Follicular spicules of the nose: A peculiar cutaneous manifestation of multiple myeloma with cryoglobulinemia

Follicular hyperkeratosis as a manifestation of Sézary syndrome

“…In both our patients marked follicular hyperkeratosis started on the face giving the appearance of spinulosis. This form of marked spinulosis, particularly on the nose, has been reported in patients with multiple myeloma as discussed, and also in cryoglobulinaemia, 7 neither of which were present in our patients. An idiopathic form of spinulosis has also been reported 8 .…”

Multiple minute digitate hyperkeratosis: A proposed algorithm for the digitate keratoses

“…Treatments have not been reported in the literature. We favor the term ''postirradiation digitate keratosis'' over the synonymous terms presented in Table I, as this was the term first used when described by Burns 35 in 1986. Hyperkeratotic spicules [39][40][41][42][43][44][45][46][47] are follicular or nonfollicular digitate keratoses of the face (nose in particular), and may also involve the scalp, trunk, and limbs. They are often associated with paraproteinemia, multiple myeloma, and cryoglobulinemia, but may be idiopathic.…”

Diseases of cutaneous appendages

“…[1295][1296][1297] The spicules are composed of eosinophilic, compact, homogeneous material which is largely the monoclonal protein of the underlying gammopathy. [1295][1296][1297] The spicules are composed of eosinophilic, compact, homogeneous material which is largely the monoclonal protein of the underlying gammopathy.…”