Follicular origins of modern reproductive endocrinology

Stephens, Sahar M.; Moley, Kelle H.

doi:10.1152/ajpendo.00575.2009

Cited by 10 publications

(7 citation statements)

References 12 publications

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“…Although mean volumes were reduced at other doses, due to the variation in the tumor weights, the values of the mean tumor weights were not significantly different from control. Since the mouse uterus is extremely sensitive to estrogen stimulation, changes in uterine weight are useful in monitoring estrogen effects in vivo (16-18). As previously shown, AIs block estrogen production and reduce uterine weight (19-23).…”

Section: Resultsmentioning

confidence: 99%

Functional Activation of the Estrogen Receptor-α and Aromatase by the HDAC Inhibitor Entinostat Sensitizes ER-Negative Tumors to Letrozole

et al. 2011

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Approximately 25% of breast cancers do not express the estrogen receptor-a (ERa) and consequently do not respond to endocrine therapy. In these tumors, ERa repression is often due to epigenetic modifications such as methylation and histone deacetylation. For this reason, we investigated the ability of the histone deacetylase inhibitor entinostat (ENT) to trigger reexpression of ERa and aromatase in breast cancer cells, with the notion that this treatment would restore sensitivity to the aromatase inhibitor (AI) letrozole. ENT treatment of tumor cells increased expression of ERa and aromatase, along with the enzymatic activity of aromatase, in a dosedependent manner both in vitro and in vivo. Notably, ERa and aromatase upregulation resulted in sensitization of breast cancer cells to estrogen and letrozole. Tumor growth rate was significantly lower in tumor xenografts following treatment with ENT alone and in combination with letrozole than in control tumors (P > 0.001). ENT plus letrozole also prevented lung colonization and growth of tumor cells, with a significant reduction (P > 0.03) in both visible and microscopic foci. Our results show that ENT treatment can be used to restore the letrozole responsiveness of ER-negative tumors. More generally, they provide a strong rationale for immediate clinical evaluation of combinations of histone deacetylase and aromatase inhibitors to treat ER-negative and endocrineresistant breast cancers. Cancer Res; 71(5); 1893-903. Ó2011 AACR.

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Section: Resultsmentioning

confidence: 99%

Functional Activation of the Estrogen Receptor-α and Aromatase by the HDAC Inhibitor Entinostat Sensitizes ER-Negative Tumors to Letrozole

et al. 2011

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“…A major advance in the field of reproductive endocrinology, initially based upon anatomical and histological evidence, was the proven theory that menstruation was under the regulation of an ovary-derived hormone [ 52 ]. The work by Edgar Allen and Edward Doisy published in 1923 [ 53 ] challenged the current hypothesis at the time, which had the corpus luteum (CL) as the source of the ovarian endocrine factor.…”

Section: Ovarian Sex Steroids and Their Receptorsmentioning

confidence: 99%

Sex Steroid-Mediated Control of Oviductal Function in Cattle

Binelli

Gonella-Diaza

Mesquita

et al. 2018

Biology

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In cattle, the oviduct is a tubular organ that connects the ovary and the uterus. The oviduct lumen stages a dynamic set of cellular and molecular interactions to fulfill the noble role of generating a new individual. Specific anatomical niches along the oviduct lumen provide the appropriate microenvironment for final sperm capacitation, oocyte capture and fertilization, and early embryo development and transport. To accomplish such complex tasks, the oviduct undergoes spatially and temporally-regulated morphological, biochemical, and physiological changes that are associated with endocrine events of the estrous cycle. Specifically, elevated periovulatory concentrations of estradiol (E2) and progesterone (P4) influence gene expression and morphological changes that have been associated positively to fertility in beef cattle. In this review, we explore how E2 and P4 influence oviductal function in the beginning of the estrous cycle, and prepare the oviductal lumen for interactions with gametes and embryos.

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“…However, using marker assisted selection (MAS) can speed up genetic improvements in litter size traits [ 3 ]. As the ovary directly mediates ovulation, it has a significant impact on the fecundity of mammals, and therefore, genetic differences in the ovaries may contribute to the observed differences in litter size [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Analysis of Ovaries from Pigs with High And Low Litter Size

Zhang

Huang

et al. 2015

PLoS ONE

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Litter size is one of the most important economic traits for pig production as it is directly related to the production efficiency. Litter size is affected by interactions between multiple genes and the environment. While recent studies have identified some genes associated with prolificacy in pigs, transcriptomic studies of specific genes affecting litter size in porcine ovaries are rare. In order to identify candidate genes associated with litter size in swine, we assessed gene expression differences between the ovaries of Yorkshire pigs with extremely high and low litter sizes using the RNA-Seq method. A total of 1 243 differentially expressed genes were identified: 897 genes were upregulated and 346 genes were downregulated in high litter size ovary samples compared with low litter size ovary samples. A large number of these genes related to steroid hormone regulation in animal ovaries, including 59 Gene Ontology terms and 27 Kyoto Encyclopedia of Genes and Genomes pathways involved in steroid biosynthesis and ovarian steroidogenesis. From these differentially expressed genes, we identified a total of 11 genes using a bioinformatics screen that may be associated with high litter size in Yorkshire pigs. These results provide a list of new candidate genes for porcine litter size and prolificacy to be further investigated.

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Follicular origins of modern reproductive endocrinology

Abstract: This essay looks at the historical significance of the APS Classic Paper: Allen E, Doisy EA. The induction of a sexually mature condition in immature females by injection of the ovarian follicular hormone.

Cited by 10 publications

References 12 publications

Functional Activation of the Estrogen Receptor-α and Aromatase by the HDAC Inhibitor Entinostat Sensitizes ER-Negative Tumors to Letrozole

Functional Activation of the Estrogen Receptor-α and Aromatase by the HDAC Inhibitor Entinostat Sensitizes ER-Negative Tumors to Letrozole

Sex Steroid-Mediated Control of Oviductal Function in Cattle

Transcriptomic Analysis of Ovaries from Pigs with High And Low Litter Size

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