Follicular lymphoma with deposits of amorphous hyaline material

Talerman, Aleksander; Platenburg, H. P. J. M.

doi:10.1002/path.1711120106

Cited by 8 publications

(3 citation statements)

References 12 publications

(4 reference statements)

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“…In cellular areas, a fine fibrillar staining pattern was regularly observed around and between individual cells, aggregating focally into coarse, amorphous deposits. These apparently corresponded to the amorphous, eosinophilic intercellular material that has been described in routine histologic sections of Hodgkin's disease and other lymphomas (62,63). Similar appearing material, shown to represent fibrin, had previously been described in germinal centers of reactive follicles from hyperplastic lymph nodes (64), a finding we confirmed (29).…”

Section: Benign Breast Lesions (61)supporting

confidence: 77%

Fibrin as a component of the tumor stroma: origins and biological significance

1983

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An association between cancer and the coagulation system was suggested by Trousseau more than a century ago and initial reports of fibrin deposition in the stroma of solid tumors date back some 25 years. However, the validity and generality of these observations have only quite recently been established, and their implications for an understanding of tumor biology, metastasis, and therapy are only now coming to be appreciated by investigators in the mainstream of cancer research. This article reviews the current status of fibrin's role in the biology of tumor growth, considering in turn: (1) the evidence that fibrin is present in tumors, the nature of such fibrin, and its relation to plasma fibronectin; (2) the mechanisms by which fibrin may come to be deposited in tumors; and (3) the potential biological and medical significance of tumorassociated fibrin deposition and degradation. Among the last are such important possibilities as a barrier function to the immune response and possible roles in angiogenesis, desmoplasia, and metastasis.

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Section: Benign Breast Lesions (61)supporting

confidence: 77%

Fibrin as a component of the tumor stroma: origins and biological significance

1983

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“…Similar PAS-positive non-amyloid proteinaceous material was noted in several cases of follicular and Hodgkin lymphomas. [7][8][9][10][11] However, in the reported cases of deposits in follicular lymphoma by Rosas-Uribe et al, this nonamyloid extracellular material was present in smaller quantities. 7 In one instance, frozen section was reported to express the same membranous antigens as the malignant lymphoma cells and likely represents clonal immunoglobulin deposits.…”

Section: Discussionmentioning

confidence: 99%

Proteinaceous Lymphadenopathy in a Young Patient With History of Classical Hodgkin Lymphoma: A Case Report With Literature Review

2018

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Proteinaceous lymphadenopathy (PLD) is a poorly defined, underreported pathological entity of uncertain etiology characterized by massive deposition of amorphous, eosinophilic, and periodic acid-Schiff-positive material involving lymph nodes, which is distinct from amyloid and clonal immunoglobulin deposition. PLD can resemble collagen sclerosis and needs to be differentiated from lymphomas with sclerosis, particularly classical Hodgkin lymphoma, nodular sclerosis type, and therefore is an important pitfall in the diagnosis of lymphoma with sclerosis. We are reporting a young patient with history of classical Hodgkin lymphoma who eventually developed PLD and review the literature on this subject.

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“…Ultrastructural studies confirmed that this material is not collagen, but rather accumulated membranous structures. These deposits must be differentiated from amyloid and stromal reactions described as hyalinosis, fibrosis, and orsclerosis 35 , 48 , 49 . Furthermore, since proteinaceous precipitates are often present within hyperplastic lymphoid follicles, a misdiagnosis of RFH could be made.…”

Section: Fl With Abundant Eosinophilic Precipitatementioning

confidence: 99%

The broad landscape of follicular lymphoma: Part I

Fratoni

2020

Pathologica

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Summary Follicular lymphoma is a neoplasm derived from follicle center B cells, typically both centrocytes and centroblasts, in variable proportions according to the lymphoma grading. The pattern of growth may be entirely follicular, follicular and diffuse, and rarely completely diffuse. It represents the second most common non-Hodgkin lymphoma, after diffuse large B-cell lymphoma and is the most common low-grade mature B-cell lymphoma in western countries. In the majority of cases, follicular lymphoma is a nodal tumor, occurring in adults and frequently associated with the translocation t(14;18)(q32;q21)/IGH-BCL2. However, in recent years the spectrum of follicular lymphoma has expanded and small subsets of follicular lymphoma, which differ from common follicular lymphoma, have been identified and included in the current 2017 WHO classification. The aim of our review is to describe the broad spectrum of follicular lymphoma, pointing out that the identification of distinct clinicopathological variants of follicular lymphoma is relevant for patient outcomes and choice of treatment.

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Follicular lymphoma with deposits of amorphous hyaline material

Cited by 8 publications

References 12 publications

Fibrin as a component of the tumor stroma: origins and biological significance

Fibrin as a component of the tumor stroma: origins and biological significance

Proteinaceous Lymphadenopathy in a Young Patient With History of Classical Hodgkin Lymphoma: A Case Report With Literature Review

The broad landscape of follicular lymphoma: Part I

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