Follicular carcinoma in a functioning struma ovarii

Bhansali, Anil; Jain, Vanita; Rajwanshi, Arvind; Lodha, Sambhav; Dash, R. J.

doi:10.1136/pgmj.75.888.617

Cited by 23 publications

(14 citation statements)

References 6 publications

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“…8,9 Previous reports have shown that patients with struma ovarii are largely without symptoms, or are accompanied by non-specific symptoms that are similar to other ovarian neoplasms. 10 The results of this study seem to be in agreement with the above observations as demonstrated by the fact that in 14 of the 34 patients, there were no presenting symptoms, and the tumors were discovered during routine check-up ultrasound studies.…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics of struma ovarii

et al. 2008

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Objective: To evaluate the clinical characteristics of struma ovarii. Methods: Twenty-five cases of struma ovarii were reviewed retrospectively from June 1994 to April 2007. The presenting clinical, radiologic, and pathologic features of the patients were reviewed. Results: The mean age of the patients in this study was 45.3 years. The majority was of premenopausal status. Sixteen patients had clinical symptoms such as low abdominal pain, palpable abdominal mass and vaginal bleeding. Although one patient had an abnormal thyroid function test, the laboratory findings normalized after operative treatment. CA-125 levels were elevated in 6 cases. Diagnosis by preoperative imaging studies were 8 dermoid cysts, while only 3 cases were diagnosed as struma ovarii. There were 4 cases of malignant struma ovarii, and no patients with recurrent disease. Conclusion: Struma ovarii is a rare tumor. The presented clinical, laboratory and radiological findings of patients are very diverse. The diagnosis was confirmed by pathologic findings. The treatment of benign struma ovarii is surgical resection only. The cases of malignant struma ovarii may need adjuvant treatment, but recurrence is uncommon.

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Section: Discussionmentioning

confidence: 99%

“…8,16 Distant metastasis has been reported to be a very uncommon feature of struma ovarii, and even if present, has a protracted course. An extreme case where distant metastasis was discovered 26 years after initial diagnosis has been reported.…”

Section: 13mentioning

confidence: 99%

Clinical characteristics of struma ovarii

et al. 2008

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“…However, strumae with follicular, anaplastic and Hürthle cell thyroid carcinoma have also been described [7,8,21]. The left ovary appears to be more frequently involved in struma ovarii than the right and in 6% of instances strumae ovarii are bilateral [16].…”

Section: Discussionmentioning

confidence: 99%

Malignant Struma ovarii: Report of a Case and Review of the Literature

Kostoglou-Athanassiou

Lekka-Katsouli²,

Gogou³

et al. 2002

Horm Res Paediatr

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Malignant struma ovarii is a very rare disease and therefore there is neither common agreement on treatment regimens nor sufficient follow-up experience. The case of a 38-year-old woman with malignant struma ovarii is described. The patient presented with a clinically silent ovarian neoplasm discovered incidentally during investigations for metrorrhagia. The ovarian mass was resected and the tumor was found to be a teratoma. Within the teratoma a papillary thyroid carcinoma of the follicular variant was found. Subsequently, in order to make follow-up of the patient possible by thyroglobulin measurement and radioiodine whole body scintigraphy, near-total thyroidectomy was performed and the thyroid was found to be normal on histology. Whole body radioiodine scintigraphy with ¹³¹I and ablation of the thyroid remnant by the administration of 80 mCi ¹³¹I was performed. The patient recovered uneventfully and is now well.

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“…Although 5%-15% of all ovarian teratomas may contain some thyroid tissue, only 2% of these are made exclusively of struma ovarii. About 5% of all struma ovarii are malignant (1). We report the case of a malignant struma ovarii that presented with disseminated lung metastases 4 years after ablation of the ovarian tumor.…”

Section: Introductionmentioning

confidence: 95%

Malignant Struma Ovarii: An Unusual Presentation

Checrallah¹,

Medlej²,

Saade³

et al. 2001

Thyroid

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Malignant struma ovarii is a rare disease; only a few cases are well documented in the literature. Thus, the overall prognosis and modalities of treatment are still somewhat controversial. In this article, the authors report a case of malignant struma ovarii discovered 4 years after ovariectomy after metastasis to the lungs and bones. Review of the pathology of the ovarian struma did not reveal the classic criteria of malignancy, there were, however, many features considered to be atypical and thus suspicious. The patient was treated by total thyroidectomy followed by repetitive doses of 131I. However, because of difficulties in increasing the level of endogenous thyrotropin (TSH) because of functional thyroid metastases in such an advanced disease, recombinant human thyrotropin (rhTSH; Thyrogen, thyrotropin alpha, Genzyme Corporation, Cambridge, MA) was used before administration of radioiodine. With this therapeutic protocol, the patient is still clinically stable 2 years after diagnosis.

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Follicular carcinoma in a functioning struma ovarii

Cited by 23 publications

References 6 publications

Clinical characteristics of struma ovarii

Clinical characteristics of struma ovarii

Malignant Struma ovarii: Report of a Case and Review of the Literature

Malignant Struma Ovarii: An Unusual Presentation

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