Follicular Function in the Domestic Cat as Determined by Estradiol-17β Concentrations in Plasma: Relation to Estrous Behavior and Cornification of Exfoliated Vaginal Epithelium

Shille, V. M.; Lundström, Kerstin; Stabenfeldt, G. H.

doi:10.1095/biolreprod21.4.953

Cited by 136 publications

(82 citation statements)

References 20 publications

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“…The samples were sent to the Endocrinology Laboratory of the School of Veterinary Medicine at the University of California at Davis for analysis of estradiol concentration by using a charcoal-based, tritium-labeled radioimmunoassay. 33 The mean plasma estradiol level 4 to 6 weeks after ovariectomy was 11.2Ϯ1.4 pg/mL.…”

Section: Plasma Estradiol Measurementsmentioning

confidence: 91%

Modified LDL–Mediated Increases in Endothelial Layer Permeability Are Attenuated With 17β-Estradiol

Gardner

Banka

Roberts

et al. 1999

ATVB

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Abstract-Current research suggests that estrogen may have primary effects on the artery wall. To investigate the mechanisms of female sex hormone actions in the artery wall, we used an isolated, perfused, rat carotid artery model to examine the effects of estradiol on the rates of accumulation of normal (N-LDL) and minimally modified (MM-LDL) low density lipoprotein in ovariectomized rats. N-LDL, MM-LDL, and oxidized LDL (OX-LDL) were fluorescently labeled and perfused into individual arteries. The rate of LDL accumulation was measured by quantitative fluorescence microscopy before and after treatment with estradiol (1 nmol/L, 272 pg/mL). Estradiol had no effect on the rate of Key Words: artery Ⅲ arteriosclerosis Ⅲ LDL Ⅲ estrogen Ⅲ oxidized LDL Ⅲ endothelium Ⅲ permeability A cardinal characteristic of the development of atherosclerosis is the accumulation of LDL within the arterial wall. 1-3 Sites of relative increase in LDL permeability have been identified in normal arteries 4 and can be induced by injury to the endothelium. 5-9 Alternatively, others have reported increased binding and decreased efflux of LDL from the vascular wall, even under conditions where LDL influx was not affected. 10,11 Therefore, LDL accumulation in the artery wall potentially occurs by several mechanisms, perhaps depending on the stage of atheroma formation.A large body of evidence indicates that modification of LDL in the artery wall promotes atherosclerosis. 12 Recent studies demonstrate evidence of modification of LDL in the blood. [13][14][15][16][17] Furthermore, a previous study showed increased accumulation and degradation of oxidized LDL (OX-LDL) in the artery wall in vivo. 18 These studies suggest that the reason there is increased accumulation and degradation of OX-LDL is because arterial permeability to undegraded, OX-LDL is greater than arterial permeability to native LDL (N-LDL). However, the precise mechanism(s) by which modified LDL (MM-LDL) affects LDL flux in the artery wall, such as increases in permeability to LDL, remains incompletely understood.Modification of LDL (eg, oxidation), either in the circulation or the artery wall, could promote atherosclerosis by increasing LDL accumulation in the artery. Also, alteration of constituents of the artery wall, such as proteoglycans, could influence LDL binding to the artery wall. Furthermore, oxidant-mediated injury of endothelial cell membranes could compromise the endothelial layer barrier to macromolecules in arteries. 5 To counteract oxidant stress effects on LDL and/or the artery wall, a number of potential antioxidants have been examined. In particular, some estrogens (eg, 17␤-estradiol) are known to reduce LDL accumulation in the artery wall 19,20 and to be potent antioxidants. [21][22][23] In addition, estrogens may protect endothelial cells from oxidative damage. 21,22 This action would be expected to prevent increased LDL permeation into the artery wall. Furthermore, estradiol has been shown to inhibit LDL oxidation in vivo at supraphysiological 24 and physiolo...

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Section: Plasma Estradiol Measurementsmentioning

confidence: 91%

Modified LDL–Mediated Increases in Endothelial Layer Permeability Are Attenuated With 17β-Estradiol

Gardner

Banka

Roberts

et al. 1999

ATVB

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“…There have already been many reports of research in cattle (Miroud and Noakes, 1990), the horse (Britton, 1982), sheep (Krajnicakova et al, 1992), swine (Rodgers et al, 1993), the dog (Tammer et al, 1994), the cat (Shille et al, 1979), the guinea pig (Gomez and Boxaca, 1982), the monkey (Jarosz et al, 1977), and the black rhinoceroses (Kock et al, 1991), concerning the onset of estrus and the estrous cycle. External manifestations of estrus such as behavior and vaginal mucus are well known, especially in domestic animals, and changes occurred in the vaginal smears of laboratory rodents during the estrous cycle have been extensively described.…”

Section: Discussionmentioning

confidence: 99%

Exfoliative Cytology in Vaginal Vestibule of Female Asian Elephants: Relation to Circulating Progesterone Concentrations

et al. 2000

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“…Serum samples were assayed for progesterone by enzyme immunoassay (EIA) and estradiol by radioimmunoassay (RIA) at the Clinical Endocrinology Laboratory, Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA (Shille et al, 1979;Munro and Stabenfeldt, 1984 and serum hormone levels. Statistical calculations were performed using Medcalc V R statistical software, Version 9.1.0.1 1993 (Medcalc, Mariakerke, Belgium).…”

Section: Serum Hormone Analysismentioning

confidence: 99%

The Normal Genital Tract of the Female California Sea Lion (Zalophus californianus): Cyclic Changes in Histomorphology and Hormone Receptor Distribution

Colegrove

Gulland

Naydan

et al. 2009

The Anatomical Record

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Changes in reproductive tract histomorphology, and estrogen (ERa) and progesterone receptor (PR) expression throughout the breeding cycle were evaluated in free-ranging stranded female California sea lions (Zalophus californianus). Hormone receptor expression in the ovaries, uterus, cervix, and vagina was evaluated using an immunohistochemical technique with monoclonal antibodies. During a large portion of the cycle, ovaries contained both a corpora lutea (CL) and follicles in varying stages of development. In the periods of pupping and estrus during June and July, and in the spring morphologic features of the endometrium suggested estrogen influence. There were areas of squamous differentiation in the pseudostratified columnar epithelium of the cervix and vagina in some animals during estrus and in the spring. Estrogen receptor immunohistochemical scores were highest during pupping and estrus and in the spring and lowest during embryonic diapause. Cyclic changes in uterine PR expression throughout the cycle were minimal. Both ERa and PR were expressed in epithelial and stromal cells throughout the cervix and vagina, however, receptor expression was typically higher in the stroma. Stromal cell hormone receptors may play an important role in epithelial responses to circulating sex hormones. The results of this investigation add to the general knowledge of California sea lion reproduction and establish baseline information on reproductive tract hormone receptors that will aid in determining the factors involved in urogenital cancer development in sea lions.

show abstract

Follicular Function in the Domestic Cat as Determined by Estradiol-17β Concentrations in Plasma: Relation to Estrous Behavior and Cornification of Exfoliated Vaginal Epithelium

Cited by 136 publications

References 20 publications

Modified LDL–Mediated Increases in Endothelial Layer Permeability Are Attenuated With 17β-Estradiol

Modified LDL–Mediated Increases in Endothelial Layer Permeability Are Attenuated With 17β-Estradiol

Exfoliative Cytology in Vaginal Vestibule of Female Asian Elephants: Relation to Circulating Progesterone Concentrations

The Normal Genital Tract of the Female California Sea Lion (Zalophus californianus): Cyclic Changes in Histomorphology and Hormone Receptor Distribution

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