Follicular Cysts: A Single Sign and Different Diseases. A View from Comparative Medicine

Ortega, Hugo H.; Díaz, Pablo Uriel; Salvetti, Natalia Raquel; Hein, Gustavo Juan; Marelli, Belkis Ester; Rodríguez, Fernanda Mariel; Stassi, Antonela Florencia; Rey, Florencia

doi:10.2174/1381612822666160804100941

Cited by 21 publications

(14 citation statements)

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“…Knowledge concerning the natural polyovulation process is still scarce in the plain viscacha. Therefore, it is important to delve into the physiology of the ovary to understand this process and thus propose this species as a model that will allow to understand alterations related to the ovulation such as infertility, polycystic ovarian syndrome, in both species of medical and veterinary interest (Ortega et al, ; Rodríguez et al, ), and carry out reproductive biotechnological studies.…”

Section: Discussionmentioning

confidence: 99%

Histochemistry of the zona pellucida of the ovary of a species with natural polyovulation: Lagostomus maximus (Rodentia, Hystricomorpha, Chinchillidae)

Acuña

Hoz

Díaz

et al. 2018

Reprod Domestic Animals

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This study reports the histochemistry and the distribution of glycoconjugates (GCs) in the zona pellucida (ZP) of preantral, secondary, tertiary, polyovulatory and atretic follicles of ovaries from non-pregnant (NPr) and pregnant (Pr) females of Lagostomus maximus. GCs were studied using histochemical and lectin histochemical methods. The viscacha ZP was positive to all the histochemical techniques. In addition, it was observed that the intensity of staining of the ZP was constant in the different follicular stages between both female groups. The lectin histochemical study revealed that ZP was positive for certain lectins (WGA, RCA-I and CON-A) and that the labelling did not vary between the different follicular stages, but between the two groups of females. By using both histochemical techniques, it was established that the GCs present in the ZP label the complexity of the area. These results allow us to increase our knowledge on the biology of the viscacha's ovary, particularly contributing to the study of polyovulation.

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Section: Discussionmentioning

confidence: 99%

Histochemistry of the zona pellucida of the ovary of a species with natural polyovulation: Lagostomus maximus (Rodentia, Hystricomorpha, Chinchillidae)

Acuña

Hoz

Díaz

et al. 2018

Reprod Domestic Animals

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“…This disease generates important economic losses to the dairy industry because it increases the calving-to-conception and inter-calving intervals and because, if the condition persists, the animals should be eliminated from the herd (Peter, 2004;Cattaneo et al, 2014). The incidence of this disease in dairy cattle varies from 5 to 30% (Garverick, 1997;Silvia et al, 2002Silvia et al, , 2005Peter, 2004;Vanholder et al, 2006;Probo et al, 2011;Rizzo et al, 2011;Cattaneo et al, 2014;Ortega et al, 2016). COD is the result of several alterations in ovulatory mechanisms and follicular development (Ortega et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of this disease in dairy cattle varies from 5 to 30% (Garverick, 1997;Silvia et al, 2002Silvia et al, , 2005Peter, 2004;Vanholder et al, 2006;Probo et al, 2011;Rizzo et al, 2011;Cattaneo et al, 2014;Ortega et al, 2016). COD is the result of several alterations in ovulatory mechanisms and follicular development (Ortega et al, 2016). Despite the causes, when ovulation does not occur, the dominant follicle becomes an anovulatory cystic structure, interfering with normal ovarian function (Peter, 2004).…”

Section: Introductionmentioning

confidence: 99%

Follicular structures of cows with cystic ovarian disease present altered expression of cytokines

Stassi

Gareis

Marelli

et al. 2019

Zygote

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SummaryOvulation is considered an inflammatory, cytokine-mediated event. Cytokines, which are recognized as growth factors with immunoregulatory properties, are involved in many cellular processes at the ovarian level. In this sense, cytokines affect fertility and are involved in the development of different ovarian disorders such as bovine cystic ovarian disease (COD). Because it has been previously demonstrated that ovarian cells represent both sources and targets of cytokines, the aim of this study was to examine the expression of several cytokines, including IL-1β, IL-1RA, IL-1RI, IL-1RII, IL-4 and IL-8, in ovarian follicular structures from cows with spontaneous COD. The protein expression of these cytokines was evaluated by immunohistochemistry. Additionally, IL-1β, IL-4 and IL-8 concentrations in follicular fluid (FF) and serum were determined by enzyme-linked immunosorbent assay (ELISA). In granulosa and theca cells, IL-1RI, IL-1RII, IL-1RA and IL-4 expression levels were higher in cystic follicles than in the control dominant follicles. The serum and FF concentrations of IL-1β and IL-4 showed no differences between groups, whereas IL-8 concentration was detected only in FF of cysts from cows with COD. The FF and serum concentrations of IL-1β and IL-8 showed no significant differences, whereas IL-4 concentration was higher in FF than in serum in both the control and COD groups. These results evidenced an altered expression of cytokines in ovaries of cows with COD that could contribute to the pathogenesis of this disease.

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“…The pathogenesis of the ovarian cysts in domestic animals has been the objective of studies and researches for many years, but is still poorly understood. Some authors believe that the aetiology is multifactorial (Ortega et al, ; Peter, ). Possibly, the stress contributes with the formation of the cysts in sows (Scholten & Liptrap, ).…”

Section: Introductionmentioning

confidence: 99%

Lectin histochemical pattern on the normal and cystic ovaries of sows

Mendes

Pinto

Gimeno

et al. 2019

Reprod Domestic Animals

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The lectin histochemical pattern (LHP) was characterized and compared in normal and cystic ovaries of sows. Six biotinylated lectins (PNA, SBA, WGA, RCA‐1, DBA and UEA‐1) were used on tissue sections. In the normal ovaries, the reaction to UEA‐1 and SBA was mild to moderate in mesothelial and endothelial cells. RCA‐1 staining was mild to moderate in theca interna of growing follicles, corpora luteum and mesothelium. In addition, this lectin presented strong reaction in endothelial cells, granulosa cells of atretic follicles, zona pellucida of growing follicles and plasma. DBA showed strong intensity in mesothelial and endothelial cells. There was mild to moderate reactivity to WGA in granulosa cells, corpus luteum and theca interna of follicles in development, and moderate in zona pellucida, in granulosa cells of atretic follicles and mesothelium. PNA staining was mild to moderate in oocytes and in the adventitia and media of medullary arteries. Changes in the LHP of the cystic ovaries were noted; however, there were no differences in these findings between the follicular and luteinized cysts. UEA‐1 reactivity in the cystic ovaries was moderately reduced in the mesothelial and endothelial cells, whereas there was mild reduction in the DBA staining in the granulosa cells. Reaction to RCA‐1 and WGA in the cysts also was decreased in theca interna, zona pellucida and granulosa cells of atretic follicles. Furthermore, endothelium and theca interna in the cystic ovaries presented mild reduction of marcation to SBA, whereas there was decreased reactivity to PNA in the oocytes and adventitia and media layers of the medullary arteries. The results of the current study show that cysts modify the LHP in swine ovaries. These changes of glycoconjugates in many ovarian structures could modify diverse process and may be one of the reasons for decreased fertility in sows.

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Follicular Cysts: A Single Sign and Different Diseases. A View from Comparative Medicine

Cited by 21 publications

References 0 publications

Histochemistry of the zona pellucida of the ovary of a species with natural polyovulation: Lagostomus maximus (Rodentia, Hystricomorpha, Chinchillidae)

Histochemistry of the zona pellucida of the ovary of a species with natural polyovulation: Lagostomus maximus (Rodentia, Hystricomorpha, Chinchillidae)

Follicular structures of cows with cystic ovarian disease present altered expression of cytokines

Lectin histochemical pattern on the normal and cystic ovaries of sows

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