Follicular Dendritic Cells in Germinal Center Reactions

Tew, John G.; Burton, Gregory F.; Kupp, Leo I.; Szakal, Andras K.

doi:10.1007/978-1-4615-2930-9_77

Cited by 19 publications

(12 citation statements)

References 9 publications

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“…As expected, a co-localization of DT-A568 and FDCs signals was observed in case of pre-existing anti-DT immunity, indicating FDCs capture of the antibody-conjugate immune-complexes. Our observations were consistent with the described LN trafficking of immune complexes [23,30,[36][37][38]. Following the hypothesis of favored anti-carrier B response due to presentation of antibody-conjugate complexes [16], we may speculate that anti-DT antibodies can capture DT based conjugates inducing carrier-specific B cell expansion and detriment of anti-carbohydrate B cell responses.…”

Section: Discussionsupporting

confidence: 90%

“…Indeed, pre-existing antibodies are known to opsonize the antigen and form immune-complexes (ICs) that, after entering a secondary lymph node (LN), can be readily captured by CD169 + CD11c lo subcapsular sinus (SCS) macrophages or CD21/35 + follicular dendritic cells (FDCs) [17][18][19][20][21]. FDCs can display antigens on their surface over periods of days or weeks, an event thought to be important in driving the germinal center (GC) response [22,23].…”

Section: Q3mentioning

confidence: 99%

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Carrier priming effect of CRM 197 is related to an enhanced B and T cell activation in meningococcal serogroup A conjugate vaccination. Immunological comparison between CRM 197 and diphtheria toxoid

Pecetta

Tontini

Faenzi

et al. 2016

Vaccine

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Section: Discussionsupporting

confidence: 90%

Section: Q3mentioning

confidence: 99%

Carrier priming effect of CRM 197 is related to an enhanced B and T cell activation in meningococcal serogroup A conjugate vaccination. Immunological comparison between CRM 197 and diphtheria toxoid

Pecetta

Tontini

Faenzi

et al. 2016

Vaccine

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“…In line with this, we show an increased C4 staining on FDCs after OVA-Exo injection. FDCs are accessory cells of the immune system essential for affinity maturation and immunoglobulin isotype switching of B-cell clones during the germinal center reaction, [33][34][35] in which they present antigen to B and T lymphocytes. 36 FDCs are also pivotal for selection for high-affinity B-lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Antigen-loaded exosomes alone induce Th1-type memory through a B cell–dependent mechanism

Qazi

Gehrmann

Jordö

et al. 2009

Blood

202

236

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“…3 are accessory cells of the immune system essential for the germinal center reaction (1)(2)(3)(4). During germinal center reactions, FDCs present Ags to B lymphocytes and T lymphocytes (5).…”

Section: F Ollicular Dendritic Cells (Fdcs)mentioning

confidence: 99%

Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface

Denzer

Eijk

Kleijmeer

et al. 2000

The Journal of Immunology

394

324

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Follicular dendritic cells (FDCs) present in lymphoid follicles play a critical role in germinal center reactions. They trap native Ags in the form of immune complexes providing a source for continuous stimulation of specific B lymphocytes. FDCs have been reported to express MHC class II molecules, suggesting an additional role in the presentation of not only native, but also processed Ag in the form of peptide-loaded MHC class II. Adoptive bone marrow transfer experiments have shown that MHC class II molecules are only passively acquired. Up to now the origin of these MHC class II molecules was not clear. Here we show by cryoimmunogold electron microscopy that MHC class II molecules are not present at the plasma membrane of FDCs. In contrast, microvesicles attached to the FDC surface contain MHC class II and other surface proteins not expressed by FDCs themselves. The size and marker profiles of these microvesicles resemble exosomes. Exosomes, which are secreted internal vesicles from multivesicular endosomes, have been shown earlier to stimulate proliferation of specific T lymphocytes in vitro, but their target in vivo remained a matter of speculation. We demonstrate here that isolated exosomes in vitro bind specifically to FDCs and not to other cell types, suggesting that FDCs might be a physiological target for exosomes.

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Follicular Dendritic Cells in Germinal Center Reactions

Cited by 19 publications

References 9 publications

Carrier priming effect of CRM 197 is related to an enhanced B and T cell activation in meningococcal serogroup A conjugate vaccination. Immunological comparison between CRM 197 and diphtheria toxoid

Carrier priming effect of CRM 197 is related to an enhanced B and T cell activation in meningococcal serogroup A conjugate vaccination. Immunological comparison between CRM 197 and diphtheria toxoid

Antigen-loaded exosomes alone induce Th1-type memory through a B cell–dependent mechanism

Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface

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