Sciences

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Clinical and cytopathological features of suspected thyroglossal duct cysts and neoplasms arising from them: A large series from a referral cancer center

Hou

Liu

Gan

et al. 2021

Cancer Cytopathology

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Background Thyroglossal duct cysts (TGDCs) are the most common congenital midline cystic lesions in the neck, and they are often evaluated by fine‐needle aspiration. Recognizing the cytomorphologic features of TGDCs and their mimics is important for clinical management. Methods This study examined the clinical, radiological, and cytopathological features of 86 ultrasonography‐guided fine‐needle aspiration (US‐FNA) specimens from clinically suspected TGDCs or malignancies arising from TGDCs and correlated the findings with surgical follow‐up and/or imaging studies. Results According to ultrasound examinations of 66 lesions, 17 (25.8%) were cystic, 8 (12.1%) were cystic with septations, 21 (31.8%) were cystic with solid nodules, and 20 (30.3%) were solid or cystic with internal debris. Cytopathologically, 81 lesions (94%) were categorized as benign, 2 (2%) were categorized as atypical, and 3 (3%) were categorized as malignant. In benign lesions, proteinaceous material (63%), histiocytes (63%), colloid (37%), squamous cells (35%), columnar cells (32%), follicular cells (15%), inflammatory cells (9%), and multinucleated giant cells (9%) were noted. Diagnoses in the benign category included TGDC in 64 patients (75%), TGDC or mimics (colloid nodule/epidermoid cyst) in 14 patients (17%), a colloid nodule in 1 patient, and thyroiditis in 1 patient. Surgical resection, performed in 23 patients, confirmed TGDCs in 12, benign mimics in 7, and carcinoma in 4. Conclusions Cytopathological features, in conjunction with imaging, allowed a definite diagnosis of TGDC in most patients (75%). The presence of mature squamous cells, thyroid follicular cells, with or without colloid and/or lymphocytes alone allowed a differential diagnosis of TGDC and its mimics in 17%. US‐FNA findings could not distinguish primary carcinomas arising from TGDCs from metastatic tumors.

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