Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells

Tew, John G.; Wu, Jiuhua; Qin, Dahui; Helm, Shirley; Burton, Gregory F.; Szakal, Andras K.

doi:10.1111/j.1600-065x.1997.tb00957.x

Cited by 230 publications

(171 citation statements)

References 69 publications

Supporting

Mentioning

164

Contrasting

Unclassified

Order By: Relevance

“…Obviously, these considerations are only relevant to the long-term consequences of priming by epitope-based immunization [31], including those utilizing helper-independent analogue CTL peptides [32]. Whether or not in our model high CTLp frequencies require persistent antigen [33] was not studied, but one cannot exclude that transgenic Ig may be stored on follicular DC as a long-term antigen depot [34].…”

Section: Discussionmentioning

confidence: 99%

Role of T cell help and endoplasmic reticulum targeting in protective CTL response against influenza virus

et al. 2003

View full text Add to dashboard Cite

We report on the induction of primary and long-term memory cytotoxic T lymphocyte (CTL) responses against the nucleoprotein of the influenza virus A/PR8/34 in mice immunized with plasmid DNA targeted to B lymphocytes in the spleen. We found that the magnitude of the CTL response and the size of the pool of memory CTL was greater when the CTL response was induced in presence of T cell help. Interestingly, immunization with a signal sequencecompetent transgene was markedly superior to immunization with a transgene lacking the endoplasmic reticulum (ER) targeting sequence, in inducing CTL. We also found a correlation between in vivo protection from lethal virus challenge and (1) the availability of T cell help and (2) ER targeting. Immunization of dendritic cell-deficient mice suggests that B lymphocytes function as antigen-presenting cells in this model of immunization. Collectively, the results suggest that somatic transgene immunization is a conceptually new approach to induce effective anti-viral CTL responses and to assess the parameters critical for long-lasting and protective CTL responses in vivo.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of T cell help and endoplasmic reticulum targeting in protective CTL response against influenza virus

et al. 2003

View full text Add to dashboard Cite

show abstract

“…As a major constituent of follicular stroma, the FDCs have been demonstrated to be instrumental in providing the necessary antigenic stimulus for the engagement of BCR on centroblasts (Tew et al, 1997). This signal is paired with a series of adhesive events aimed at strengthening the association of the two cell types.…”

Section: Discussionmentioning

confidence: 99%

Appearance and phenotype of murine follicular dendritic cells expressing VCAM‐1

et al. 2002

Self Cite

View full text Add to dashboard Cite

The architecture of lymphoid follicles is determined by a series of interactions between lymphoid and follicular stromal cells. A cardinal population in the non-lymphoid compartment is the follicular dendritic cell (FDC), whose communication with resting and activated B cells involves various adhesive interactions. The FDC phenotype variably includes the display of vascular cell adhesion molecule (VCAM-1). In this report we investigated the appearance and follicular tissue distribution of VCAM-1 in murine peripheral lymphoid tissues, and compared VCAM-1 with other FDC markers using immunohistochemistry. Correlating the appearance of VCAM-1 with other murine FDC-associated markers (CR1.2 [complement receptor 1.2 or CD35/21] and FDC-M1) revealed that the display of VCAM-1 is restricted to a subset of CR1.2-positive FDCs. We found that the expression of VCAM-1 antigen in the spleen or peripheral lymph nodes on FDCs requires antigenic stimulus, and that it coincides with germinal center formation. The VCAM-1 expression is associated with the appearance of mucosal addressin cell adhesion molecule (MAdCAM-1), with some slight differences in occurrence. The appearance of VCAM-1 and MAdCAM-1 antigens on FDCs may serve as indicators of FDC activation. Anat Rec 268: 160 -168, 2002.

show abstract

“…These results strongly suggest that PrP plays a role in the acute engagement of FDCs in humoral immune responses. The function of FDCs has been defined as the presentation of intact Ag and costimulatory signals to B cells, as a requirement for germinal center formation and hence for the maturation and maintenance of secondary immune responses (27). It can be speculated that the localization of immune-complexed Ag to the splenic follicles triggers activation of FDCs toward their tasks in the germinal center reaction.…”

Section: Discussionmentioning

confidence: 99%

Immunologically Induced, Complement-Dependent Up-Regulation of the Prion Protein in the Mouse Spleen: Follicular Dendritic Cells Versus Capsule and Trabeculae

Lötscher

Recher²,

Hunziker³

et al. 2003

The Journal of Immunology

View full text Add to dashboard Cite

The expression of the prion protein (PrP) in the follicular dendritic cell network of germinal centers in the spleen is critical for the splenic propagation of the causative agent of prion diseases. However, a physiological role of the prion protein in the periphery remains elusive. To investigate the role and function of PrP expression in the lymphoid system we treated naive mice i.v. with preformed immune complexes or vesicular stomatitis virus. Immunohistochemistry and Western blot analysis of the spleen revealed that 8 days after immunization, immune complexes and vesicular stomatitis virus had both induced a strong increase of PrP expression in the follicular dendritic cell network. Remarkably, this up-regulation did not occur in mice that lack an early factor of the complement cascade, C1q, a component which has been shown previously to facilitate early prion pathogenesis. In addition to the variable PrP level in the germinal centers, we detected steady and abundant PrP expression in the splenic capsule and trabeculae, which are structural elements that have not been associated before with PrP localization. The abundant trabeculo-capsular PrP expression was also evident in spleens of Rag-1-deficient mice, which have been shown before to be incapable of prion expansion. We conclude that trabeculocapsular PrP is not sufficient for splenic prion propagation. Furthermore, our observations may provide important clues for a physiological function of the prion protein and allow a new view on the role of complement and PrP in peripheral prion pathogenesis.

show abstract

Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells

Cited by 230 publications

References 69 publications

Role of T cell help and endoplasmic reticulum targeting in protective CTL response against influenza virus

Role of T cell help and endoplasmic reticulum targeting in protective CTL response against influenza virus

Appearance and phenotype of murine follicular dendritic cells expressing VCAM‐1

Immunologically Induced, Complement-Dependent Up-Regulation of the Prion Protein in the Mouse Spleen: Follicular Dendritic Cells Versus Capsule and Trabeculae

Contact Info

Product

Resources

About