Follicular fluid PlGF/sFlt-1 ratio and soluble receptor for advanced glycation end–products correlate with ovarian sensitivity index in women undergoing A.R.T.

Nejabati, Hamid Reza; Mota, Ali; Farzadi, Laya; Ghojazadeh, Morteza; Fattahi, Amir; Hamdi, Kobra; Nouri, Mohammad

doi:10.1007/s40618-016-0550-5

Cited by 22 publications

(30 citation statements)

References 32 publications

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“…A growing body of evidence shows the involvement of various cytokines, growth factors, miRNAs, enzymes and vitamins in the female reproductive system 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 . Previous studies have reported that the FF levels of VEGF increase significantly during follicular development and reach their peak just before ovulation 33 .…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that PlGF (placental growth factor) directs VEGF to VEGFR-2 by occupying Flt-1 and thereby reinforces angiogenesis 41 . We recently reported higher FF values for the PlGF/sFlt-1 ratio in high-responder women; therefore, increased FF values of PlGF/sFlt-1 ratio could be a marker for identifying high-responders who are at risk of ovarian hyperstimulation syndrome (OHSS) 25 . On the other hand, anovulatory follicles have low Flt-1 expression 42 and probably impaired VEGF/VEGFR-2 pathway activation.…”

Section: Discussionmentioning

confidence: 99%

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Follicular Fluid Levels of Adrenomedullin 2, Vascular Endothelial Growth Factor and its Soluble Receptors Are Associated with Ovarian Response During ART Cycles

Ranjbaran

Nejabati

Ghasemnejad

et al. 2019

Geburtshilfe Frauenheilkd

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Introduction Adrenomedullin 2 (ADM2) and vascular endothelial growth factor (VEGF) affect ovarian function, especially angiogenesis and follicular development. The actions of VEGF can be antagonized by its soluble receptors, soluble Fms-like tyrosine kinase-1 (sFlt-1) and soluble VEGF receptor 2 (sVEGFR-2), as they decrease its free form. In the present study, we evaluated the relationship between follicular fluid (FF) levels of AMD2, VEGF and its soluble receptors, and ICSI outcomes. Materials and Methods ICSI cycle outcomes were evaluated and FF levels of VEGF, sFlt-1, sVEGFR-2 and ADM2 were determined using ELISA kits. Results FF levels of ADM2, VEGF, and sVEGFR-2 were significantly higher in non-responders compared to other ovarian response groups (p < 0.05). There were significant correlations between ADM2, VEGF and sVEGFR-2 levels as well as VEGF/sFlt-1 and VEGF/sVEGFR-2 ratios (r = 0.586, 0.482, 0.260, and − 0.366, respectively). Based on the ROC curve, the cutoff value for ADM2 as a non-responder predictor was 348.55 (pg/ml) with a sensitivity of 67.7% and a specificity of 94.6%. Conclusions For the first time we measured FF ADM2 levels to determine the relationship to VEGF and its soluble receptors. We suggest that ADM2 could be a potential predictive marker for non-responders. Although the exact function of ADM2 in ovarian angiogenesis is not yet understood, our study may shed light on the possible role of ADM2 in folliculogenesis and ovulation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Follicular Fluid Levels of Adrenomedullin 2, Vascular Endothelial Growth Factor and its Soluble Receptors Are Associated with Ovarian Response During ART Cycles

Ranjbaran

Nejabati

Ghasemnejad

et al. 2019

Geburtshilfe Frauenheilkd

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“…It has been reported that diabetes is accompanied by augmented levels of apoptosis of germ cells in testes and disturbance of spermatogenesis [27,28], which are associated with hormonal alterations, oxidative stress and hyperglycemia [29]. Diabetic subjects have reduced anti-oxidant capacity and/or raised oxidative damage in different tissues.…”

Section: Discussionmentioning

confidence: 99%

Anethum graveolens L‎. Alleviates Sperm ‎Damage by Limiting Oxidative Stress ‎and Insulin ‎Resistance ‎in ‎Diabetic Rats ‎

Abbasi-Oshaghi¹,

Khodadadi²,

Mirzaei³

et al. 2020

TOMCJ

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Background: It has been reported that diabetes is associated with sperm ‎damage and infertility. Objective: The purpose of this experiment was to survey the effect of Anethum graveolens L. (Dill) powder on sperm profiles, oxidative stress, insulin resistance, and histological changes in male diabetic rats. Methods: Male rats were randomly divided into 6 groups (n=7); group 1: normal rats, 2: normal rats + 100mg/kg Dill, 3: normal rats + 300mg/kg Dill, 4: diabetic rats, 5: diabetic rats + 100mg/kg Dill, and 6: diabetic rats + 300mg/kg Dill. After 2 months of treatments, the sperm profile, anti-oxidant activity, superoxide dismutase (SOD) activity, and malondialdehyde were measured. The histopathology of testis was evaluated. Hormonal changes and tumor necrosis factor-α (TNF-α) levels were measured by ELISA. Results: Total anti-oxidant and SOD activity in diabetic rats significantly decreased, while MDA concentration was significantly increased in the testis and pancreas of diabetic rats compared with control. However, the use of Dill significantly normalized these profiles. The treatment of diabetic rats with Dill changed the sperm parameters. The levels of testosterone, FSH, and LH in diabetic rats were significantly reduced, but the treatment with Dill did not alter the level of these hormones. Dill also significantly normalized testis morphological changes, insulin resistance, and inflammation. Conclusion: The use of Dill normalized oxidative stress, inflammation, and insulin resistance in diabetic rats that correlated with sperm profile and testis histological changes. The treatment of diabetic rat models with Dill did not show harmful effects on sperm profiles.

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“…This cytokine can upregulate the synthesis of extracellular matrix glycoproteins, including integrin ανβ3 32 as a marker of uterine receptivity that functions as an attachment molecule at the implantation site 12 . Inducing the LIF expression in endometrial stromal cells can be considered another positive effect of IL‐1 on implantation 33 …”

Section: Embryo‐secreted Cytokines As Markers For Embryo Selection Inmentioning

confidence: 99%

Cytokines in embryonic secretome as potential markers for embryo selection

Bahrami-Asl

Hajipour

Rezaei

et al. 2020

American J Rep Immunol

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Despite performing certain morphological assessments for selecting the best embryo for transfer, the results have not been satisfactory. Given the global tendency for performing quick and noninvasive tests for embryo selection, great efforts have been made to discover the predictive biomarkers of embryo implantation potential. In recent years, many factors have been detected in embryo culture media as a major source of embryo secretions. Previous studies have evaluated cytokines, miRNAs, extracellular vesicles, and other factors such as leukemia inhibitory factor, colony‐stimulating factor, reactive oxygen species, soluble human leukocyte antigen G, amino acids, and apolipoproteins in these media. Given the key role of cytokines in embryo implantation, these factors can be considered promising molecules for predicting the implantation success of assisted reproductive technology (ART). The present study was conducted to review embryo‐secreted molecules as potential biomarkers for embryo selection in ART.

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Follicular fluid PlGF/sFlt-1 ratio and soluble receptor for advanced glycation end–products correlate with ovarian sensitivity index in women undergoing A.R.T.

Cited by 22 publications

References 32 publications

Follicular Fluid Levels of Adrenomedullin 2, Vascular Endothelial Growth Factor and its Soluble Receptors Are Associated with Ovarian Response During ART Cycles

Follicular Fluid Levels of Adrenomedullin 2, Vascular Endothelial Growth Factor and its Soluble Receptors Are Associated with Ovarian Response During ART Cycles

Anethum graveolens L‎. Alleviates Sperm ‎Damage by Limiting Oxidative Stress ‎and Insulin ‎Resistance ‎in ‎Diabetic Rats ‎

Cytokines in embryonic secretome as potential markers for embryo selection

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