Follicular Development

Pangas, Stephanie A.; Rajkovic, Aleksandar

doi:10.1016/b978-0-12-397175-3.00021-1

Cited by 15 publications

(5 citation statements)

References 602 publications

(550 reference statements)

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“…While in adults this pathway is an essential regulator of cell proliferation during development and oogenesis (Feng et al 2014, Irles et al 2016, Sun et al 2019, Zhang et al 2019), in sea urchin embryos is related with the development process regulation (Materna and Davidson 2012). Another gene involved in the developing gonads and granulosa cells in adult mice is the GATA-type Zinc finger protein 1 (GLP-1) (Li et al 2007, Pangas and Rajkovic 2015). This gene, not characterized in S. purpuratus , also was expressed in P. lividus females (DN31305_c0_g1_i2) and previously described in M. nudus (Sun et al 2019).…”

Section: Resultsmentioning

confidence: 99%

The male and female gonad transcriptome of the edible sea urchin, Paracentrotus lividus: identification of sex-related and lipid biosynthesis genes

Machado

Fernández-Boo

Nande

et al. 2021

Preprint

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Paracentrotus lividus is the most abundant, distributed and desirable echinoid species in Europe. Although, economically important, this species has scarce genomic resources available. Here, we produced and comprehensively characterized the male and female gonad transcriptome of P. lividus. The P. lividus transcriptome assembly has 53,865 transcripts, an N50 transcript length of 1,842 bp and an estimated gene completeness of 97.4% and 95.6% in Eukaryota and Metazoa BUSCO databases, respectively. Differential gene expression analyses yielded a total of 3371 and 3351 up regulated genes in P. lividus male and female gonad tissues, respectively. Additionally, we analysed and validated a catalogue of pivotal transcripts involved in sexual development and determination (206 transcripts) as well as in biosynthesis and storage of lipids (119 transcripts) in male and female specimens. This study provides a valuable transcriptomic resource and will contribute for the future conservation of the species as well as the exploitation in aquaculture settings.HighlightsAssembly of a reference transcriptome of Paracentrotus lividus gonads.Differential gene expression between males and female gonads of Paracentrotus lividus.Identification and validation of pivotal genes involved in biosynthesis and storage of lipids.

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Section: Resultsmentioning

confidence: 99%

The male and female gonad transcriptome of the edible sea urchin, Paracentrotus lividus: identification of sex-related and lipid biosynthesis genes

Machado

Fernández-Boo

Nande

et al. 2021

Preprint

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“…The TGFβ superfamily members, growth-differentiation factor (GDF) 9 and bone morphogenetic protein (BMP) 15 are produced by the oocyte (Dong et al , 1996; Yan et al , 2001) and genetic, pharmacological and in vitro studies have revealed multiple roles for TGFβ/SMAD signaling during follicular growth and development (Knight & Glister, 2006; Pangas & Rajkovic, 2015; Patton et al , 2021). TGFβ signalling via SMAD3 in granulosa cells acts initially in primordial follicles to maintain their quiescence (Granados-Aparici et al , 2019; Wang et al , 2014) and later, following their activation, becomes excluded from the nucleus in association with rapid granulosa cell growth and proliferation (Hardy et al , 2018).…”

Section: Introductionmentioning

confidence: 99%

SMAD4 promotes somatic-germline contact during murine oocyte growth

Granados-Aparici,

Yang,

Clarke

2023

Preprint

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Development of the oocyte requires physical contact with the surrounding granulosa cells of the follicle, which provide it with essential nutrients and regulatory signals. This contact is achieved through specialized filopodia, termed transzonal projections (TZPs), that extend from the granulosa cells to the oocyte surface. Transforming growth factor (TGFβ) family ligands produced by the oocyte increase the number of TZPs, but how they do so is unknown. Using an inducible Cre recombinase strategy together with expression of green fluorescent protein to verify Cre activity in individual granulosa cells, we examined the effect of depleting the canonical TGFβ mediator SMAD4. We observed a 20-50% decrease in the total number of TZPs in SMAD4-depleted granulosa cell-oocyte complexes, and a 50% decrease in the number of newly generated TZPs when the granulosa cells were reaggregated with granulosa cell-free wild-type oocytes. Three-dimensional image analysis revealed that TZPs of SMAD4-depleted cells were also longer than controls and more frequently oriented towards the oocyte. Strikingly, the transmembrane proteins, N-cadherin and Notch2, were reduced by 50% in these cells. SMAD4 may thus modulate a network of cell adhesion proteins that stabilize the attachment of TZPs to the oocyte, thereby amplifying signalling between the two cell types.

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“…Around age 50, there are only around 1000 follicles left after the number of follicles reduces to about 25,000 after age 37, and the rate of follicular loss increases. Thus, throughout a woman's reproductive life, only about 400 follicles will develop and ovulate, with the large bulk never doing so [ 4 ]. The ovaries can stop functioning due to various reproductive abnormalities that affect the ovaries causing discomfort, irregular menstrual periods, urinary problems, infertility, and pregnancy failure.…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Potential of Human Umbilical Cord Derived Mesenchymal Stem Cells for the Treatment of Premature Ovarian Failure

Umer¹,

Khan

Greene

et al. 2022

Stem Cell Rev and Rep

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Premature ovarian failure (POF) affects 1% of women under 40, leading to infertility. The clinical symptoms of the POF include hypoestrogenism, lack of mature follicles, hypergonadotropinism, and amenorrhea. POF can be caused due to genetic defects, autoimmune illnesses, and environmental factors. The conventional treatment of POF remains a limited success rate. Therefore, an innovative treatment strategy like the regeneration of premature ovaries by using human umbilical cord mesenchymal stem cells (hUC-MSCs) can be a choice. To summarize all the theoretical frameworks for additional research and clinical trials, this review article highlights all the results, pros, and cons of the hUC-MSCs used to treat POF. So far, the data shows promising results regarding the treatment of POF using hUC-MSCs. Several properties like relatively low immunogenicity, multipotency, multiple origins, affordability, convenience in production, high efficacy, and donor/recipient friendliness make hUC-MSCs a good choice for treating basic POF. It has been reported that hUC-MSCs impact and enhance all stages of injured tissue regeneration by concurrently stimulating numerous pathways in a paracrine manner, which are involved in the control of ovarian fibrosis, angiogenesis, immune system modulation, and apoptosis. Furthermore, some studies demonstrated that stem cell treatment could lead to hormone-level restoration, follicular activation, and functional restoration of the ovaries. Therefore, all the results in hand regarding the use of hUC-MSCs for the treatment of POF encourage researchers for further clinical trials, which will overcome the ongoing challenges and make this treatment strategy applicable to the clinic in the near future. Graphical Abstract

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Follicular Development

Cited by 15 publications

References 602 publications

The male and female gonad transcriptome of the edible sea urchin, Paracentrotus lividus: identification of sex-related and lipid biosynthesis genes

The male and female gonad transcriptome of the edible sea urchin, Paracentrotus lividus: identification of sex-related and lipid biosynthesis genes

SMAD4 promotes somatic-germline contact during murine oocyte growth

The Therapeutic Potential of Human Umbilical Cord Derived Mesenchymal Stem Cells for the Treatment of Premature Ovarian Failure

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