Follicular thyroid carcinoma with metastasis to skin diagnosed by fine needle aspiration cytology

Agarwal, Shweta; Rao, Seema; Arya, Anupama; Gupta, Kusum; Arora, Rashmi; Dhawan, Indrani

doi:10.4103/0377-4929.42552

Cited by 19 publications

(15 citation statements)

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“…[15] Face, neck, chest, arm and pelvis are the other cutaneous sites of metastasis affected with scalp. [16][17][18][19] Eighteen cases of FTC metastasis to scalp were reported in the literature [3,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] (Table 1). Two cases reported by Lissak et al [20] were follicular microcarcinoma revealed by solitary scalp lesions.…”

Section: Follicular Carcinomamentioning

confidence: 99%

Scalp metastases from thyroid carcinomas: review of clinical and pathological features

Arslan¹

2014

J Med Updates

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Thyroid carcinoma represents 1% to 1.5% of all cancer cases reported annualy and accounts for 57% of all deaths caused by endocrine malignancies. [1] Well-differentiated thyroid carcinomas including papillary and follicular carcinoma are the most common thyroid malignancies comprising approximately 70% and 10% respectively, of all cases. Scalp as a distinct cutaneous area has a rich dermal vasculature and is a site of various primary and metastatic neoplasms. Different visceral malignancies such as cancers of lung, breast, thyroid, colon, kidney, adrenal glands and larynx can metastasize to scalp. Metastases to scalp from thyroid carcinomas are extremely rare and demonstrate advanced disease and poor prognosis. Such lesions may indicate treatment failure or alternatively they may be the ÖzetBu derlemede literatürde skalp metastaz› yapt›¤› bildirilen tiroid karsinom vakalar› taranarak tan›sal, histopatolojik ve prognostik özellik-leri ile tart›fl›ld›. PubMed ve MedLine servislerinde yay›nlanan tüm tiroid karsinomlar›na ba¤l› skalp metastaz› vakalar› araflt›r›ld› ve hastalar›n yafl ve cinsiyetine, tiroid karsinomunun histolojik tipine, skalp d›fl›nda cilt alanlar›na metastazlar›na ve primer tümörün teflhisiyle metastaz teflhisi aras›ndaki süreye iliflkin verilere ulaflmak için hasta bilgileri incelendi. Literatürde günümüze kadar bildirilen 38 vaka bulundu. Bildirilen vakalarda en s›k görülen histolojik tip foliküler karsinom (%46) idi. Papiller karsinom, medüller karsinom ve anaplastik karsinom vakalar›n›n oranlar› ise s›ras›yla %35, %16 ve %3 olarak bulundu. Özel bir cilt alan› olan skalp zengin bir damar a¤›na ve kanlanmaya sahip olup çeflitli primer veya metastatik tümörlerin oda¤› olabilir. Tiroid karsinomlar›na ba¤l› skalp metastazlar› oldukça nadir olup ilerlemifl hastal›¤a ve kötü prognoza iflaret eder. Düflük metastatik potansiyele sahip gizli bir neoplazm›n ilk belirtisi olarak ç›kabilen bir skalp nodülünün teflhisi oldukça güç olabilir. Tiroid karsinomlar›-n›n histopatolojik özelliklerinin ve cilt metastaz› kal›plar›n›n bilinmesiyle bu gibi lezyonlar›n tan›s›na daha kolay ulafl›labilir.Anahtar sözcükler: Metastaz, skalp, tiroid karsinomu. AbstractThyroid carcinomas reported to metastasize to scalp were reviewed and discussed with histopathological, prognostic and diagnostic aspects. All cases of scalp metastasis from thyroid carcinomas published in PubMed and MedLine were reviewed and the data of all patients were analyzed to obtain information about the patient demographics, histologic type of thyroid carcinoma, additional cutaneous sites, time interval between the diagnosis of the primary tumor and the diagnosis of scalp metastasis. The literature review revealed 38 cases of scalp metastasis from thyroid carcinoma. The most common histologic type was follicular carcinoma (46%), followed by papillary (35%), medullary (16%) and anaplastic carcinomas (3%). Scalp as a distinct cutaneous area has a rich dermal vasculature and is a site of various primary and metastatic neoplasms. Metastases to scalp from ...

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Section: Follicular Carcinomamentioning

confidence: 99%

Scalp metastases from thyroid carcinomas: review of clinical and pathological features

Arslan¹

2014

J Med Updates

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“…There was an unusual case of Hurthle cell carcinoma of the thyroid with cutaneous metastases to the right chest wall. Cutaneous metastases of thyroid carcinoma are infrequent [12,13,14] and FNA is an important method for rapid diagnosis of such lesions [12].There have been fewer than 30 case reports of cutaneous metastases of thyroid carcinoma in the literature with majority to head and neck. [12] Cutaneous malignancies are less commonly in malignancies such as leukemia and lymphoma .3 cases of secondary NHL skin were seen in our study.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Metastatic Cutaneous Lesions on Fine Needle Aspiration Cytology: A Five Year Study

Yasin¹,

Bashir²,

Khan³

2017

AABS

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Background: Cutaneous and subcutaneous metastatic deposits are rare and can be seen in 0.8-5% cases. This study was done to evaluate the role of Fine Needle Aspiration Cytology(FNAC) in the diagnosis of cutaneous and subcutaneous nodules in patients with known malignancy or as a primary manifestation of an unknown malignancy. Methods:It was a 5 year retrospective study and the record of patients subjected to FNAC during this period was reviewed.Results: Out of total number of 13572 patients 58(0.42%) were diagnosed as cutaneous /subcutaneous metastatic deposits .In 51 cases ,the primary was known and in 7 cases it was an initial manifestation of an unknown primary. There were 39 males and 19 females with age range of 27-82 years .Conclusion: Commonest site of metastases was chest wall and most common primary was lung. Adenocarcinoma was the commonest diagnosis on morphology. This study emphasizes the efficacy of FNAC on the accurate diagnosis of subcutaneous nodules especially in patients with known malignancy .It also offers clue to the underlying malignancy in occult primary.

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“…[13][14][15][16][17][18] Overall, females outnumber males (12:6); the mean age at presentation is about 65 (41-85), with locations of the skin metastases being the scalp (13 pts), neck (3 pts), face (2 pts) and others (2 pts). [13][14][15][16][17][18] Clinically, they mostly present as asymptomatic skin-colored or red, angioma-like, firm and mobile dermal and subcutaneous papules and nodules that range in size from a few millimeters to several centimeters in diameter and that can occasionally erode and ulcerate both superficially and deeply, into the bone. 19 A vascular appearance has indeed been identified in these lesions, to the point of even showing a pulsatile character upon Doppler echography.…”

Section: Discussionmentioning

confidence: 99%

“…Fine needle aspiration cytology has also been successfully used in this context. 15 With regard to plain HE histological sections, in a nodular dermally located lesion with an epithelial phenotype, several other diagnoses should be ruled out, including adnexal skin tumors, metastatic prostate, bronchopulmonary and gastrointestinal adenocarcinoma. In our patient`s case, the known existence of a widely metastatic follicular thyroid carcinoma led us to value it as the probable primary tumor.…”

Section: Discussionmentioning

confidence: 99%

Metástases Cutâneas de Carcinoma de Células de Hürthle da Tiróide

Tavares‐Bello¹,

Tavares-Bello²,

Fernandes³

et al. 2017

SPDV

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RESUMO -Metástases cutâneas de neoplasias internas constituem um evento raro, ocorrendo em 0,9% a 4,4% em grandes estudos necrópsicos e atingindo 9% em grandes séries de doentes neoplásicos. Metástases cutâneas de carcinomas da tiróide são ainda mais raros e, entre eles, os de carcinomas foliculares foram mais raramente reportados, mais escassamente do que os de carcinomas papilares ou medulares. Um Eurocaucasiano de 57 A de idade recorreu à consulta por pápula angiomatoide na área parietal do couro cabeludo, com cerca de 4 meses de evolução. O doente tinha sido submetido, 2 anos antes, a tiroidectomia total, complementada com radioterapia e diversos esquemas quimioterapêuticos por um carcinoma metastático de células de Hürthle da tiróide. A biópsia excisional da pápula permitiu estabelecer, com recurso a estudos imuno-histoquímicos, o diagnóstico de metástase cutânea de carcinoma folicular da tiróide. Os gânglios linfáticos, pulmões e os ossos constituem as mais prevalentes localizações à distância das metástases do carcinoma folicular da tiróide. Embora estas neoplasias representem até 12% das neoplasias malignas da tiróide, metástases cutâneas destes tumores têm sido muito raramente reportadas. Estes tumores são habitualmente carcinomas bem diferenciados, com prognóstico favorável a longo termo e caracterizados histologicamente por estruturas foliculares com material colóide e variáveis anaplasia e distorção arquitectural. No caso apresentado merecem destaque a morfologia angiomatoide da lesão metastática, classicamente associada a metástases de tumores de células renais e a alguns casos já relatados de tumores de células de Hürthle, bem como o comportamento agressivo e a evolução fatal verificados. O caso é ilustrado iconograficamente e uma breve revisão da literatura é efectuada. PALAVRAS-CHAVE -

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Follicular thyroid carcinoma with metastasis to skin diagnosed by fine needle aspiration cytology

Cited by 19 publications

References 0 publications

Scalp metastases from thyroid carcinomas: review of clinical and pathological features

Scalp metastases from thyroid carcinomas: review of clinical and pathological features

Evaluation of Metastatic Cutaneous Lesions on Fine Needle Aspiration Cytology: A Five Year Study

Metástases Cutâneas de Carcinoma de Células de Hürthle da Tiróide

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