Follicular Hyperplasia, Follicular Lysis, and Progressive Transformation of Germinal Centers

Chang, Chung‐Che; Osipov, Vladimir; Wheaton, Sue; Tripp, Sheryl R.; Perkins, Sherrie L.

doi:10.1309/uueplf2phyxqdjnq

Cited by 43 publications

(25 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the theories about the cause of that inward migration is believed to be due to the redistribution of the germinal center T cells and the loss of their preferential location near the FDCs in the light zone, which likely induces subsequent B-cell migration [25]. Although PTGC has been linked to nodular lymphocyte predominant Hodgkin lymphoma in a small subset of the cases, it is more commonly seen in association with reactive follicular hyperplasia representing part of the spectrum of the reactive changes, where it has been reported that up to 10% of reactive nodes with nonspecific lymphadenitis contain one or more areas of PTGC [26]. At the early stages of PTGC process, the FDC Fig.…”

Section: Fdcs In Progressive Transformation Of Germinal Centers and Fmentioning

confidence: 99%

Follicular dendritic cells: origin, function, and different disease-associated patterns

et al. 2013

View full text Add to dashboard Cite

Summary Follicular dendritic cells (FDCs) are a specialized type of antigen-presenting dendritic cells that are largely restricted to lymphoid follicles. They form dense three-dimensional meshwork patterns within benign follicles, which maintain the follicular architecture. The FDC function is to bind and retain antigens by linking to complement and immune complexes and then present these antigens to germinal center B cells that start the secondary immune response. FDCs aid in the rescue of bound B cells from apoptosis, and induce the differentiation of B cells into long-term memory B cell clones or plasma cells. We will discuss the different patterns of the FDC meshwork observed in different types of reactive and neoplastic disorders, which may be due to underlying different roles that FDCs may play in these disorders and whether changes in the architecture of the FDC meshwork can be useful in routine diagnostic practice or have a prognostic value.

show abstract

Section: Fdcs In Progressive Transformation Of Germinal Centers and Fmentioning

confidence: 99%

Follicular dendritic cells: origin, function, and different disease-associated patterns

et al. 2013

View full text Add to dashboard Cite

show abstract

“…It typically affects focal areas within reactive lymph nodes, although a "florid" form involving multiple sites within individual lymph nodes and/or multiple lymph nodes has been described afflicting young men [62]. Histologically PTGC is characterized by lymph nodes with large, well-defined nodules containing an excess of B cells [63,64]. Some studies have reported 10%-30% of PTGC patients with antecedent, concurrent, or subsequent HL, particularly NLPHL [65,66], while others have not demonstrated such a correlation [62].…”

Section: Differential Diagnosis Of Nlphl and Associated Disorders Promentioning

confidence: 99%

Nodular Lymphocyte Predominant Hodgkin Lymphoma

Lee

LaCasce

2009

The Oncologist

View full text Add to dashboard Cite

show abstract

“…(iii) Progressive transformation of GC (PTGC). 8,10,11 The PTGC appeared as a A relatively large number of residual centrocytes, centroblasts and immunoblasts were present, in addition to small mantle zone lymphocytes. HE, x100 (Case 3).…”

Section: Pathological Findingsmentioning

confidence: 99%

“…1c). 8,10,11 (iv) Large nodules of mantle cells contained multiple small atrophic GC with increased vascularity (multiple GC pattern) (Fig. 1d).…”

Section: Pathological Findingsmentioning

confidence: 99%

See 1 more Smart Citation

“Follicular Variant” of Hyaline-vascular Type of Castleman's Disease : Histopathological and Immunohistochemical Study of 11 Cases

Kojima

Shimizu

Ikota

et al. 2008

J Clin Exp Hematopathol

View full text Add to dashboard Cite

Occasionally, the hyaline-vascular type of Castleman's disease (HVCD) contains numerous lymphoid follicles which usually occupy more than 50% of the lesion. Such lesions are called the follicular variant (FV) of HVCD. To clarify the histological and immunohistochemical findings of lymphoid follicles in the FV of HVCD, we examined 11 such cases. Histologically, five types of lymphoid follicles were delineated. Lymphoid follicles ; (i) with normal germinal centers (GCs) ; (ii) showing follicular lysis ; (iii) with progressive transformation of GC (PTGC) ; (iv) where the large nodule of mantle zone lymphocytes contained multiple small atrophic GCs (multiple GC pattern) ; and (v) where the large, often irregularly shaped nodules of mantle cells radically penetrated small vessels with inconspicuous GCs. These nodules somewhat resembled primary lymphoid follicles (primary follicular pattern). The majority of lymphoid follicles in all 11 cases were of the primary follicular pattern and/or multiple GC pattern. However, three lesions also contained normal germinal GC, while two contained normal GC, follicular lysis and PTGC and one other contained normal GC and PTGC. Moreover, in 3 cases of primary follicular pattern, the majority of the lymphoid follicles were surrounded by a pale cuff of mantle cells. Because of the presence of numerous lymphoid follicles, the FV of HVCD should be sometimes differentiated from Hodgkin lymphoma and low-grade B-cell lymphomas showing follicular growth pattern. Recognition of the histological and immunohistochemical findings of the FV of HVCD is needed to avoid overdiagnosis. 〔J Clin Exp Hematopathol 48(2) : 39-45, 2008〕

show abstract

Follicular Hyperplasia, Follicular Lysis, and Progressive Transformation of Germinal Centers

Cited by 43 publications

References 0 publications

Follicular dendritic cells: origin, function, and different disease-associated patterns

Follicular dendritic cells: origin, function, and different disease-associated patterns

Nodular Lymphocyte Predominant Hodgkin Lymphoma

“Follicular Variant” of Hyaline-vascular Type of Castleman's Disease : Histopathological and Immunohistochemical Study of 11 Cases

Contact Info

Product

Resources

About