Follicular development during hormone replacement therapy in patients with premature ovarian insufficiency

Sato, Takuma; Kusuhara, Atsuko; Kasahara, Yuta; Haino, Takayuki; Kishi, Hiroshi; Okamoto, Aikou

doi:10.1002/rmb2.12375

Cited by 5 publications

(8 citation statements)

References 21 publications

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“…Therefore, there is a lack of safe and effective treatments to recover the damaged ovarian structure and secretion function of ovary currently. HRT lacks the long-term efficacy of improving hormone secretion rarely without adverse effects in patients with POF, and has little promotion of fertility preservation of patients [ 53 ]. In addition, lots of published studies also have demonstrated that long-term HRT increases the risk of breast cancer [ 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Adipose-derived stem cells promote the repair of chemotherapy-induced premature ovarian failure by inhibiting granulosa cells apoptosis and senescence

Meng

Guo

et al. 2023

Stem Cell Res Ther

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Background Chemotherapeutic drugs, particularly alkylating cytotoxics such as cyclophosphamide (CTX), play an important role to induce premature ovarian failure (POF). Hormone replacement therapy (HRT) is a widely used treatment to improve hormone secretion. However, the long-term HRT increases the risk of breast cancer and cardiovascular disease are attracting concerns. Therefore, there is an urgent need to develop a safe and effective treatment for POF. Method Adipose-derived stem cells (ADSCs) were isolated and identified from human adipose tissue. For POF modeling, CTX were intraperitoneal injected into CTX-acute group, CTX-chronic group, CTX-acute + ADSCs group and CTX-chronic + ADSCs group rats; For transplantation, ADSCs were transplanted into POF rats through tail-vein. The control group rats were injected with PBS. The effects of POF modeling and transplantation were determined by estrous cycle analysis, histopathological analysis, immunohistochemical staining and apoptosis-related marker. To evaluate the effects of ADSC on granulosa cells in vitro, CTX-induced senescent KGN cells were co-cultured with ADSCs, and senescent-related marker expression was investigated by immunofluorescent staining. Results In vivo studies revealed that ADSCs transplantation reduced the apoptosis of ovarian granulosa cells and secretion of follicle-stimulating hormone. The number of total follicles, primordial follicles, primary follicles, and mature follicles and secretion of anti-Müllerian hormone and estradiol (E2) were also increased by ADSCs. The estrous cycle was also improved by ADSC transplantation. Histopathological analysis showed that CTX-damaged ovarian microenvironment was improved by ADSCs. Furthermore, TUNEL staining indicated that apoptosis of granulosa cells was decreased by ADSCs. In vitro assay also demonstrated that ADSC markedly attenuated CTX-induced senescence and apoptosis of granulosa cell. Mechanistically, both in vivo and in vitro experiments proved that ADSC transplantation suppressed activation of the PI3K/Akt/mTOR axis. Conclusion Our experiment demonstrated that a single injection of high-dose CTX was a less damaging chemotherapeutic strategy than continuous injection of low-dose CTX, and tail-vein injection of ADSCs was a potential approach to promote the restoration of CTX-induced POF.

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Section: Discussionmentioning

confidence: 99%

Adipose-derived stem cells promote the repair of chemotherapy-induced premature ovarian failure by inhibiting granulosa cells apoptosis and senescence

Meng

Guo

et al. 2023

Stem Cell Res Ther

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“…Spontaniczne owulacje pojawiają się częściej w pierwszych latach trwania choroby oraz u kobiet, u których amenorrhea ma postać wtórną. Im obserwowany był dłuższy okres bezowulacyjny, tym mniejsze prawdopodobieństwo rozwoju kolejnego pęcherzyka jajnikowego [9]. Innymi wyznacznikami jajeczkowania podlegającymi ocenie są też stężenie estradiolu, inhibiny B oraz widoczne w USG pęcherzyki jajnikowe.…”

Section: Obraz Klinicznyunclassified

Premature Ovarian Insufficiency - diagnostic and therapeutic challenges

HAWRANIK

TOMASIK

WARZYSZAK

et al. 2023

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Introduction and purpose: Premature Ovarian Insufficiency (POI) is a rare but serious disease diagnosed in about 1% of women before the age of 40. It is characterized by hypoestrogenism and an increase in the level of the follicle-stimulating hormone, which is associated with menstrual disorders, pregnancy failures and a reduced quality of life. The main causes of POI include a genetic background and autoimmune abnormalities, as well as increasingly jatrogenic factors. Care for patients is focused on hormone replacement therapy and infertility treatment. The aim of this review is to discuss current treatment methods, the impact of early diagnosis and the prevention of premature ovarian insufficiency, which affects the ability to have one's own offspring. The article also describes new methods of infertility treatment that are under investigation. Materials and methods: This literature review is based on articles published in the PubMed database from 2015 to 2022 using the following phrases: premature ovarian insufficiency, premature ovarian insufficiency stem cells State of knowledge: The only way to treat infertility in women with POI is egg donation. Currently, research is being conducted to achieve early diagnosis, introduce new treatment methods and reduce the number of iatrogenic forms of POI. Conclusion: The main problem for women diagnosed with POI is the difficulty or often impossibility of having their own children. Egg donation does not allow for the transfer of the patient's genetic material, and is also not available as a treatment option in some countries. For this reason, new methods for early diagnosis, treatment, and prevention of POI are being developed.

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“…The FSH levels during menstruation with follicle (27 cycles) and non-follicle (110 cycles) development were 12.7 ± 12.5 and 13.5 ± 11.4 mIU/mL, respectively (p = 0.739), and no significant difference was observed. 58 In this protocol, estradiol is continuously administered during withdrawal bleeding. While it is a commonly used method to prevent FSH elevation, under such conditions, the decrease in FSH is not helpful in predicting subsequent follicular development.…”

Section: Lower Serum Fsh Levels Is a Necessary Condition But Does Not...mentioning

confidence: 99%

“…In addition, when applying a protocol that involves the continuous administration of estrogen medications, serum E2 levels cannot be used as an indicator. 58 In such situations, we believe that predictions made using picoAMH ELISA would be useful.…”

Section: Measurement Of Serum Amh By Picoamh Elisa and Prediction Of ...mentioning

confidence: 99%

“…However, when using E2 for prediction, it is necessary to perform blood sampling at a timing strictly without the effects of hormone replacement. In addition, when applying a protocol that involves the continuous administration of estrogen medications, serum E2 levels cannot be used as an indicator 58 . In such situations, we believe that predictions made using picoAMH ELISA would be useful.…”

Section: Follicle Growth and Its Prediction In Patients With Poimentioning

confidence: 99%

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Follicle development and its prediction in patients with primary ovarian insufficiency: Possible treatments and markers to maximize the ability to conceive with residual follicles

Osuka,

Kasahara,

Iyoshi

et al. 2023

Reprod Medicine & Biology

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BackgroundPrimary ovarian insufficiency (POI) is characterized by the development of hypergonadotropic hypogonadism before 40 years of age and leads to intractable infertility. Although in vitro fertilization and embryo transfer with donated eggs enables pregnancy, not a few patients desire pregnancy using their oocytes. However, follicular development is rare and unpredictable in patients with POI. Thus, there is a need for treatments that promote the development of residual follicles and methods to accurately predict infrequent ovulation.MethodsThis review discusses the effects of various treatments for obtaining eggs from POI patients. Furthermore, this study focused a potential marker for predicting follicular growth in patients with POI.Main FindingsDifferent treatments such as hormone‐replacement therapy, dehydroepiandrosterone supplementation, platelet‐rich plasma injection, and in vitro activation have shown varying degrees of effectiveness in retrieving oocytes from patients with POI. To predict follicle development in the cycle, elevated serum estradiol and reduced follicle‐stimulating hormone (FSH) levels are important. However, these markers are not always reliable under continuous estradiol‐replacement therapy. As a novel marker for predicting follicle growth, serum anti‐Müllerian hormone (AMH) levels, measured using the picoAMH enzyme‐linked immunosorbent assay, were found to predict follicle growth in patients and the cycle.ConclusionThis review highlights the challenges and available interventions for achieving pregnancy using a patient's oocytes in cases of POI. We believe that a combination of currently available treatments and prediction methods is the best strategy to enable patients with POI to conceive using their own eggs. Although AMH levels may predict follicle growth, further research is necessary to improve the chances of successful follicular development and conception in patients with POI.

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Follicular development during hormone replacement therapy in patients with premature ovarian insufficiency

Cited by 5 publications

References 21 publications

Adipose-derived stem cells promote the repair of chemotherapy-induced premature ovarian failure by inhibiting granulosa cells apoptosis and senescence

Adipose-derived stem cells promote the repair of chemotherapy-induced premature ovarian failure by inhibiting granulosa cells apoptosis and senescence

Premature Ovarian Insufficiency - diagnostic and therapeutic challenges

Follicle development and its prediction in patients with primary ovarian insufficiency: Possible treatments and markers to maximize the ability to conceive with residual follicles

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