Follicular dendritic cell sarcoma of the tonsil

Kara, Taylan; Serinsöz, Ebru; Arpacı, Rabia Bozdoğan; Vayısoğlu, Yusuf

doi:10.1136/bcr-2012-007440

Cited by 7 publications

(3 citation statements)

References 16 publications

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“…Radiation therapy is generally recommended for extracapsular involvement, high mitosis activity, and abundant nuclear pleomorphism with residual disease [8,10]. Absence of lymphoplasmacytic response, tumor size >6 cm, cellular atypia, or high mitotic index (≥5 per 10 HPF) are considered poor prognostic factors for thyroid FDCS [13,16,17]. Medications such as cyclophosphamide, doxorubicin, vincristine, and prednisone (i.e., lymphoma-based treatment) are among the most commonly used regimens in the treatment of this neoplasm.…”

Section: Discussionmentioning

confidence: 99%

Follicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review

et al. 2021

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Thyroid follicular dendritic cell sarcoma (FDCS) is an extremely rare malignancy that originates from follicular dendritic cells of the thyroid germinal centers. To the best of our knowledge, there are only 4 reported cases of thyroid FDCS in the English literature. Herein, we present the fifth case of FDCS of the thyroid gland. A 63-year-old woman presented with a painless midline neck mass, enlarging for the last 4 months. Physical examination revealed a 6-cm nonmobile, firm, multinodular thyroid mass with palpable cervical lymphadenopathy. Due to high suspicion for thyroid malignancy, the patient underwent total thyroidectomy with bilateral modified radical neck dissection. Histologic evaluations revealed sheets of storiform eosinophilic tumoral cells with prominent nucleoli containing multinucleated giant cells, and subsequent immunohistochemistry showed immunoreactivity for CD4, CD21, CD35, CD45 (LCA), and CD68. The patient was started on 6 cycles of doxorubicin, ifosfamide, and radiotherapy. She has had monthly thyroid ultrasonography and contrast-enhanced thoracoabdominal CT scan every 3 months for detecting potential recurrence and/or metastasis screening. Fortunately, 8 months after the operation, the patient is alive without any signs of local or distant metastasis.

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Section: Discussionmentioning

confidence: 99%

Follicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review

et al. 2021

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“…In the study by Hu et al ( 3 ), the misdiagnosis rate was 57%, higher than that in the present study. Carcinoma and FDCS cells are all ovoid cells with avesicular nuclei; however, carcinomas are positive for CK and negative for CD21, CD23 and CD35 ( 21 , 53 ). Similarly to FDCS, GISTs exhibit fascicles, storiform arrays and whorls patterns, and are negative for CK, but immune histochemical markers are positive for Dog-1, CD34 and CD117, and negative for specific markers for FDCS, which may be used to distinguish GIST from FDCS ( 5 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases

2021

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Follicular dendritic cell sarcoma (FDCS) is an extremely rare tumor, which mainly originates from FDCs in the lymph nodes. Sometimes FDCS can arise from outside the lymph nodes due to the existence of acquired lymphoid tissue, which becomes the histological basis of the tumor. The diagnosis of FDCS, particularly extranodal FDCS, presents a challenge for pathologists and hematopathologists. The present study presents two cases of extranodal FDCS based on clinical features and histomorphology. Soft tissue of the chest wall was involved in case 1 and right tonsil tissue in case 2. Case 1 underwent surgery, and was in good health post-operatively. During the 5-month post-operative follow-up period, the patient was healthy in all respects. Case 2 received surgery combined with radiotherapy, and the follow-up data reported that the patient remained alive, without signs of recurrence or metastasis during the 4-month post-operative follow-up period. Additionally, a total of 102 cases of extranodal FDCS were retrieved from the literature, which were extracted and reviewed carefully. The rates of recurrence, metastasis and mortality were 14.63 (12/82), 17.07 (14/82) and 8.29% (15/82), respectively. The overall survival rates of the 102 cases, showing 2-year total survival rates, were 70%, the same with that of 5-year total survival rates. The 2-year tumor-free total survival rates were 68%, and the 5-year equivalents were 32%. Female patients had a poorer prognosis than male patients (P<0.05). Kaplan-Meier estimation presented no statistically significant differences between disease-free survival rates or overall survival rates and age, tumor size or treatment (P>0.05).

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“…A MEDLINE and PubMed review of cases of FDCS of the head and neck from 1978 to February 2014 was conducted. Ninety‐five previous cases of head and neck FDCS were identified in the English language literature, constituting a total of 97 cases including our own (Table ) . Information on patient demographics, location, tumor size, adjuvant therapies, recurrence, and mortality was recorded for analysis.…”

Section: Methodsmentioning

confidence: 99%

Follicular dendritic cell sarcoma of the head and neck: Case report, literature review, and pooled analysis of 97 cases

et al. 2015

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Background Follicular dendritic cell sarcoma (FDCS) is a rare lymphoid neoplasm presenting in the head and neck. There are no pooled analyses of head and neck FDCS cases in the English language literature. Methods A MEDLINE and PubMed review of cases from 1978 to February 2014 was performed. Demographics, clinicopathologic data, and outcomes were summarized. Results We presented 2 patients and analyzed 97 cases. The mean age was 42.7 years (SD = 16.3 years). Outcomes were available for 76 patients. Tumors ≤4 cm had better disease-free survival (63% vs 28% at 5 years; p = .0282). Locoregional recurrence was significantly less likely with surgery and radiation compared to surgery alone (15% vs 45%; p = .019) and in patients receiving a neck dissection (10% vs 43%; p = .046). Conclusion This pooled analysis provides the largest sample size of FDCS of the head and neck to date and suggests that radiation and neck dissection may be beneficial to locoregional oncologic control.

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Follicular dendritic cell sarcoma of the tonsil

Cited by 7 publications

References 16 publications

Follicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review

Follicular Dendritic Cell Sarcoma of the Thyroid Gland in a Patient with Preexisting Hashimoto’s Thyroiditis: A Rare Case Report with a Literature Review

Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases

Follicular dendritic cell sarcoma of the head and neck: Case report, literature review, and pooled analysis of 97 cases

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