Follicular development, acquisition of mature oocytes, and pregnancy after 2 weeks of leuprolide acetate administration during the midluteal phase

Vlahos, Nikolaos; Choussein, Souzana; Economopoulos, Konstantinos P.

doi:10.1016/j.fertnstert.2009.05.067

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…In several case reports, women scheduled for COH-IVF presented with multiple follicles development and high E2 levels within or after 2 weeks of GnRH agonist daily administration during the mid or late luteal phase [42][43][44]. It was reported that the retrieval of mature oocytes in luteal phase and embryo were obtained [42][43][44], as well as two pregnancies with the delivery of healthy infants [43,44].…”

Section: The Follicular Recruitment In Human Luteal Phasementioning

confidence: 99%

“…It was reported that the retrieval of mature oocytes in luteal phase and embryo were obtained [42][43][44], as well as two pregnancies with the delivery of healthy infants [43,44]. The possible explanation could be that recruitable follicles were present in luteal phase despite the presence of a functioning corpus luteum and increased levels of P. These follicles were able to respond to the "flare-up" of FSH produced by the GnRH-a and progress into mature follicles within 14 days [43].…”

Section: The Follicular Recruitment In Human Luteal Phasementioning

confidence: 99%

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Progress in understanding human ovarian folliculogenesis and its implications in assisted reproduction

Yang

Liu

et al. 2013

J Assist Reprod Genet

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Purpose To highlight recent progress in understanding the pattern of follicular wave emergence of human menstrual cycle, providing a brief overview of the new options for human ovarian stimulation and oocyte retrieval by making full use of follicular physiological waves of the patients either with normal or abnormal ovarian reserve. Methods Literature review and editorial commentary. Results There has been increasing evidence to suggest that multiple (two or three) antral follicular waves are recruited during human menstrual cycle. The treatment regimens designed based on the theory of follicular waves, to promote increased success with assisted reproduction technology (ART) and fertility preservation have been reported. These new options for human ovarian stimulation and oocyte retrieval by making full use of follicular waves of the patients either with normal or abnormal ovarian reserve lead to new thinking about the standard protocols in ART and challenge the traditional theory that a single wave of antral follicles grows only during the follicular phase of the menstrual cycle. Conclusions The understanding of human ovarian folliculogenesis may have profound implications in ART and fertility preservation. Further studies are needed to evaluate the optimal regimens in ART based on the theory of follicular waves and to identify non-invasive markers for predicting the outcome and the potential utilities of follicles obtained from anovulatory follicular waves in ART.

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Section: The Follicular Recruitment In Human Luteal Phasementioning

confidence: 99%

Section: The Follicular Recruitment In Human Luteal Phasementioning

confidence: 99%

Progress in understanding human ovarian folliculogenesis and its implications in assisted reproduction

Yang

Liu

et al. 2013

J Assist Reprod Genet

View full text Add to dashboard Cite

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Double ovarian stimulation (DuoStim) protocol for fertility preservation in female oncology patients

2017

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This article describes a revised ovarian stimulation protocol (DuoStim) for fertility preservation in female oncology patients which aims to maximise the number of gametes obtained with subsequent improvement in cumulative birth rate, without delaying cancer treatment. Ten patients diagnosed with malignancy between September 2014 and October 2015 were included. The patients were treated with the DuoStim protocol, undergoing two consecutive ovarian stimulation cycles and two oocyte retrievals. The primary outcome was the number of oocytes collected and vitrified during each oocyte retrieval and in total. The protocol was evaluated regarding medical risk and patients' feedback. During the first oocyte collection 81 oocytes (61 metaphase II) were retrieved (mean = 8.1; range = 1-13) and during the second oocyte collection 82 oocytes (67 metaphase II) were retrieved (mean= 8.2; range = 1-19). A total of 163 oocytes (128 metaphase II) were collected (mean = 16.3; range = 6-32) and cancer treatment was not delayed for any of these patients. There were no cases of ovarian hyperstimulation syndrome recorded. More patients and long-term follow-up is needed to assess the efficacy and safety of the DuoStim protocol. However, these early results are encouraging, demonstrating an increase in number of mature oocytes retrieved during ovarian stimulation for oncology patients, without delaying cancer treatment.

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Follicular development, acquisition of mature oocytes, and pregnancy after 2 weeks of leuprolide acetate administration during the midluteal phase

Cited by 2 publications

References 14 publications

Progress in understanding human ovarian folliculogenesis and its implications in assisted reproduction

Progress in understanding human ovarian folliculogenesis and its implications in assisted reproduction

Double ovarian stimulation (DuoStim) protocol for fertility preservation in female oncology patients

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