Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: A review

Fonseca, Rafaël; Yamakawa, Mitsunori; Nakamura, Sumie; Heerde, P. Van; Miettinen, Markku; Shek, Tony W. H.; Jensen, O. Myhre; Rousselet, Marie Christine; Tefferi, Ayalew

doi:10.1002/(sici)1096-8652(199810)59:2<161::aid-ajh10>3.3.co;2-i

Cited by 46 publications

(97 citation statements)

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“…Like their non-neoplastic counterpart, FDC sarcomas have shown strong uni- form positivity for CD21, CD23 and CD35 in nearly all reported cases (8,22,26,27). In these tumors, CD21 staining is detected with antibodies (e.g., DRC-1, R4/23 and Ki-M4) that preferentially recognize the FDC-associated isoform (CD21L) that is not expressed by B cells (26,28,29). Only a few cases with morphologic features of FDC sarcoma have been reported that lack both CD21 and CD35 immunoreactivity (17,30).…”

Section: Discussionmentioning

confidence: 97%

“…a Expression patterns for FDC and IDC sarcomas based on consensus of previously reported cases (8,12,17,22,23,26,27,30,44,45). b Indicates that immunohistochemical staining pattern was correlated with that seen by cDNA array transcriptional analysis of short-term stromal cell cultures of tumor and of fibroblastic stroma from non-neoplastic lymph node.…”

Section: Gene Expression Analysismentioning

confidence: 99%

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Reticulum Cell Sarcoma of Lymph Node with Mixed Dendritic and Fibroblastic Features

et al. 2001

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We report a case of clinically aggressive reticulum cell sarcoma with mixed follicular dendritic cell (FDC) and fibroblastic reticular cell (FRC) features. Histologically, the tumor was confined to lymph nodes occurring as a multifocal epithelioid and spindle cell proliferation with appreciable mitotic rate and numerous admixed non-neoplastic B-cells. IDCs have a primary function in antigen presentation in the interfollicular zones of the node and differentiate from Langerhans cells migrating from skin or from bone marrow-derived precursors (2). FRCs form a diffuse extrafollicular network that guides cell migration within the lymph node (7). Nodal sarcomas have been described that are postulated to arise from each of these different reticular cell populations. These include CD21-and CD35-positive FDC sarcoma (8) and S100-positive IDC sarcoma (9 -12). Recently, several groups have reported nodal sarcomas of possible FRC lineage (13-15). However, some of these tumors have been incompletely studied, with only limited antigen profiling and ultrastructural analysis. Thus, the range of features associated with FRC sarcoma is not yet clearly delineated. Here, we report the first morphologic, extended phenotypic and genotypic characterization of a case of primary lymph node sarcoma with mixed dendritic and fibroblastic features. METHODSHematoxylin and eosin-stained histologic sections from the original biopsy specimen obtained at an outside hospital were compared with the initial resection and tumor recurrence specimens, both done at our institution. Clinical information was obtained from the medical record.

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Section: Discussionmentioning

confidence: 97%

Section: Gene Expression Analysismentioning

confidence: 99%

Reticulum Cell Sarcoma of Lymph Node with Mixed Dendritic and Fibroblastic Features

et al. 2001

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“…IDCs are derived from the hematopoietic stem cells from bone marrow [17] and are localized in T-zones of lymphoid organs such as paracortex and deep cortex of lymph nodes, Waldayer's ring, interfollicular areas of mucosa associated lymphoid tissue and periarteriolar lymphoid sheaths in spleen [2,12]. Other dendritic cells subtypes are follicular, Langerhans and histiocytic/fibroblastic cells [18]. Tumors arising from dendritic cells are very uncommon, accounting only 1 % of hematolymphoid malignancies [2,19].…”

Section: Discussionmentioning

confidence: 99%

Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma: Case Report and Review of the Literature

Lupato

Romeo

Franchi

et al. 2015

Head and Neck Pathol

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Interdigitating dendritic cell sarcoma (IDCS) is an exceedingly rare neoplasm originating from professional antigen presenting cells normally located in the T zone of the lymph node. The purpose of this report was to describe the first case of the IDCS of the submandibular gland and perform a review of the literature of head and neck IDCS. We present a case of an 81-year-old man with a 5 months history of slowly enlarging painless mass in right submandibular region. Fine needle aspiration cytology was suggestive of squamous cell carcinoma. The patient underwent surgical resection of the right submandibular gland and neck dissection. A malignant spindle cell proliferation involving the submandibular gland and colonizing one laterocervical lymph node was found. Morphology and immunophenotype prompted a differential diagnosis of a metastatic spindle cell melanoma versus an IDCS. Transmission electron microscopy was performed and supported a diagnosis of IDCS. The diagnosis of IDCS is a challenging task and may require a large array of techniques.

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“…Limited response, short duration of clinical benefit and a 2-year overall survival rate of about 30% have been reported. 5,6,33 In 3 patients high-dose chemotherapy and autologous bone marrow transplantation have been tried without any benefit, 34-36 whereas a case report has described one complete radiological response after a chemotherapy regimen for Hodgkin lymphoma (ABVD) in metastatic disease. 37 Ultimately, the most used chemotherapy combinations contain alkylating agents and anthracyclines; in this context chemotherapy combinations indicated for sarcomas such as epirubicin and ifosfamide thus appear as a reasonable option.…”

Section: Discussionmentioning

confidence: 99%

Braf mutation in interdigitating dendritic cell sarcoma: a case report and review of the literature

Liso

Pennelli

Lodovichetti

et al. 2015

Cancer Biology & Therapy

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Interdigitating dendritic cell sarcoma is an extremely rare tumor. The diagnosis is difficult and is based on clinical, pathological and immunohistochemical evaluation. Differential diagnosis includes melanoma, mesenchymal and hematological malignancies. The mainstay of treatment is surgery for limited disease and different chemotherapy combinations have been tested for advanced disease. No evidence from prospective trials is currently available. We report the case of a 59 year-old male patient who experienced axillary lymphadenopathy with initial diagnosis of large-cell lung cancer on tumor biopsy. He underwent surgical resection with radical intent. Pathological diagnosis of interdigitating dendritic cell sarcoma was obtained on surgical samples. Nine months after radical surgery, he experienced systemic recurrence of disease and underwent chemotherapy with epirubicin and ifosfamide for 4 courses. During chemotherapy, he developed brain disease progression and underwent whole-brain radiotherapy. Systemic progression was then observed and molecular characterization was performed. B-RAF evaluation resulted positive for V600E mutation and the patient was treated with Vemurafenib according to molecular findings. He thus obtained initial clinical benefit but eventually died of brain hemorrhage. In conclusion, we report a case of B-RAF mutation detected in an interdigitating dendritic cell sarcoma patient treated with targeted therapy. B-RAF pathway could have a role in pathogenesis and evolution of this rare disease and could open new perspectives of treatment

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Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: A review

Cited by 46 publications

References 0 publications

Reticulum Cell Sarcoma of Lymph Node with Mixed Dendritic and Fibroblastic Features

Reticulum Cell Sarcoma of Lymph Node with Mixed Dendritic and Fibroblastic Features

Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma: Case Report and Review of the Literature

Braf mutation in interdigitating dendritic cell sarcoma: a case report and review of the literature

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