Follicular lipidosis in a dachshund dog

Colodel, Marcia Moleta; Pietroluongo, Bruno; Lucas, Ronaldo; Gomes, Kenia B.; Grandi, Fabrizio

doi:10.1111/vde.12424

Cited by 1 publication

(2 citation statements)

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“…Melatonin may be a potential treatment for androgenetic alopecia ( 12 ). Rats ( 3 ), mice ( 4 ), guinea pigs ( 5 ), rabbits ( 6 ), and dogs ( 7 ) are animal models for studying human hair follicles. Comparative studies on the impact of diacylglycerol O-acyltransferase 1 (DGAT1) on mouse and dog alopecia suggest that mice may be an especially sensitive species ( 41 ).…”

Section: Discussionmentioning

confidence: 99%

“…Alopecia (hair loss) due to endocrine disorders has always plagued humans ( 1 , 2 ). Animal models for studying hair follicles in humans are usually rats ( 3 ), mice ( 4 ), guinea pigs ( 5 ), rabbits ( 6 ), and dogs ( 7 ). In addition, the goat PLP2 ( proteolipid protein 2 ) gene expressed only in the inner root sheath, suggesting that it may be associated with alopecia ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

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Melatonin’s effect on hair follicles in a goat (Capra hircus) animal model

Rong,

Ma,

Zhang

et al. 2024

Front. Endocrinol.

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IntroductionMelatonin can treat androgenetic alopecia in males. Goats can be used as animal models to study melatonin treatment for human alopecia. In this study, a meta-analysis of melatonin’s effects on goat hair follicles was pursued.MethodsLiterature from the last 20 years was searched in Scopus, Science Direct, Web of Science and PubMed. Melatonin’s effect on goat hair follicles and litter size were performed through a traditional meta-analysis and trial sequential analysis. A network meta-analysis used data from oocyte development to blastocyst. The hair follicle genes regulated by melatonin performed KEGG and PPI. We hypothesized that there are differences in melatonin receptors between different goats, and therefore completed melatonin receptor 1A homology modelling and molecular docking.ResultsThe results showed that melatonin did not affect goat primary follicle or litter size. However, there was a positive correlation with secondary follicle growth. The goat melatonin receptor 1A SNPs influence melatonin’s functioning. The wild type gene defect MR1 is a very valuable animal model.DiscussionFuture studies should focus on the relationship between goat SNPs and the effect of embedded melatonin. This study will provide theoretical guidance for the cashmere industry and will be informative for human alopecia research.

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