Follicular Fluid-Derived Small Extracellular Vesicles Alleviate DHEA-Induced Granulosa Cell Apoptosis by Delivering LINC00092

Whispers of the polycystic ovary syndrome theater: Directing role of long noncoding RNAs

“…LncRNAs can also bind directly to RNA-binding proteins, preventing them from interacting with their usual mRNAs or pre-mRNA targets, potentially altering mRNA splicing, stability, or translation. By binding to the RNA-binding protein LIN28B, LINC00092 not only inhibits the biogenesis of pre-miR-18a-5p but also enhances miR-18b-5p expression, thereby suppressing the PTEN signaling pathway to enhance cell viability and migration [ 43 ]. In addition, TMPO-AS1 was found to be localized in both the nucleus and cytoplasm.…”

“…LINC00092 bound to lysine demethylase 5 A (KDM5A), and KDM5A facilitated the demethylation of H3K4me3 to restrain the transcriptional activity of PTEN, thereby reducing apoptosis in ovarian cells and alleviating PCOS symptoms. [ 39 ] [ 43 ] Human and mice serum, Human GCs LINC00477 Up LINC00477 overexpression inhibited the proliferation and promoted the apoptosis of granulosa cells. Knockdown DLGPA5 (downstream of LINC0047) repressed viability and proliferation, but enhanced apoptosis and disrupted cell cycle in GCs.…”