Follicular Dendritic Cell Sarcoma of Gastrointestinal Tract: an Uncommon Lesion, Commonly Missed

Hassan, Usman; Rana, Iftikhar Ali; Mushtaq, Sajid; Azam, Muhammad; Akhter, Noreen

doi:10.1007/s12029-018-0178-0

Cited by 10 publications

(12 citation statements)

References 24 publications

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“…Variations in morphological characteristics include necrotic foci, areas of significant atypia, numerous mitoses, an extensive lymphoid infiltrate, nested and sheet-like tumor cell organization, and epithelioid appearance. 2 FDCS stain diffusely with FDC markers: CD21, CD35, and CD23. CD21 and CD35 are the most commonly used markers.…”

Section: Discussionmentioning

confidence: 99%

An incidental discovery of a gastric follicular dendritic cell sarcoma: A rare case report and a literature review

et al. 2023

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Introduction: Follicular dendritic cell sarcomas (FDCS) are rare tumours, typically seen in lymph nodes. However, in about one third of the reported cases, a FDCS presents as an extranodal mass. Involvement of the gastrointestinal tract is rare, and the stomach is even rarer with only four cases described to date. The aim of this study was to review clinical characteristics, pathologic features, emphasize on differential diagnosis and discuss therapeutic modalities and prognosis of this rare entity.Case presentation: We report on a 36-year-old female patient with no past medical history, an incidentally discovered FDCS located in the stomach with the presence of lymph node metastasis at the time of diagnosis. The diagnosis of a FDCS was made on morphological and immunohistochemical findings where tumor cells expressed CD21 and CD23. The tumor was resected by gastrectomy with extended para-aortic lymphadenectomy, with uneventful postoperative course.Conclusions: Due to its rarity, FDCS is rarely included in the differential diagnosis of gastrointestinal spindle cell tumors. Complete surgical resection is the current gold standard of treatment.

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Section: Discussionmentioning

confidence: 99%

An incidental discovery of a gastric follicular dendritic cell sarcoma: A rare case report and a literature review

et al. 2023

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“…The presenting location varies; more recent, larger studies highlight greater incidence of extranodal versus nodal disease ( 7 , 9 , 10 ). Common nodal sites include cervical, mediastinal, axillary, and intra-abdominal, while extranodal sites most often include the liver, lung, spleen, or GI tract ( 7 , 10 ).…”

Section: Discussionmentioning

confidence: 99%

Follicular Dendritic Cell Sarcoma in a Patient With Adolescent-Onset Crohn’s Disease Exposed to Multiple Immunomodulator and Biologic Therapies

et al. 2022

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Children and adolescents with inflammatory bowel disease are often treated with immunomodulators (thiopurines, methotrexate) and biologics (anti-TNF, anti-integrin) for extended periods despite concerns about long-term safety. Here, we report a case of follicular dendritic cell sarcoma, a very rare malignancy, and the first reported presentation in a patient with inflammatory bowel disease exposed to infliximab, methotrexate, and vedolizumab. We review the key clinical features and diagnostic factors of this malignancy. The pathogenesis of follicular dendritic cell sarcoma is largely unknown, however, knock out of B-cell TNF in mice has been related to follicular dendritic cell dysregulation through its impact on NF-κB pathways and CXCL13 chemokines. It is unknown whether any relationship exists between this patient's diagnosis of Crohn's disease and therapeutic exposures to this rare malignancy. We document this case in the literature to raise awareness among other clinicians who may observe a similar case.

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“… 3 The extra-nodal distribution is very wide-ranging, and the occurrence of extra-nodal FDCS has mainly been reported in the tonsils, gastrointestinal tract, soft tissues, and mediastinum. 4 The nasopharynx is an extremely rare location for FDCS, and most such cases occur sporadically. 5 These cases are quite challenging to diagnose because sarcomatoid carcinoma is much more common.…”

Section: Introductionmentioning

confidence: 99%

Follicular dendritic cell sarcoma of the nasopharynx: a case report and literature review

Xiao

Yang

2022

J Int Med Res

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Follicular dendritic cell sarcoma (FDCS) of the nasopharynx is a rare malignant tumor that has been described in only a few case reports, and its differential diagnoses include diverse clinicopathologic entities. FDCS is often initially misdiagnosed, especially when examining small biopsy specimens. We herein report a case of FDCS arising in the nasopharynx that was initially misdiagnosed as a nerve sheath tumor. A 44-year-old woman presented with persistent obstruction of the left nasal cavity and underwent an excisional biopsy. The specimen demonstrated morphologic and immunohistochemical features of FDCS. In situ hybridization for Epstein–Barr virus-encoded RNA was negative. The patient was treated with chemotherapy and radiotherapy. The sarcoma recurred near the original site more than 3 years after the initial treatment and was completely resected. At the time of this writing, the patient had remained disease-free for 1 year after resection. This case is being reported to improve the clinical recognition of FDCS.

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Follicular Dendritic Cell Sarcoma of Gastrointestinal Tract: an Uncommon Lesion, Commonly Missed

Cited by 10 publications

References 24 publications

An incidental discovery of a gastric follicular dendritic cell sarcoma: A rare case report and a literature review

An incidental discovery of a gastric follicular dendritic cell sarcoma: A rare case report and a literature review

Follicular Dendritic Cell Sarcoma in a Patient With Adolescent-Onset Crohn’s Disease Exposed to Multiple Immunomodulator and Biologic Therapies

Follicular dendritic cell sarcoma of the nasopharynx: a case report and literature review

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