Follicular blood flow is a better predictor of the outcome of in vitro fertilization–embryo transfer than follicular fluid vascular endothelial growth factor and nitric oxide concentrations

Kim, Ki Hyung; Oh, Dae Sik; Jeong, Jin-Yong; Shin, Byung Sub; Joo, Bo Sun; Lee, Kyu Sup

doi:10.1016/j.fertnstert.2004.02.120

Cited by 40 publications

(29 citation statements)

References 28 publications

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“…In contrast to these findings, Kim et al (98) could not verify the relationship between VEGF concentration in FF and age or pregnancy outcome. Also, no correlation was found between VEGF concentration in FF and the cause of infertility (98).…”

Section: Vascular Endothelial Growth Factormentioning

confidence: 77%

Review of the role of the plasminogen activator system and vascular endothelial growth factor in subfertility

Ebisch

Thomas

Wetzels

et al. 2008

Fertility and Sterility

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Section: Vascular Endothelial Growth Factormentioning

confidence: 77%

Review of the role of the plasminogen activator system and vascular endothelial growth factor in subfertility

Ebisch

Thomas

Wetzels

et al. 2008

Fertility and Sterility

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“…The level of follicular vascularity (Van Blerkom et al 1997, Chui et al 1997, Bhal et al 1999, Huey et al 1999, Kim et al 2004) and dissolved oxygen in follicular fluid (Van Blerkom et al 1997) have been related to the developmental competence of the oocyte and/or in-vitro fertilisation (IVF) outcome, but these parameters are difficult to measure. The reliable measurement of dissolved oxygen levels in follicular fluid requires attention to the avoidance of preanalytical errors (Redding et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Mathematical modelling of oxygen transport-limited follicle growth

Redding¹,

Bronlund²,

Hart³

2007

Reproduction

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Mathematical modelling was used to investigate oxygen transport in the developing ovarian follicle. In contrast to previous findings, the results show that oxygen can reach the oocyte in large preantral follicles. This is largely due to the inclusion of fluid voidage in the model and improved estimates of oxygen diffusion coefficients through the granulosa. The results also demonstrate that preantral follicles will eventually reach a size beyond which further growth will result in the follicle becoming increasingly anoxic. The predicted size range at which this occurs is consistent with the size range at which antrum formation is observed in many mammals. This suggests that the antrum formation stage of follicular growth may be pivotal to the further development and ultimate fate of the follicle, and that antrum formation itself may represent a mechanism by which the follicle can overcome oxygen limitations. This was supported through extension of the model to the antral follicle, which showed that antrum formation can provide a way in which the follicle can continue to grow and yet avoid becoming hypoxic. The results of the model were consistent with observed follicle development.

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“…The increased uterine perfusion in the 1 st wave cycles may have been related to the higher total plasma estrogen concentration on Day -1 because it has been demonstrated in previous studies [8,21] that there are relationships between uterine perfusion and plasma estrogen levels. It can be assumed that these increases in uterine blood flow and in plasma estrogen concentrations lead to an improvement in fertility because positive relationships could be observed between estrogen levels during the time of insemination and fertility in cows [4] as well as between uterine perfusion and pregnancy rate in women [32,33]. This hypothesis needs to be confirmed in future field studies.…”

Section: Discussionmentioning

confidence: 98%

Genital Blood Flow and Endometrial Gene Expression During the Preovulatory Period after Prostaglandin F2.ALPHA.-Induced Luteolysis in Different Luteal Phases in Cows

Jordan

Herzog

Ulbrich

et al. 2009

Journal of Reproduction and Development

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Abstract. The aim of this study was to examine the hypothesis that follicular and uterine perfusion as well as endometrial gene expression during the ovulatory period differs after induction of luteolysis during the 1 st follicular wave compared with the 2 nd wave or in intact cycle. Nine healthy non-lactating Holstein-Friesian cows were examined during three estrous cycles. A prostaglandin F2α analogue (PGF) was administered randomly either on Day 7 (1 st wave cycle) or Day 11 (2 nd wave cycle) after detection of ovulation (=Day 1). No hormonal treatment was used in the intact cycle with spontaneous ovulation. Transrectal Doppler sonography was conducted daily after PGF injection and in the intact cycle beginning on Day 18 of the estrous cycle until ovulation. Follicular blood flow (FBF) was determined by measuring the maximum area of colour pixels on digitalized images of the follicles. Uterine blood flow was quantified by the time-averaged maximum velocity (UTAMV) and pulsatility index (PI) in both uterine arteries. Blood flow measurements were carried out on Days -1 and 0. Endometrial biopsy specimens were taken on Day 1 and analyzed for the gene expressions of estrogen, progesterone, oxytocin and VEGF receptors and eNOS and iNOS using RT-PCR. The interval from PGF injection to ovulation was shorter (P<0. [309][310][311][312][313][314][315] 2009) here are several reports about differences in the size and contents of follicles of the first and other follicular waves in cows [1][2][3][4]. Follicular fluid of the dominant follicle of the first follicular wave shows a higher concentration of estradiol than fluid of follicles of the second wave [2]. Furthermore, thecal cells from the dominant follicle of the first wave cultured in vitro secrete more progesterone than those of the dominant follicle of the second wave. Despite lower estradiol and progesterone concentrations, dominant follicles of the second wave are larger than those of the first wave [2]. However, the size of the dominant follicle is not an indicator of its functional status [3,4]. In cycling cows, angiogenesis, as determined by colour Doppler sonography, is a good parameter for evaluation of the functional status of the follicle. Follicular perfusion is markedly higher in dominant follicles than in subdominant follicles [5], and the walls of atretic follicles lack blood flow [6]. In a recent colour Doppler sonographic study, the vascularity of the preovulatory follicle was investigated in heifers before insemination. The results supported the hypothesis of a positive relationship between the extent of blood flow of the preovulatory follicle and successful establishment of pregnancy in cattle [7].The technique of colour Doppler sonography allows not only the determination of ovarian perfusion, but also measurement of uterine blood supply [8]. Although up to now only little information has been available in cows about changes in uterine blood flow during the estrous cycle [8] and pregnancy [9,10], a relationship between uterine perfusion and fe...

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Follicular blood flow is a better predictor of the outcome of in vitro fertilization–embryo transfer than follicular fluid vascular endothelial growth factor and nitric oxide concentrations

Cited by 40 publications

References 28 publications

Review of the role of the plasminogen activator system and vascular endothelial growth factor in subfertility

Review of the role of the plasminogen activator system and vascular endothelial growth factor in subfertility

Mathematical modelling of oxygen transport-limited follicle growth

Genital Blood Flow and Endometrial Gene Expression During the Preovulatory Period after Prostaglandin F2.ALPHA.-Induced Luteolysis in Different Luteal Phases in Cows

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